{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:21:38Z","timestamp":1791562898566,"version":"4.3.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Complications related to diabetic foot ulcers (DFU) due to diabetes are increasing. One of the factors influencing the management and treatment of complications related to DFU is the vitamin D serum levels of patients. Therefore, we sought to comprehensively review meta-analyses from randomized controlled trials and observational studies examining the link between serum vitamin D levels and DFU outcomes in diabetic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Scopus, and ISI Web of Science until September 2024 and extracted the required data from related articles according to Inclusion criteria. The certainty of the evidence and the quality of conduct of the published meta-analyses were rated using the ASMTAR 2 tools, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>A total of 8 meta-analyses studies that met inclusion criteria were included. Based on the obtained results, it has been noted that individuals with DFU exhibit serum vitamin D levels significantly lower, ranging from \u22127.14 (5.44, 8.83) to \u22120.93 (95% CI: 0.17, 1.68) ng\/ml, compared to those with diabetes but without DFU. Furthermore, individuals exhibiting severe vitamin D deficiency are found to be at least 1.82 times more susceptible to developing DFU. Conversely, administering varying doses of vitamin D supplementation has been shown to positively affect the size and number of ulcers in DFU patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests a potential link between lower levels of vitamin D in the blood and the risk of DFU, hinting at the benefits of vitamin D supplementation in improving outcomes associated with DFU. However, caution is warranted due to the potential bias present in the included studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2024.1454779","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T11:17:08Z","timestamp":1728472628000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["The role of vitamin D in diabetic foot ulcer; an umbrella review of meta-analyses"],"prefix":"10.3389","volume":"11","author":[{"given":"Lu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Jamali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia Sernizon","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Radkhah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parmida","family":"Jamilian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.pcd.2009.08.009","article-title":"Assessment of risk factors in diabetic foot ulceration and their impact on the outcome of the disease","volume":"3","author":"Hokkam","year":"2009","journal-title":"Prim Care Diabetes"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e3268","DOI":"10.1002\/dmrr.3268","article-title":"Definitions and criteria for diabetic foot disease","volume":"36","author":"Van Netten","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e068445","DOI":"10.1136\/bmjopen-2022-068445","article-title":"Prevalence of type 2 diabetes and pre-diabetes in Sri Lanka: a systematic review and meta-analysis","volume":"13","author":"Akhtar","year":"2023","journal-title":"BMJ Open"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jcot.2021.01.017","article-title":"The current burden of diabetic foot disease","volume":"17","author":"Edmonds","year":"2021","journal-title":"J Clin Orthop Trauma"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1323315","DOI":"10.3389\/fendo.2023.1323315","article-title":"Current knowledge of morbidities and direct costs related to diabetic foot disorders: a literature review","volume":"14","author":"Waibel","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e52813","DOI":"10.7759\/cureus.52813","article-title":"Impact of diabetic foot ulcer on the health-related quality of life of diabetic patients in Khartoum state","volume":"16","author":"Hamid","year":"2024","journal-title":"Cureus"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4239\/wjd.v6.i1.37","article-title":"Literature review on the management of diabetic foot ulcer","volume":"6","author":"Yazdanpanah","year":"2015","journal-title":"World J Diabetes"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"Cd011378","DOI":"10.1007\/s11926-008-0020-y","article-title":"Nutritional interventions for treating foot ulcers in people with diabetes","volume":"7","author":"Moore","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s11926-008-0020-y","article-title":"Calcium and vitamin D: skeletal and extraskeletal health","volume":"10","author":"Khazai","year":"2008","journal-title":"Curr Rheumatol Rep"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/nu4010052","article-title":"Focus on vitamin D, inflammation and type 2 diabetes","volume":"4","author":"Chagas","year":"2012","journal-title":"Nutrients"},{"key":"ref11","volume-title":"Diabetic foot ulcer","author":"Oliver Ti","year":"2024"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"512","DOI":"10.2174\/1573399816999201012195735","article-title":"Vitamin D supplementation in diabetic foot ulcers: a current perspective","volume":"17","author":"Kurian","year":"2021","journal-title":"Curr Diabetes Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2147\/IMCRJ.S402005","article-title":"The role of vitamin D on the wound healing process: a case series","volume":"16","author":"Siregar","year":"2023","journal-title":"Int Med Case Rep J"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41387-019-0078-9","article-title":"Vitamin D and diabetic foot ulcer: a systematic review and meta-analysis","volume":"9","author":"Dai","year":"2019","journal-title":"Nutr Diabetes"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the Prisma statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"Amstar 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"100175","DOI":"10.1016\/j.deman.2023.100175","article-title":"Role of lowered level of serum vitamin D on diabetic foot ulcer and its possible pathomechanism: a systematic review, meta-analysis, and meta-regression","volume":"13","author":"Iqhrammullah","year":"2023","journal-title":"Diab Epidemiol Manag"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.clnesp.2023.01.011","article-title":"Vitamin D as adjuvant therapy for diabetic foot ulcers: systematic review and meta-analysis approach","volume":"54","author":"Kinesya","year":"2023","journal-title":"Clin Nutr Espen"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1152854","DOI":"10.3389\/fendo.2023.1152854","article-title":"The association between micronutrient levels and diabetic foot ulcer: a systematic review with meta-analysis","volume":"14","author":"Kurian","year":"2023","journal-title":"Front Endocrinol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1111\/iwj.14177","article-title":"The relationship between vitamin D deficiency and diabetic foot ulcer: a meta-analysis","volume":"20","author":"Li","year":"2023","journal-title":"Int Wound J"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/iwj.13836","article-title":"Association between vitamin D deficiency and diabetic foot ulcer wound in diabetic subjects: a meta-analysis","volume":"20","author":"Lin","year":"2023","journal-title":"Int Wound J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/wrr.12762","article-title":"Is there an association between vitamin D and diabetic foot disease? A meta-analysis","volume":"28","author":"Yammine","year":"2020","journal-title":"Wound Repair Regen"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00418-004-0678-9","article-title":"Hyperglycemia-induced oxidative stress in diabetic complications","volume":"122","author":"King","year":"2004","journal-title":"Histochem Cell Biol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"111585","DOI":"10.1016\/j.diabres.2024.111585","article-title":"Vitamin D deficiency increases the risk of diabetic peripheral neuropathy in elderly type 2 diabetes mellitus patients by predominantly increasing large-fiber lesions","volume":"209","author":"Fei","year":"2024","journal-title":"Diabetes Res Clin Pract"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1222243","DOI":"10.3389\/fcvm.2023.1222243","article-title":"Plasmacytoid dendritic cells contribute to vascular endothelial dysfunction in type 2 diabetes","volume":"10","author":"Alluri","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e10405","DOI":"10.1002\/jbm4.10405","article-title":"Vitamin D and immune regulation: antibacterial, antiviral","volume":"5","author":"Bishop","year":"2021","journal-title":"Anti-Inflammatory Jbmr Plus"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"8127","DOI":"10.3390\/nu7095383","article-title":"Regulation of dendritic cell function by vitamin D","volume":"7","author":"Barragan","year":"2015","journal-title":"Nutrients"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"15347346231205641","DOI":"10.1177\/15347346231205641","article-title":"Relationship of serum vitamin D levels with diabetic foot in patients with type 2 diabetes mellitus: a cross-sectional study","author":"Atoum","year":"2023","journal-title":"Int J Low Extrem Wounds"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1017\/S0007114514003018","article-title":"Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection","volume":"112","author":"Tiwari","year":"2014","journal-title":"Br J Nutr"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41574-021-00593-z","article-title":"The health effects of vitamin D supplementation: evidence from human studies","volume":"18","author":"Bouillon","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s13300-023-01510-5","article-title":"The international working group on the diabetic foot: stories and numbers behind three decades of evidence-based guidelines for the Management of Diabetes-Related Foot Disease","volume":"15","author":"Van Netten","year":"2024","journal-title":"Diabetes Ther"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1454779\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T11:17:11Z","timestamp":1728472631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1454779\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":31,"alternative-id":["10.3389\/fnut.2024.1454779"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1454779","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"article-number":"1454779"}}