{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:18:37Z","timestamp":1769548717683,"version":"3.49.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Spontaneous abortion (SA) is reported to be associated with Fat Mass And Obesity-Associated FTO genotype and dietary intake of selenium. This research assessed the potential interactions between the risk of SA, dietary selenium intake, and the FTO rs9939609 polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case-control study encompassed 192 women who experienced SA and 347 control participants. Dietary selenium intake was evaluated using a comprehensive food frequency questionnaire (FFQ) and Nutritionist IV software. The FTO gene was genotyped for rs9939609 polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The findings showed that there were no significant variations in the case and control groups\u2019 dietary selenium intake. A lower selenium intake was inversely associated with SA only among individuals with the TT genotype of the FTO gene (<jats:italic>\u03b2<\/jats:italic>\u202f=\u202f\u22120.19, <jats:italic>p<\/jats:italic>\u202f=\u202f0.04). The results remained unchanged when age, BMI, physical activity, smoking, alcohol consumption, and calorie intake were taken into account.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A link may exist between selenium consumption and SA, especially in individuals with the TT genotype in the FTO gene. These findings underline the influence of genetic factors on how dietary intake impacts SA. Further investigation is required to validate these conclusions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1428648","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T14:32:39Z","timestamp":1734705159000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The interactions of spontaneous abortion, dietary intake of selenium, and fat mass and obesity associated (FTO) genotype: a case-control study in Iran"],"prefix":"10.3389","volume":"11","author":[{"given":"Narjes","family":"Nooriani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Saeedirad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheila","family":"Shekari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheyda","family":"Nami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijeh","family":"Abbasi Mobarakeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayyeh Bararnia","family":"Adabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva","family":"Khodarahmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parsa","family":"Bahmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Doaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Ajami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Gholamalizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"ref1","first-page":"759","article-title":"Endometrial progesterone and estradiol receptors in patients with recurrent early pregnancy loss of unknown etiology--preliminary report","volume":"6","author":"Carranza-Lira","year":"2000","journal-title":"Med Sci Monit"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1016\/j.fertnstert.2008.02.002","article-title":"The value of vascular endothelial growth factor, pregnancy-associated plasma protein-a, and progesterone for early differentiation of ectopic pregnancies, normal intrauterine pregnancies, and spontaneous miscarriages","volume":"91","author":"Ugurlu","year":"2009","journal-title":"Fertil Steril"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.fertnstert.2012.06.048","article-title":"Evaluation and treatment of recurrent pregnancy loss: a committee opinion","volume":"98","year":"2012","journal-title":"Fertil Steril"},{"key":"ref4","first-page":"hoy004","article-title":"ESHRE guideline: recurrent pregnancy loss","volume-title":"Hum Reprod Open","author":"Bender Atik","year":"2018"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e111809","DOI":"10.5812\/semj.111809","article-title":"Short-term physical and psychological health consequences of induced and spontaneous abortion: a cross-sectional study","volume":"22","author":"Alipanahpour","year":"2021","journal-title":"Shiraz E-Med J"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1193995","DOI":"10.3389\/fendo.2023.1193995","article-title":"Associations between obesity, smoking behaviors, reproductive traits and spontaneous abortion: a univariable and multivariable Mendelian randomization study","volume":"14","author":"Wang","year":"2023","journal-title":"Front Endocrinol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/oby.2002.74","article-title":"Obesity increases the risk of spontaneous abortion during infertility treatment","volume":"10","author":"Wang","year":"2002","journal-title":"Obes Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.fertnstert.2007.07.1290","article-title":"Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? 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