{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:47:41Z","timestamp":1790952461419,"version":"4.1.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Insufficient dietary fiber intake has become a global public health issue, affecting the development and management of various diseases, including intestinal diseases and obesity. This study showed that dietary fiber deficiency enhanced the susceptibility of mice to colitis, which could be attributed to the disruption of the gut barrier integrity, activation of the NF-\u03baB pathway, and oxidative stress. <jats:italic>Undaria pinnatifida<\/jats:italic> fucoidan (UPF) alleviated colitis symptoms in mice that fed with a fiber deficient diet (FD), characterized by increased weight gain and reduced disease activity index, liver and spleen indexes, and histological score. The protective effect of UPF against FD-exacerbated colitis can be attributed to the alleviation of oxidative stress, the preservation of the gut barrier integrity, and inhibition of the MAPK\/NF-\u03baB pathway. UPF ameliorated the gut microbiota composition, leading to increased microbiota richness, as well as increased levels of <jats:italic>Muribaculaceae<\/jats:italic>, <jats:italic>Lactobacillaceae<\/jats:italic>, and <jats:italic>Bifidobacterium<\/jats:italic> and reduced levels of <jats:italic>Proteobacteria<\/jats:italic>, <jats:italic>Bacteroidetes<\/jats:italic>, and <jats:italic>Bacteroides<\/jats:italic>. Metabolomics analysis revealed that UPF improved the profile of microbiota metabolites, with increased levels of carnitine and taurine and decreased levels of tyrosine and deoxycholic acid. This study suggests that UPF has the potential to be developed as a novel prebiotic agent to enhance human health.<\/jats:p>","DOI":"10.3389\/fnut.2024.1462584","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T05:21:40Z","timestamp":1737696100000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Fucoidan alleviated colitis aggravated by fiber deficiency through protecting the gut barrier, suppressing the MAPK\/NF-\u03baB pathway, and modulating gut microbiota and metabolites"],"prefix":"10.3389","volume":"11","author":[{"given":"Weiyun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangru","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqing","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"14817","DOI":"10.1021\/acs.jafc.2c02066","article-title":"Effect of Lactobacillus with feruloyl esterase-producing ability on dextran sodium sulfate-induced ulcerative colitis in mice","volume":"70","author":"Shen","year":"2022","journal-title":"J Agric Food Chem"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"8201672","DOI":"10.1155\/2017\/8201672f","article-title":"New frontiers in genetics, gut microbiota, and immunity: a rosetta stone for the pathogenesis of inflammatory bowel disease","volume":"2017","author":"Zhou","year":"2017","journal-title":"Biomed Res Int"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/ajg.2011.44","article-title":"Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature","volume":"106","author":"Hou","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.3390\/ijms18071372","article-title":"Effects of non-starch polysaccharides on inflammatory bowel disease","volume":"18","author":"Nie","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bpg.2016.02.005","article-title":"Probiotics and prebiotics in ulcerative colitis","volume":"30","author":"Derikx","year":"2016","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"14864","DOI":"10.1021\/acs.jafc.2c06417","article-title":"Fucoidan ameliorated dextran sulfate sodium-induced ulcerative colitis by modulating gut microbiota and bile acid metabolism","volume":"70","author":"Liu","year":"2022","journal-title":"J Agric Food Chem"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"8976","DOI":"10.1039\/D1FO01446C","article-title":"Oat beta-glucan alleviates DSS-induced colitis via regulating gut microbiota metabolism in mice","volume":"12","author":"Bai","year":"2021","journal-title":"Food Funct"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","article-title":"Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine","volume":"4","author":"Ivanov","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1152\/ajplegacy.1959.197.6.1345","article-title":"Development of cecal distention in germ-free baby rats","volume":"197","author":"Wostmann","year":"1959","journal-title":"Am J Phys"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol Rev"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"270","DOI":"10.17305\/bjbms.2020.5016","article-title":"Dysbiosis of gut microbiota in inflammatory bowel disease: current therapies and potential for microbiota-modulating therapeutic approaches","volume":"21","author":"Alshehri","year":"2021","journal-title":"Bosn J Basic Med Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/j.ijbiomac.2020.11.116","article-title":"Sulfated polysaccharides from Undaria Pinnatifida improved high fat diet-induced metabolic syndrome, gut microbiota dysbiosis and inflammation in BALB\/c mice","volume":"167","author":"Jiang","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"12295","DOI":"10.1021\/acs.jafc.0c04773","article-title":"Anti-inflammatory and intestinal microbiota modulation properties of Jinxiang garlic (Allium sativum L.) polysaccharides toward dextran sodium sulfate-induced colitis","volume":"68","author":"Shao","year":"2020","journal-title":"J Agric Food Chem"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"8703","DOI":"10.1039\/D2FO01283A","article-title":"Impact of Lycium barbarum arabinogalactan on the fecal metabolome in a DSS-induced chronic colitis mouse model","volume":"13","author":"Cao","year":"2022","journal-title":"Food Funct"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"15.25.1","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr Protoc Immunol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.7812\/TPP\/18-107","article-title":"Westernized diet is the most ubiquitous environmental factor in inflammatory bowel disease","volume":"23","author":"Chiba","year":"2019","journal-title":"Perm J"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"619366","DOI":"10.3389\/fimmu.2021.619366","article-title":"Deficiency of dietary fiber modulates gut microbiota composition, neutrophil recruitment and worsens experimental colitis","volume":"12","author":"Shen","year":"2021","journal-title":"Front Immunol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1053\/jada.2003.50005","article-title":"The effect of fiber-rich carbohydrates on features of syndrome X","volume":"103","author":"Davy","year":"2003","journal-title":"J Am Diet Assoc"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/j.1749-6632.2009.04062.x","article-title":"Epithelial tight junctions in intestinal inflammation","volume":"1165","author":"Schulzke","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.12703\/P6-97","article-title":"MyD88: a central player in innate immune signaling","volume":"6","author":"Deguine","year":"2014","journal-title":"F1000Prime Rep"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nri1703","article-title":"NF-kappaB: linking inflammation and immunity to cancer development and progression","volume":"5","author":"Karin","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s40168-021-01172-0","article-title":"A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites","volume":"9","author":"Shi","year":"2021","journal-title":"Microbiome"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1111\/j.1440-1746.2007.04890.x","article-title":"Oxidative stress and metabolism in animal model of colitis induced by dextran sulfate sodium","volume":"22","author":"Damiani","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1080\/jmf.16.6.367.372","article-title":"Oxidative stress in diabetic pregnancy: SOD, CAT and GSH-Px activity and lipid peroxidation products","volume":"16","author":"Djordjevic","year":"2004","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1161\/ATVBAHA.119.312725","article-title":"Inhibition of MPO (myeloperoxidase) attenuates endothelial dysfunction in mouse models of vascular inflammation and atherosclerosis","volume":"39","author":"Cheng","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.lfs.2003.10.042","article-title":"iNOS-mediated nitric oxide production and its regulation","volume":"75","author":"Aktan","year":"2004","journal-title":"Life Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.3390\/pharmaceutics14112383","article-title":"Oral Macrocystis pyrifera fucoidan administration exhibits anti-inflammatory and antioxidant properties and improves DSS-induced colitis in C57BL\/6J mice","volume":"14","author":"Ahmad","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ijbiomac.2019.03.230","article-title":"Polysaccharide from Scutellaria baicalensis Georgi ameliorates colitis via suppressing NF-\u03baB signaling and NLRP3 inflammasome activation","volume":"132","author":"Cui","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.nutres.2020.01.006","article-title":"Grape peel powder attenuates the inflammatory and oxidative response of experimental colitis in rats by modulating the NF-\u03baB pathway and activity of antioxidant enzymes","volume":"76","author":"Maurer","year":"2020","journal-title":"Nutr Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.26355\/eurrev_202003_20533","article-title":"MiR-195 alleviates ulcerative colitis in rats via MAPK signaling pathway","volume":"24","author":"Bai","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"115211","DOI":"10.1016\/j.jep.2022.115211","article-title":"Preventive effect of atractylodis rhizoma extract on DSS-induced acute ulcerative colitis through the regulation of the MAPK\/NF-\u03baB signals in vivo and in vitro","volume":"292","author":"Lin","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e2200047","DOI":"10.1002\/mnfr.202200047","article-title":"Mesona chinensis benth polysaccharides alleviate DSS-induced ulcerative colitis via inhibiting of TLR4\/MAPK\/NF-kappaB signaling pathways and modulating intestinal microbiota","volume":"66","author":"Lu","year":"2022","journal-title":"Mol Nutr Food Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1080\/17474124.2017.1343143","article-title":"The intestinal barrier: a fundamental role in health and disease","volume":"11","author":"Vancamelbeke","year":"2017","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e196","DOI":"10.1038\/ctg.2016.54","article-title":"Human intestinal barrier function in health and disease","volume":"7","author":"Konig","year":"2016","journal-title":"Clin Transl Gastroenterol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/1751-2980.12849","article-title":"Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment","volume":"21","author":"Guo","year":"2020","journal-title":"J Digest Dis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/fft2.140","article-title":"Protective effect of feruloylated oligosaccharides on dextran sulfate sodium-induced ulcerative colitis in rats","volume":"3","author":"Gong","year":"2022","journal-title":"Food Front"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1053\/j.gastro.2018.12.001","article-title":"Specific bacteria and metabolites associated with response to fecal microbiota transplantation in patients with ulcerative colitis","volume":"156","author":"Paramsothy","year":"2019","journal-title":"Gastroenterology"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.3390\/microorganisms8111715","article-title":"The influence of probiotics on the Firmicutes\/Bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease","volume":"8","author":"Stojanov","year":"2020","journal-title":"Microorganisms"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1186\/gb-2012-13-9-r79","article-title":"Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment","volume":"13","author":"Morgan","year":"2012","journal-title":"Genome Biol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrgastro.2012.14","article-title":"IBD-what role do Proteobacteria play?","volume":"9","author":"Mukhopadhya","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"921075","DOI":"10.3389\/fcimb.2022.921075","article-title":"Lycium barbarum glycopeptide prevents the development and progression of acute colitis by regulating the composition and diversity of the gut microbiota in mice","volume":"12","author":"Huang","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1039\/D0FO01724H","article-title":"Alleviation of DSS-induced colitis via Lactobacillus acidophilus treatment in mice","volume":"12","author":"Kim","year":"2021","journal-title":"Food Funct"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"108353","DOI":"10.1016\/j.jnutbio.2020.108353","article-title":"Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism","volume":"79","author":"Din","year":"2020","journal-title":"J Nutr Biochem"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.ijbiomac.2020.03.053","article-title":"Anti-inflammatory properties and gut microbiota modulation of an alkali-soluble polysaccharide from purple sweet potato in DSS-induced colitis mice","volume":"153","author":"Sun","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1128\/AEM.69.4.1920-1927.2003","article-title":"Nondigestible oligosaccharides enhance bacterial colonization resistance against Clostridium difficile in vitro","volume":"69","author":"Hopkins","year":"2003","journal-title":"Appl Environ Microbiol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"10784","DOI":"10.3390\/ijms231810784","article-title":"Research progress on the protective effect of brown algae-derived polysaccharides on metabolic diseases and intestinal barrier injury","volume":"23","author":"Yang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"8448","DOI":"10.1021\/acs.jafc.1c02774","article-title":"Fuzhuan brick tea polysaccharide improved ulcerative colitis in association with gut microbiota-derived tryptophan metabolism","volume":"69","author":"Yang","year":"2021","journal-title":"J Agric Food Chem"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10157-014-1061-3","article-title":"Inflammation and L-carnitine therapy in hemodialysis patients: a review","volume":"19","author":"Khalatbari-Soltani","year":"2015","journal-title":"Clin Exp Nephrol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3390\/molecules25010182","article-title":"Carnitine in human muscle bioenergetics: can carnitine supplementation improve physical exercise?","volume":"25","author":"Gnoni","year":"2020","journal-title":"Molecules"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1021\/acs.jafc.0c07095","article-title":"Preventive and therapeutic spermidine treatment attenuates acute colitis in mice","volume":"69","author":"Ma","year":"2021","journal-title":"J Agric Food Chem"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3389\/fimmu.2016.00536","article-title":"Deoxycholic acid triggers NLRP3 inflammasome activation and aggravates DSS-induced colitis in mice","volume":"7","author":"Zhao","year":"2016","journal-title":"Front Immunol"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1462584\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T05:21:48Z","timestamp":1737696108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1462584\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":53,"alternative-id":["10.3389\/fnut.2024.1462584"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1462584","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"article-number":"1462584"}}