{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:07:42Z","timestamp":1757542062084,"version":"3.41.2"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Scurvy, a rare disease resulting from vitamin C deficiency, can occur in individuals with restrictive eating disorders like anorexia nervosa (AN), leading to severe health complications. This review explores the complex relationship between scurvy and AN, highlighting the overlapping symptoms and challenges in diagnosis and treatment. Vitamin C is essential for collagen synthesis, immune function, and neurotransmitter production, and its deficiency manifests as fatigue, gingival bleeding, joint pain, and perifollicular hemorrhages. AN exacerbates these symptoms through extreme food restriction, causing severe nutritional deficiencies. Analyzing nine case reports, this review reveals that patients with co-occurring AN and scurvy often present with gastrointestinal, psychiatric, and dermatological symptoms. Treatment with vitamin C supplementation typically results in rapid symptom improvement. However, the malnutrition inherent in AN complicates the clinical picture, making timely diagnosis and intervention crucial. This review underscores the importance of a comprehensive, multidisciplinary approach to managing these conditions, emphasizing the need for early recognition and treatment to prevent severe complications. Future research should include a more diverse patient population to enhance understanding of the interplay between AN and scurvy, aiming to improve patient outcomes through tailored treatment strategies.<\/jats:p>","DOI":"10.3389\/fnut.2024.1466388","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:48:23Z","timestamp":1725338903000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A comprehensive review on the co-occurrence of scurvy and anorexia nervosa"],"prefix":"10.3389","volume":"11","author":[{"given":"Sunny","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/ncp.10914","article-title":"History of scurvy and use of vitamin C in critical illness: a narrative review","volume":"38","author":"Dresen","year":"2023","journal-title":"Nutr Clin Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3390\/nu14030684","article-title":"A narrative review on pediatric scurvy: the last twenty years","volume":"14","author":"Trapani","year":"2022","journal-title":"Nutrients"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1146\/annurev.nu.14.070194.002103","article-title":"Pharmacology of vitamin C","volume":"14","author":"Sauberlich","year":"1994","journal-title":"Annu Rev Nutr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/BF02207657","article-title":"The importance of vitamin C for hydroxylation of vitamin D3 to 1, 25 (OH) 2D3 in man","volume":"10","author":"Cantatore","year":"1991","journal-title":"Clin Rheumatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1017\/S0954422418000124","article-title":"A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D","volume":"31","author":"Belsky","year":"2018","journal-title":"Nutr Res Rev"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/antiox7030041","article-title":"Influence of vitamin C on lymphocytes: an overview","volume":"7","author":"Van Gorkom","year":"2018","journal-title":"Antioxidants"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12887-019-1437-3","article-title":"Is vitamin C enough? 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