{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:57:47Z","timestamp":1790715467408,"version":"4.1.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Many probiotics have the ability to produce extracellular polysaccharides (EPS). EPS derived from these probiotics has been confirmed to regulate the host intestinal microecological balance and alleviate the symptoms of diseases caused by gastrointestinal microecological imbalance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lactic acid bacteria (LAB) strain with good exopolysaccharide (EPS) producing ability, namely,\n                      <jats:italic>Lacticaseibacillus paracasei<\/jats:italic>\n                      ZFM54 (\n                      <jats:italic>L. paracasei<\/jats:italic>\n                      ZFM54) was screened. The fermentation conditions of\n                      <jats:italic>L. paracasei<\/jats:italic>\n                      ZFM54 for EPS production were optimized. The EPS54 was characterized by chemical component and monosaccharide composition determination, UV, FT-IR and NMR spectra analysis. Cango red, SEM, AFM and XRD analysis were conducted to characterize the structure of EPS54. The EPS54 effectively reduced the colonization of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      to AGS cells and recovered the cell morphology. EPS54 could also effectively alleviate the gastritis in the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -infected mice by down-regulating the mRNA expression levels of pro-inflammatory cytokines IL-6, IL-8, IL-1\u03b2 and TNF-\u03b1 and up-regulating the mRNA expression of inflammatory cytokine IL-10 in gastric cells. EPS54 was also found to be able to positively regulate the structure of gastric microbiota.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The EPS 54 from\n                      <jats:italic>L. paracasei<\/jats:italic>\n                      ZFM54 can alleviate gastritis in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -infected mice by modulating the gastric microbiota.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2024.1426358","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:41:36Z","timestamp":1719189696000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Exopolysaccharide from Lacticaseibacillus paracasei alleviates gastritis in Helicobacter pylori-infected mice by regulating gastric 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