{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:36:45Z","timestamp":1780583805444,"version":"3.54.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Backround<\/jats:title><jats:p>Diets high in dietary acid load are thought to be associated with metabolic diseases. However, the number of studies examining the relationship between dietary acid load and metabolic diseases in Turkey is insufficient. The aim of this study was to investigate the relationship between cardiovascular disease risk factors and dietary acid load in individuals with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In this case\u2013control study, 51 participants aged 30\u201365\u2009years with type 2 diabetes and 59 participants in the control group were included. Blood pressure and biochemical findings were measured. Anthropometric measurements and body composition measurements were made. Dietary intake was assessed using a 3-day (1\u2009day on weekends, 2\u2009days on weekdays) food consumption record. Dietary acid load scores, including potential renal acid load (PRAL) and net endogenous acid production (NEAP), were calculated based on dietary intake. NEAP and PRAL scores were categorized as low and high according to the median value. Smoking status, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), trigylceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL), waist-hip ratio (WHR), waist-to- height ratio (WtHR), hemoglobin and fat mass (%) were evaluated as cardiovascular risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cut-off values of PRAL and NEAP were 3.61 and 44.78\u2009mEq\/d, respectively. After adjustment for various covariates, a significant positive association between PRAL and TG levels was observed in the diabetic group [odds ratio (OR), 5.98; 95% CI, 1.45\u201324.67; <jats:italic>p<\/jats:italic> =\u20090.013]. In contrast, a negative association was found between PRAL and SBP in the control group [odds ratio (OR), 0.21; 95% CI, 0.05\u20130.83; <jats:italic>p<\/jats:italic> =\u20090.026]. However, these associations were not observed for NEAP values in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conslusions<\/jats:title><jats:p>A higher PRAL value was consistently associated with higher TG level, but other cardiovascular risk factors were not. More longitudinal and interventional studies are needed to better establish a causal effect between dietary acid load and cardiovascular risk factors in individuals with diabetes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1445933","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T15:03:56Z","timestamp":1723647836000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the relationship between dietary acid load and cardiovascular risk factors in patients with type 2 diabetes: a case\u2013control 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Disord"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3746\/pnf.2016.21.2.104","article-title":"Association between dietary acid load and insulin resistance: Tehran lipid and glucose study","volume":"21","author":"Moghadam","year":"2016","journal-title":"Prev Nutr Food Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1017\/S0007114508901288","article-title":"Association between dietary acid base load and cardiometabolic risk factors in young japanese women","volume":"100","author":"Murakami","year":"2008","journal-title":"Br J Nutr"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e0216547","DOI":"10.1371\/journal.pone.0216547","article-title":"Higher dietary acid load potentially increases serum triglyceride and obesity prevalence in adults: an updated systematic review and meta-analysis","volume":"14","author":"Abbasalizad Farhangi","year":"2019","journal-title":"PLoS 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Food","volume":"67","author":"Lamberg-Allardt","year":"2023","journal-title":"Nutr Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.3945\/ajcn.111.022343","article-title":"Dietary acid load and risk of hypertension: the Rotterdam study","volume":"95","author":"Engberink","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.3945\/jn.115.225177","article-title":"High dietary acid load score is associated with increased risk of type 2 diabetes in japanese men: the Japan public health center-based prospective study","volume":"146","author":"Akter","year":"2016","journal-title":"J Nutr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1002\/fsn3.3197","article-title":"Diet quality and dietary acid load in relation to cardiovascular disease mortality: results from Fasa PERSIAN cohort study","volume":"11","author":"Fereidouni","year":"2023","journal-title":"Food Sci Nutr"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1136\/bmj.38678.389583.7C","article-title":"Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies","volume":"332","author":"Huxley","year":"2006","journal-title":"BMJ"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3390\/nu9060538","article-title":"Diet- induced low-grade metabolic acidosis and clinical outcomes: a review","volume":"9","author":"Carnauba","year":"2017","journal-title":"Nutrients"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"F32","DOI":"10.1152\/ajprenal.00212.2002","article-title":"Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans","volume":"284","author":"Maurer","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/j.1523-1755.2004.00386.x","article-title":"The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance","volume":"65","author":"Abate","year":"2004","journal-title":"Kidney Int"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"901","DOI":"10.2215\/CJN.07190712","article-title":"Dietary and lifestyle factors and medical conditions associated with urinary citrate excretion","volume":"8","author":"Mandel","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"E426","DOI":"10.1152\/ajpendo.1978.234.4.E426","article-title":"Insulin secretion during acid-base alterations","volume":"234","author":"Rebolledo","year":"1978","journal-title":"Am J Phys"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1684\/mrh.2009.0182","article-title":"Acid-base conditions regulate calcium and magnesium homeostasis","volume":"22","author":"Rylander","year":"2009","journal-title":"Magnes Res"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1445933\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T15:03:58Z","timestamp":1723647838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1445933\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,14]]},"references-count":32,"alternative-id":["10.3389\/fnut.2024.1445933"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1445933","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,14]]},"article-number":"1445933"}}