{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:21Z","timestamp":1787027001304,"version":"build-2736575974"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Female infertility is a multifactorial condition influenced by lifestyle and dietary factors. Understanding the relationship between nutritional status, dietary habits, and infertility could provide insights for targeted interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case-control study was conducted in health centers and hospitals in Alicante, Spain. The study included 60 infertile and 30 fertile women aged 18\u201340, selected through consecutive sampling. Data on body composition and dietary intake were collected and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Infertile women exhibited significantly lower muscle mass (\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.005) and larger hip circumference (\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.034) compared to fertile women. Additionally, a significant association was found between high red meat consumption and an increased risk of female infertility (\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These results suggest that body composition and dietary habits, particularly muscle mass and red meat intake, play a key role in female fertility. Interventions aimed at improving muscle mass, reducing localized body fat, and limiting red meat consumption may enhance fertility outcomes. Further longitudinal research is needed to confirm these findings across diverse populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2024.1476784","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:56:24Z","timestamp":1728435384000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations of nutritional status and dietary habits with the development of female infertility. A case\u2013control study"],"prefix":"10.3389","volume":"11","author":[{"given":"Laura","family":"Mart\u00edn-Manchado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Manuel","family":"Moya-Yeste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"S\u00e1nchez-Sansegundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Hurtado-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina Andrea","family":"Gil-Miralles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Tuells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Zaragoza-Mart\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"6413","DOI":"10.1002\/fsn3.3584","article-title":"Glycemic index, glycemic load, dietary inflammatory index, and risk of infertility in women","volume":"11","author":"Aghaei","year":"2023","journal-title":"Food Sci Nutr"},{"key":"ref2","year":"2023"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3389\/fendo.2019.00346","article-title":"Nutrition and female fertility: an interdependent correlation","volume":"10","author":"Silvestris","year":"2019","journal-title":"Front Endocrinol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12958-018-0336-z","article-title":"Obesity as disruptor of the female fertility","volume":"16","author":"Silvestris","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/nu8020087","article-title":"The deep correlation between energy metabolism and reproduction: a view on the effects of nutrition for women fertility","volume":"8","author":"Fontana","year":"2016","journal-title":"Nutrients"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1093\/ajcn\/88.4.886","article-title":"Lower fertility associated with obesity and underweight: the US National Longitudinal Survey of youth","volume":"88","author":"Jokela","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3390\/biology13020131","article-title":"Dietary patterns and fertility","volume":"13","author":"Cristodoro","year":"2024","journal-title":"Biology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"121069","DOI":"10.1016\/j.lfs.2022.121069","article-title":"Polycystic ovary syndrome (PCOS) increases the risk of subsequent gestational diabetes mellitus (GDM): a novel therapeutic perspective","volume":"310","author":"Choudhury","year":"2022","journal-title":"Life Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"112183","DOI":"10.1016\/j.biopha.2021.112183","article-title":"Gestational diabetes mellitus \u2013 a metabolic and reproductive disorder","volume":"143","author":"Choudhury","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref10","first-page":"1005","article-title":"Does dietary fat intake influence oocyte competence and embryo quality by inducing oxidative stress in follicular fluid?","volume":"11","author":"Kazemi","year":"2013","journal-title":"Iran J Reprod Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"8890","DOI":"10.3390\/ijms23168890","article-title":"A systematic review of the effects of high-fat diet exposure on oocyte and follicular quality: a molecular point of view","volume":"23","author":"Gonnella","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/sj.ejcn.1602904","article-title":"A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility","volume":"63","author":"Chavarro","year":"2009","journal-title":"Eur J Clin Nutr"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"210.e1","DOI":"10.1016\/j.ajog.2007.06.057","article-title":"Protein intake and ovulatory infertility","volume":"198","author":"Chavarro","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.fertnstert.2011.08.034","article-title":"Dietary patterns and difficulty conceiving: a nested case-control study","volume":"96","author":"Toledo","year":"2011","journal-title":"Fertil Steril"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1097\/01.AOG.0000287293.25465.e1","article-title":"Diet and lifestyle in the prevention of ovulatory disorder infertility","volume":"110","author":"Chavarro","year":"2007","journal-title":"Obstet Gynecol"},{"key":"ref16","year":"2024"},{"key":"ref17","volume-title":"Nutrici\u00f3n cl\u00ednica del adulto","author":"Gallar","year":"2019"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"863","DOI":"10.20960\/nh.1085","article-title":"Metabolic syndrome and visceral fat in women with cardiovascular risk factor","volume":"34","author":"Soto-Rodr\u00edguez","year":"2017","journal-title":"Nutr Hosp"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1038\/sj.ejcn.1602004","article-title":"Development of a short dietary intake questionnaire for the quantitative estimation of adherence to a cardioprotective Mediterranean diet","volume":"58","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0002-9378(94)90465-0","article-title":"Adolescent body mass index and infertility caused by ovulatory disorder","volume":"171","author":"Rich-Edwards","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/humrep\/dem371","article-title":"Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women","volume":"23","author":"Van der Steeg","year":"2008","journal-title":"Hum Reprod"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e0210770","DOI":"10.1371\/journal.pone.0210770","article-title":"Sedentary behavior, physical inactivity and body composition in relation to idiopathic infertility among men and women","volume":"14","author":"Foucaut","year":"2019","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1210\/edrv.18.6.0318","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1152\/physrev.90100.2007","article-title":"Muscle as an endocrine organ: focus on muscle-derived interleukin-6","volume":"88","author":"Pedersen","year":"2008","journal-title":"Physiol Rev"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Endocr Rev"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1007\/s43032-023-01280-2","article-title":"Body fat distribution and female infertility: a cross-sectional analysis among US women","volume":"30","author":"Wang","year":"2023","journal-title":"Reprod Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e0295360","DOI":"10.1371\/journal.pone.0295360","article-title":"Association between waist circumference and female infertility in the United States","volume":"18","author":"Ke","year":"2023","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.rbmo.2015.03.007","article-title":"The impact of food intake and social habits on embryo quality and the likelihood of blastocyst formation","volume":"31","author":"Braga","year":"2015","journal-title":"Reprod Biomed Online"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12937-022-00812-x","article-title":"Food groups and nutrients consumption and risk of endometriosis: a systematic review and meta-analysis of observational studies","volume":"21","author":"Arab","year":"2022","journal-title":"Nutr J"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.3390\/nu15051180","article-title":"The influence of metabolic factors and diet on fertility","volume":"15","author":"\u0141akoma","year":"2023","journal-title":"Nutrients"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1015566","DOI":"10.3389\/fnut.2022.1015566","article-title":"Red, white, and processed meat consumption related to inflammatory and metabolic biomarkers among overweight and obese women","volume":"9","author":"Shiraseb","year":"2022","journal-title":"Front Nutr"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1017\/S0007114519002149","article-title":"The association of red meat intake with inflammation and circulating intermediate biomarkers of type 2 diabetes is mediated by central adiposity","volume":"125","author":"Mazidi","year":"2021","journal-title":"Br J Nutr"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1476784\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:56:27Z","timestamp":1728435387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1476784\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":32,"alternative-id":["10.3389\/fnut.2024.1476784"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1476784","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"article-number":"1476784"}}