{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:46:35Z","timestamp":1791589595021,"version":"4.3.4"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a newly developed lipid parameter. However, the current research has only explored the relationship with lumbar spine bone mineral density, lacking studies on bone mineral density at other sites, total body bone mineral density, and an analysis of risk factors. This study aims to determine the potential association between NHHR and lumbar BMD, increase awareness of the impact of lipid levels on bone health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>By utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018, we conducted univariate and generalized linear models (GLMs) analysis, stratified analysis, threshold effect analysis, smooth curve fitting and stratified analysis to investigate the association between NHHR and BMD. NHHR levels were categorized into tertiles (low, medium, and high) based on their distribution among the study population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 8,671participants, studies have shown, the ratio of non-high-density lipoprotein to high-density lipoprotein (NHHR) exhibits a stratified correlation with bone mineral density (BMD). In the BMI subgroup, NHHR is significantly negatively correlated with BMD at multiple sites in the low-to-middle BMI group (BMI &amp;lt;25\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), while no significant correlation is found in the high BMI group (BMI \u226530\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). In the gender subgroup, NHHR has a more pronounced effect on male BMD, mainly reflected in the reduction of lumbar spine and total body BMD. In the age subgroup, the negative correlation between NHHR and BMD is strongest in the younger group (18\u201330\u202fyears), gradually weakening in the middle-aged (31\u201344\u202fyears) and older groups (45\u201359\u202fyears). Further analysis suggests that dyslipidemia may influence bone metabolism through pathways such as inflammation and oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The effect of NHHR on bone mineral density (BMD) varies by BMI, gender, and age. This study suggests that controlling NHHR levels may be a potential intervention target for bone health management, particularly for individuals with low-to-middle BMI, males, and younger populations. These findings offer a new perspective on the relationship between lipid metabolism and bone metabolism and provide scientific evidence for the development of personalized osteoporosis prevention and treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2024.1486370","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T02:31:08Z","timestamp":1736217068000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["The relationship between non-HDL-C\/HDL-C ratio and bone mineral density: an NHANES study"],"prefix":"10.3389","volume":"11","author":[{"given":"Shuo","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanwang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daodi","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.phrs.2018.06.004","article-title":"Add-on therapy with traditional Chinese medicine: an efficacious approach for lipid metabolism disorders","volume":"134","author":"Zhang","year":"2018","journal-title":"Pharmacol Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.jacc.2012.11.002","article-title":"The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology","volume":"60","author":"Laslett","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s11657-014-0182-3","article-title":"Estimating prevalence of osteoporosis: examples from industrialized countries","volume":"9","author":"Wade","year":"2014","journal-title":"Arch Osteoporos"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3390\/ijms20020298","article-title":"Homeostasis of glucose and lipid in non-alcoholic fatty liver disease","volume":"20","author":"Chao","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"101122","DOI":"10.1016\/j.gendis.2023.101122","article-title":"The role of lipid metabolism in osteoporosis: clinical implication and cellular mechanism","volume":"11","author":"Zhang","year":"2023","journal-title":"Genes Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s11657-019-0602-5","article-title":"Associations between the lipid profile and the lumbar spine bone mineral density and trabecular bone score in elderly Iranian individuals participating in the Bushehr elderly health program: a population-based study","volume":"14","author":"Panahi","year":"2019","journal-title":"Arch Osteoporos"},{"key":"ref7","first-page":"191","article-title":"Lipid profiles as a possible contributor to osteoporosis","volume":"29","author":"Yazdanpanah","year":"2018","journal-title":"Gazi Med J"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s10654-004-1706-8","article-title":"Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women","volume":"19","author":"Orozco","year":"2004","journal-title":"Eur J Epidemiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"412","DOI":"10.5455\/msm.2016.28.412-415","article-title":"Correlation of the lipid profile, BMI and bone mineral density in postmenopausal women","volume":"28","author":"Bijelic","year":"2016","journal-title":"Mater Sociomed"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"398397","DOI":"10.1155\/2014\/398397","article-title":"Relationship between serum total cholesterol level and serum biochemical bone turnover markers in healthy pre- and postmenopausal women","volume":"2014","author":"Jeong","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"237","DOI":"10.14744\/nci.2017.61587","article-title":"Lipid profile and plasma atherogenic index in postmenopausal osteoporosis","volume":"4","author":"Ersoy","year":"2017","journal-title":"North Clin Istanb"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.14260\/jemds\/2016\/290","article-title":"A correlative study on serum lipid profile and osteogenic mineral status in osteoporosis","volume":"5","author":"Lahon","year":"2016","journal-title":"J Evol Med Dent Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"597","DOI":"10.29252\/ijrm.14.9.597","article-title":"Association of lipid profile with bone mineral density in postmenopausal women in Yazd province","volume":"14","author":"Ghadiri-Anari","year":"2016","journal-title":"Int J Reprod Biomed (Yazd)"},{"key":"ref14","article-title":"The epidemiology and pathogenesis of osteoporosis","volume-title":"Endotext","author":"Rosen","year":"2000"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"882241","DOI":"10.3389\/fendo.2022.882241","article-title":"The global burden of osteoporosis, low bone mass, and its related fracture in 204 countries and territories, 1990\u20132019","volume":"13","author":"Shen","year":"2022","journal-title":"Front Endocrinol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.2174\/0929867327666200330142432","article-title":"Osteoporosis: mechanism, molecular target and current status on drug development","volume":"28","author":"Li","year":"2021","journal-title":"Curr Med Chem"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"8182","DOI":"10.3390\/ijms22158182","article-title":"The development of molecular biology of osteoporosis","volume":"22","author":"Gao","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"9465","DOI":"10.3390\/ijms23169465","article-title":"Current status of the diagnosis and Management of Osteoporosis","volume":"23","author":"Aibar-Almaz\u00e1n","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"14583","DOI":"10.3390\/ijms241914583","article-title":"Osteoporosis: molecular pathology, diagnostics, and therapeutics","volume":"24","author":"Adejuyigbe","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1186\/s12891-021-04643-5","article-title":"Association between lipid biomarkers and osteoporosis: a cross-sectional study","volume":"22","author":"Kan","year":"2021","journal-title":"BMCMusculoskelet Disord"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"762","DOI":"10.3390\/medicina57080762","article-title":"Serum osteoprotegerin level is negatively associated with bone mineral density in patients undergoing maintenance hemodialysis","volume":"57","author":"Lu","year":"2021","journal-title":"Medicina (Kaunas) Martini"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"10562","DOI":"10.1021\/acs.jafc.1c03228","article-title":"C study of D omparative HA with different molecular forms for ameliorating osteoporosis by promoting chondrocyte-to-osteoblast transdifferentiation in the growth plate of ovariectomized mice","volume":"69","author":"Zhang","year":"2021","journal-title":"J Food Chem Agric"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1038\/aps.2011.135","article-title":"High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats","volume":"32","author":"You","year":"2011","journal-title":"Acta Pharmacol Sin"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4603","DOI":"10.3892\/mmr.2019.10131","article-title":"Hypercholesterolaemia increases the risk of high-turn-over osteoporosis in men","volume":"19","author":"Zhou","year":"2019","journal-title":"Mol Med Rep"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.ihj.2021.07.013","article-title":"LDL-C, NON-HDL-C and APO-B for cardiovascular risk assessment: looking for the ideal marker","volume":"73","author":"Aggarwal","year":"2021","journal-title":"Indian Heart J"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1161\/CIRCULATIONAHA.104.532499","article-title":"Non\u2013high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men","volume":"112","author":"Pischon","year":"2005","journal-title":"Circulation"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.2337\/diacare.28.8.1916","article-title":"Joint distribution of non- HDL and LDL cholesterol and coronary heart disease risk prediction among individuals with and without diabetes","volume":"28","author":"Liu","year":"2005","journal-title":"Diabetes Care"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/stmcls\/sxab011","article-title":"Impaired bone fracture healing in type 2 diabetes is caused by defective functions of skeletal progenitor cells","volume":"40","author":"Figeac","year":"2022","journal-title":"Stem Cells"},{"key":"ref29","first-page":"3900","article-title":"Research on the correlation of diabetes mellitus complicated with osteoporosis with lipid metabolism, adipokines and inflammatory factors and its regression analysis","volume":"21","author":"Chen","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12902-023-01349-8","article-title":"The correlation of triglyc-eride\/high-density lipoprotein cholesterol ratio with muscle mass in type 2 diabetes patients","volume":"23","author":"Fu","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3892\/ijmm.2024.5385","article-title":"Obesity and lipid metabolism in the development of osteoporosis (review)","volume":"54","author":"Wang","year":"2024","journal-title":"Int J Mol Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1359\/jbmr.1999.14.12.2067","article-title":"Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells","volume":"14","author":"Parhami","year":"1999","journal-title":"J Bone Miner Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3892\/mmr.2015.3472","article-title":"Lipid metabolism disorders and bone dysfunction--interrelated and mutually regulated (review)","volume":"12","author":"Tian","year":"2015","journal-title":"Mol Med Rep"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/j.gendis.2022.07.011","article-title":"Wnt signaling: essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders","volume":"10","author":"Vlashi","year":"2022","journal-title":"Genes Dis"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3390\/pharmaceutics16040485","article-title":"Vanillin promotes osteoblast differentiation, mineral apposition, and antioxidant effects in pre-osteoblasts","volume":"16","author":"Yun","year":"2024","journal-title":"Pharmaceutics"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11883-024-01254-y","article-title":"Inhibition of the ANGPTL3\/8 complex for the prevention and treatment of atherosclerotic cardiovascular disease","volume":"27","author":"Chan","year":"2024","journal-title":"Curr Atheroscler Rep"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00223-023-01160-6","article-title":"Lipid metabolism, methylation aberrant, and osteoporosis: a multi-omics study based on Mendelian randomization","volume":"114","author":"Zhang","year":"2024","journal-title":"Calcif Tissue Int"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1007\/s00125-011-2219-0","article-title":"Nuclear factor of activated T cells mediates oxidised LDL-induced calcification of vascular smooth muscle cells","volume":"54","author":"Goettsch","year":"2011","journal-title":"Diabetologia"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"29473","DOI":"10.1038\/s41598-024-78926-x","article-title":"Association between triglycerides and lumbar bone mineral density in Chinese patients with osteoporotic fractures: a retrospective cross-sectional study","volume":"14","author":"Zhou","year":"2024","journal-title":"Sci Rep"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"154198","DOI":"10.1016\/j.phymed.2022.154198","article-title":"Puerarin improves OVX-induced osteoporosis by regulating phospholipid metabolism and biosynthesis of unsaturated fatty acids based on serum metabolomics","volume":"102","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"4067812","DOI":"10.1155\/2022\/4067812","article-title":"AGEs\/RAGE promote osteogenic differentiation in rat bone marrow-derived endothelial progenitor cells via MAPK signaling","volume":"2022","author":"Wang","year":"2022","journal-title":"J Diabetes Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"132370","DOI":"10.1016\/j.ijbiomac.2024.132370","article-title":"Bone protective effects of the polysaccharides from Grifola frondosa on ovariectomy-induced osteoporosis in mice via inhibiting PINK1\/Parkin signaling, oxidative stress and inflammation","volume":"270","author":"Liu","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"824812","DOI":"10.3389\/fcell.2022.824812","article-title":"Recent advances in enhancement strategies for osteogenic differentiation of mesenchymal stem cells in bone tissue engineering","volume":"10","author":"Zha","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"108269","DOI":"10.1016\/j.isci.2023.108269","article-title":"Macrophage AMPK \u03b21 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice","volume":"26","author":"Day","year":"2023","journal-title":"iScience"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.7150\/ijbs.14654","article-title":"Class A scavenger receptor exacerbates Osteoclastogenesis by an Interleukin-6-mediated mechanism through ERK and JNK signaling pathways","volume":"12","author":"Guo","year":"2016","journal-title":"Int J Biol Sci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"13411","DOI":"10.18632\/aging.205249","article-title":"Regulatory mechanisms of mi R-212-3p on the secretion of inflammatory factors in monocyte-macrophages and the directed differentiation into osteoclasts in ankylosing spondylitis","volume":"15","author":"Xie","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s10529-023-03358-y","article-title":"Exosomes derived from Eph B2-overexpressing bone marrow mesenchymal stem cells regulate immune balance and repair barrier function","volume":"45","author":"Chu","year":"2023","journal-title":"Biotechnol Lett"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s12944-023-01939-4","article-title":"Association between the non-HDL-cholesterol to HDL- cholesterol ratio and abdominal aortic aneurysm from a Chinese screening program","volume":"22","author":"Lin","year":"2023","journal-title":"Lipids Health Dis"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12944-024-02012-4","article-title":"The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and suicidal ideation in adults: a population-based study in the United States","volume":"23","author":"Qing","year":"2024","journal-title":"Lipids Health Dis"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"931","DOI":"10.5603\/KP.a2015.0086","article-title":"Lipoprotein ratios are better than conventional lipid parameters in predicting coronary heart disease in Chinese Han people","volume":"73","author":"Zhu","year":"2015","journal-title":"Kardiol Pol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1001\/jama.2009.1619","article-title":"Major lipids, apolipoproteins, and risk of vascular disease","volume":"302","author":"Di Angelantonio","year":"2009","journal-title":"JAMA"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1186\/s12872-022-02760-0","article-title":"Which one of LDL-C \/HDL-C ratio and non-HDL-C can better predict the severity of coronary artery disease in STEMI patients","volume":"22","author":"Gao","year":"2022","journal-title":"BMC Cardiovasc Disord"},{"key":"ref53","first-page":"2569","article-title":"Higher non-HDL-cholesterol to HDL-cholesterol ratio is linked to increase in non-alcoholic fatty liver disease: secondary analysis based on a longitudinal study","volume":"13","author":"Gao","year":"2020","journal-title":"Int J Clin Exp Pathol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12944-024-02152-7","article-title":"The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data","volume":"23","author":"Wang","year":"2024","journal-title":"Lipids Health Dis"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"109472","DOI":"10.1016\/j.jnutbio.2023.109472","article-title":"Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia","volume":"123","author":"Mousa","year":"2024","journal-title":"J Nutr Biochem"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"E48","DOI":"10.1152\/ajpendo.00421.2013","article-title":"The atherogenic Scarb1 null mouse model shows a high bone mass phenotype","volume":"306","author":"Martineau","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"111114","DOI":"10.1016\/j.cellsig.2024.111114","article-title":"Uptake of ox-LDL by binding to LRP6 mediates oxidative stress-induced BMSCs senescence promoting obesity-related bone loss","volume":"117","author":"Meng","year":"2024","journal-title":"Cell Signal"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.bbadis.2013.05.033","article-title":"Oxidized low density lipoprotein enhanced RANKL expression in human osteoblast-like cells. Involvement of ERK, NFkappaB and NFAT","volume":"1832","author":"Mazi\u00e8re","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"5030","DOI":"10.1038\/s41598-023-31642-4","article-title":"Determinants of bone mass in older adults with normal- and overweight derived from the crosstalk with muscle and adipose tissue","volume":"13","author":"Walowski","year":"2023","journal-title":"Sci Rep"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"311","DOI":"10.4248\/BR201304002","article-title":"Skeletal blood flow in bone repair and maintenance","volume":"1","author":"Tomlinson","year":"2013","journal-title":"Bone Res"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e0180357","DOI":"10.1371\/journal.pone.0180357","article-title":"Bone tissue, blood lipids and inflammatory profiles in adolescent male athletes from sports contrasting in mechanical load","volume":"12","author":"Agostinete","year":"2017","journal-title":"PLoS One"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s40618-015-0408-1","article-title":"Influence of body weight on bone mass, architecture, and turnover","volume":"39","author":"Iwaniec","year":"2016","journal-title":"J Endocrinol Investig"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.3390\/ijms24032556","article-title":"The long way of oxytocin from the uterus to the heart in 70 years from its discovery","volume":"24","author":"Camerino","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e14625","DOI":"10.1111\/cbdd.14625","article-title":"Arctigenin modulates Adipogenic-osteogenic balance in the bone marrow microenvironment of Ovariectomized rats via the MEK1\/PPAR\u03b3\/Wnt\/\u03b2-catenin pathway","volume":"104","author":"Li","year":"2024","journal-title":"Chem Biol Drug Des"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1486370\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T02:31:12Z","timestamp":1736217072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1486370\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":64,"alternative-id":["10.3389\/fnut.2024.1486370"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1486370","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"article-number":"1486370"}}