{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:39:08Z","timestamp":1767008348507,"version":"3.41.2"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nutritional problem after surgery for Hirschprung\u2019s disease (HSCR) was not optimistic. This study aimed to analyze the risk factors of postoperative undernutrition for patients with HSCR and establish a scoring system for predicting postoperative undernutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of 341 patients with HSCR who received Laparoscopic-assisted pull-through surgery in a tertiary-level pediatric hospital was conducted with assessments of clinical data. Univariate\/multivariate Logistic regression analysis was used to identify independent factors of postoperative undernutrition, and establish a scoring system for predicting postoperative nutritional status based on the sum of adjusted odds ratios (ORs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The postoperative undernutrition of 341 patients with HSCR was 29.9%. Multivariate Logistic regression analysis showed that non-breast feeding (mixed: OR\u202f=\u202f6.116, artificial: OR\u202f=\u202f12.00), preoperative undernutrition (risk of malnutrition: OR\u202f=\u202f7.951, malnutrition: OR\u202f=\u202f8.985), non-parental caregivers (OR\u202f=\u202f3.164), long-segment HSCR (OR\u202f=\u202f12.820), postoperative complications within 30\u202fdays (grade 1\u202f~\u202f2: OR\u202f=\u202f2.924, Grade 3\u202f~\u202f4: OR\u202f=\u202f6.249), and surgery for other systemic malformation (OR\u202f=\u202f5.503) were risk factors for postoperative undernutrition (all <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05), and scoring system was developed based on these determinants. The area under the receiver operator characteristic curve of the derivation sample was 0.887 (95% confidence interval [CI]: 0.839\u20130.934) and that of the validation sample was 0.846 (95% CI: 0.772\u202f~\u202f0.920) with the optimal cut-off value of 12; calibration curves of the derivation sample showed considerable predictive performance for postoperative undernutrition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Risk factors identified affecting postoperative undernutrition should be taken seriously in patients with HSCR. We successfully developed a desirable scoring system to predict postoperative nutritional status, which might be helpful for clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1441104","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T16:17:14Z","timestamp":1733501834000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors and simple scoring system for predicting postoperative nutritional status of Hirschsprung\u2019s disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Xiaohong","family":"Die","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aohua","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/s41572-023-00465-y","article-title":"Hirschsprung 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