{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:37:58Z","timestamp":1784893078739,"version":"3.55.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The causal associations between dietary intake and the risk and severity of Inflammatory Arthritis (IA) are currently unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we aimed to investigate the causal relationship between nine dietary categories (30 types of diet) and IA using Mendelian randomization (MR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data from 30 diets and IA in a genome-wide association study (GWAS). Single nucleotide polymorphisms (SNPs) that could influence the results of MR analyses were screened out through the Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test. SNPs were analyzed through two-sample bidirectional MR using inverse variance weighting, MR-Egger regression, and weighted median method. The multiplicity and heterogeneity of SNPs were assessed using MR-Egger intercept term tests and Cochran\u2019s <jats:italic>Q<\/jats:italic> tests. FDR correction was used to correct the <jats:italic>p<\/jats:italic>-values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IVW results showed that Beef intake [Odds ratio (OR)\u2009=\u20092.862; 95% confidence interval (CI), 1.360\u20136.021, <jats:italic>p<\/jats:italic>\u2009=\u20090.006, <jats:italic>p_fdr<\/jats:italic>\u2009&amp;lt;\u20090.05] was positively associated with rheumatoid arthritis(RA); Dried fruit intake (OR\u2009=\u20090.522; 95% CI, 0.349\u20130.781, <jats:italic>p<\/jats:italic>\u2009=\u20090.002, <jats:italic>p_fdr<\/jats:italic>\u2009&amp;lt;\u20090.05), and Iron intake (OR\u2009=\u20090.864; 95%CI, 0.777\u20130.960, <jats:italic>p<\/jats:italic>\u2009=\u20090.007, <jats:italic>p_fd<\/jats:italic>r\u2009&amp;lt;\u20090.05) were negatively associated with RA, all of which were evidence of significance. Fresh fruit intake (OR\u2009=\u20092.528. 95% CI, 1.063\u20136.011, <jats:italic>p<\/jats:italic>\u2009=\u20090.036, <jats:italic>p_fdr<\/jats:italic>\u2009&amp;gt;\u20090.05) was positively associated with psoriatic arthritis (PsA); Cheese intake (OR\u2009=\u20090.579; 95% CI, 0.367\u20130.914, <jats:italic>p<\/jats:italic>\u2009=\u20090.019, <jats:italic>p_fdr<\/jats:italic>\u2009&amp;gt;\u20090.05) was negatively associated with PsA; both were suggestive evidence. Processed meat intake (OR\u2009=\u20090.238; 95% CI, 0.100\u20130.565, <jats:italic>p<\/jats:italic>\u2009=\u20090.001, <jats:italic>p_fdr<\/jats:italic>\u2009&amp;lt;\u20090.05) was negatively associated with reactive arthritis (ReA), a protective factor, and significant evidence. All exposure data passed the heterogeneity check (Cochrane\u2019s <jats:italic>Q<\/jats:italic> test <jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05) and no directional pleiotropy was detected. Leave-one-out analyses demonstrated the robustness of the causal relationship in the positive results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study presents genetic evidence supporting a causal relationship between diet and an increased risk of IA. It also identifies a causal relationship between various dietary modalities and different types of IA. These findings have significant implications for the prevention and management of IA through dietary modifications.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1426125","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T13:05:16Z","timestamp":1721221516000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Diet affects inflammatory arthritis: a Mendelian randomization study of 30 dietary patterns causally associated with inflammatory arthritis"],"prefix":"10.3389","volume":"11","author":[{"given":"Haiyang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengda","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaorong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licheng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1136\/annrheumdis-2018-213585","article-title":"2018 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