{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:46:03Z","timestamp":1792673163833,"version":"4.5.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Magnesium plays an essential role in glucose utilization and insulin signaling. Recent advances have revealed a greater prevalence of hypomagnesemia in general, and low intracellular magnesium levels in individuals with diabetes contribute to \u03b2-cell dysfunction and insulin resistance. This article describes the documented effects of magnesium on various aspects of \u03b2-cells and glucose homeostasis. Studies have demonstrated that magnesium deficiency is associated with reduced pancreatic \u03b2-cell activity and increased insulin resistance in patients with type 2 diabetes. Additionally, magnesium is involved in many cellular events, including energy homeostasis, protein synthesis, and DNA stability. Furthermore, magnesium is critical for proper glucose utilization and insulin signaling, and magnesium deficiency can lead to the dysregulation of ATP-sensitive potassium (KATP) channels in pancreatic \u03b2-cells, impairing insulin secretion. Therefore, maintaining adequate magnesium levels is crucial for maintaining overall health and preventing of metabolic disorders such as type 2 diabetes.<\/jats:p>","DOI":"10.3389\/fnut.2024.1458700","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T21:32:44Z","timestamp":1727299964000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["The role of magnesium in pancreatic beta-cell function and homeostasis"],"prefix":"10.3389","volume":"11","author":[{"given":"Nuraly S.","family":"Akimbekov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seval Ozkan","family":"Coban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeddine","family":"Atfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Razzaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.3390\/nu10121863","article-title":"Magnesium: are we consuming enough?","volume":"10","author":"Razzaque","year":"2018","journal-title":"Nutrients"},{"key":"B2","doi-asserted-by":"publisher","first-page":"105400","DOI":"10.1016\/j.jsbmb.2019.105400","article-title":"Anabolic effects of vitamin D and magnesium in aging bone","volume":"193","author":"Erem","year":"2019","journal-title":"J Steroid Biochem Mol Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3390\/ijms20010128","article-title":"Etiology of metabolic syndrome and dietary intervention","volume":"20","author":"Xu","year":"2018","journal-title":"Int J Mol Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3390\/nu13020463","article-title":"Magnesium in aging, health and diseases","volume":"13","author":"Barbagallo","year":"2021","journal-title":"Nutrients"},{"key":"B5","first-page":"126","article-title":"Intracellular magnesium and insulin resistance","volume":"17","author":"Takaya","year":"2004","journal-title":"Magnes Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00012.2014","article-title":"Magnesium in man: implications for health and disease","volume":"95","author":"de Baaij","year":"2015","journal-title":"Physiol Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.3390\/ijms20061351","article-title":"Effects of magnesium deficiency on mechanisms of insulin resistance in type 2 diabetes: focusing on the processes of insulin secretion and signaling","volume":"20","author":"Kostov","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.7556\/jaoa.2018.037","article-title":"Role of magnesium in vitamin D activation and function","volume":"118","author":"Uwitonze","year":"2018","journal-title":"J Am Osteopath Assoc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"105636","DOI":"10.1016\/j.jsbmb.2020.105636","article-title":"Oral manifestations of magnesium and vitamin D inadequacy","volume":"200","author":"Uwitonze","year":"2020","journal-title":"J Steroid Biochem Mol Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1684\/mrh.2021.0486","article-title":"Serum magnesium: time for a standardized and evidence-based reference range","volume":"34","author":"Micke","year":"2021","journal-title":"Magnes Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"8199","DOI":"10.3390\/nu7095388","article-title":"Magnesium in prevention and therapy","volume":"7","author":"Gr\u00f6ber","year":"2015","journal-title":"Nutrients."},{"key":"B12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1159\/000477730","article-title":"Genetics of magnesium disorders","volume":"3","author":"Li","year":"2017","journal-title":"Kidney Dis (Basel)."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e74355","DOI":"10.1371\/journal.pone.0074355","article-title":"The relationship between hypomagnesemia, metformin therapy and cardiovascular disease complicating type 2 diabetes: the Fremantle Diabetes Study","volume":"8","author":"Peters","year":"2013","journal-title":"PLoS ONE."},{"key":"B14","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1159\/000450863","article-title":"Magnesium and kidney health - 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