{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:04:36Z","timestamp":1792598676036,"version":"4.5.0"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The present study was conducted to investigate the effects of PMIX, a polyphenol-rich extract mixture from chestnut wood and olive, on growth performance, hematological parameters, immunity in serum and skin mucus, hepatic antioxidant enzymes, and intestinal cytokine expression in rainbow trout (<jats:italic>Oncorhynchus mykiss<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four experimental diets containing 0 g PMIX kg<jats:sup>\u22121<\/jats:sup> diet (control, C), 0.5 g PMIX kg<jats:sup>\u22121<\/jats:sup> diet (P0.5), 1 g PMIX kg<jats:sup>\u22121<\/jats:sup> diet (P1), and 2 g PMIX kg<jats:sup>\u22121<\/jats:sup> diet (P2) were fed to rainbow trout in an eight-week feeding trial. Triplicate groups of fish received each treatment. Growth performance, feed conversion ratio, protein efficiency, hepatosomatic and viscerosomatic indices, hematological parameters, immunity markers, hepatic antioxidant enzyme activities, and intestinal cytokine expression were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PMIX supplementation significantly improved feed conversion ratios, while groups P0.5 and P1 evidenced an increase in growth performance along with protein efficiency ratios. It also showed decreased hepatosomatic and viscerosomatic indices in the P1 group. Except for higher percentages of monocytes in P0.5 and P1, most hematological parameters of the fish did not differ from that of the control. Serum lysozyme and respiratory burst activities were heightened in all PMIX-treated groups, and the skin mucus lysozyme activity was enhanced in P1. The blood phagocytic activity and phagocytic index, serum immunoglobulin, total protein, and bactericidal activity against <jats:italic>A. hydrophila<\/jats:italic> did not change. Hepatic superoxide dismutase activity significantly increased in P1 and P2, even though catalase activity did not change. Intestinal interleukin-6 expression was upregulated in all PMIX-treated groups, while tumor necrosis factor-alpha and interleukin-1 beta were upregulated in P1, P2, and P0.5 respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The present results evidence that dietary polyphenols from chestnut wood and olive extracts enhance growth performance, antioxidant capacity, and several immunological parameters in the blood, skin mucus, and intestine of rainbow trout. A suitable supplementation level was 1 g PMIX kg<jats:sup>\u22121<\/jats:sup> diet to separate these improvements.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1487209","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T04:27:06Z","timestamp":1733372826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Polyphenol-rich extracts enhance growth, immune function, and antioxidant defense in juvenile rainbow trout (Oncorhynchus mykiss)"],"prefix":"10.3389","volume":"11","author":[{"given":"Aghil","family":"Mansoori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Allaf Noveirian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Hoseinifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirmasoud","family":"Sajjadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem","family":"Ashouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Imperatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Paolucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"ref1","volume-title":"In brief to the state of world fisheries and aquaculture 2024","year":"2024"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"8773","DOI":"10.3390\/app12178773","article-title":"Recent trends and economic aspects in the rainbow trout (Oncorhynchus mykiss) sector","volume":"12","author":"D\u2019Agaro","year":"2022","journal-title":"Appl Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"5432497","DOI":"10.1155\/2018\/5432497","article-title":"Maintenance of fish health in aquaculture: review of epidemiological approaches for prevention and control of infectious disease of fish","volume":"2018","author":"Assefa","year":"2018","journal-title":"Vet Med Int"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1111\/raq.12565","article-title":"Stress management in aquaculture: a review of dietary interventions","volume":"13","author":"Ciji","year":"2021","journal-title":"Rev Aquac"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.3390\/ani14182692","article-title":"Current challenges of vaccination in fish health management","volume":"14","author":"Kumar","year":"2024","journal-title":"Animals"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.15386\/mpr-1742","article-title":"Antibiotics in the environment: causes and consequences","volume":"93","author":"Polianciuc","year":"2020","journal-title":"Med Pharm Rep"},{"key":"ref7","first-page":"707","volume-title":"Beneficial roles of nutrients as immunostimulants in aquaculture: a review, aquaculture and fisheries","author":"Vijayaram","year":"2024"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.3390\/nu16152550","article-title":"Polyphenols: secondary metabolites with a biological impression","volume":"16","author":"Bolat","year":"2024","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"13874","DOI":"10.3390\/ijms241813874","article-title":"Polyphenols in plants: structure, biosynthesis, abiotic stress regulation, and practical applications (review)","volume":"24","author":"Zagoskina","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"708","DOI":"10.3390\/antiox10050708","article-title":"Diet-derived antioxidants and their role in inflammation, obesity and gut microbiota modulation","volume":"10","author":"Deledda","year":"2021","journal-title":"Antioxidants"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.3390\/biomedicines11072078","article-title":"Current understanding of polyphenols to enhance bioavailability for better therapies","volume":"11","author":"Aatif","year":"2023","journal-title":"Biomedicines"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"4419","DOI":"10.1080\/87559129.2022.2026376","article-title":"Polyphenols: a first evidence in the synergism and bioactivities","volume":"39","author":"Mitra","year":"2023","journal-title":"Food Rev Intl"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/ani13010167","article-title":"Dietary supplementation with a blend of Hydrolyzable and condensed tannins ameliorates diet-induced intestinal inflammation in zebrafish (Danio rerio)","volume":"13","author":"Imperatore","year":"2023","journal-title":"Animals"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.3390\/ani11061538","article-title":"Chestnut Shell tannins: effects on intestinal inflammation and Dysbiosis in zebrafish","volume":"11","author":"Orso","year":"2021","journal-title":"Animals"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"4012","DOI":"10.1111\/are.13223","article-title":"The efficacy of dietary curcumin on growth performance, lipid peroxidation and hepatic transcription factors in rainbow trout Oncorhynchus mykiss (Walbaum) reared under different stocking densities","volume":"48","author":"Akdemir","year":"2017","journal-title":"Aquac Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.fsi.2019.03.038","article-title":"Effects of curcumin on haematological values, immunity, antioxidant status and resistance of rainbow trout (Oncorhynchus mykiss) against Aeromonas salmonicida subsp. achromogenes","volume":"89","author":"Yonar","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1111\/anu.13387","article-title":"Growth performance, immune response, antioxidant capacity and disease resistance against Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss) as influenced through singular or combined consumption of resveratrol and two-strain probiotics","volume":"27","author":"Naderi Farsani","year":"2021","journal-title":"Aquac Nutr"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.aquaculture.2013.01.008","article-title":"Effect of black cumin seed oil (Nigella sativa) and nettle extract (quercetin) on enhancement of immunity in rainbow trout, Oncorhynchus mykiss (Walbaum)","author":"Awad","year":"2013","journal-title":"Aquaculture"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"233","DOI":"10.2478\/aoas-2020-0064","article-title":"Effects of dietary pomegranate peel meal on the growth performance, blood indices, and innate immune response of rainbow trout (Oncorhynchus mykiss)","volume":"21","author":"Avazeh","year":"2021","journal-title":"Ann Anim Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/fishes4010018","article-title":"Chestnut shell extract modulates immune parameters in the rainbow trout Oncorhynchus mykiss","volume":"4","author":"Coccia","year":"2019","journal-title":"Aust Fish"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.fsi.2020.02.067","article-title":"Humoral and skin mucosal immune parameters, intestinal immune related genes expression and antioxidant defense in rainbow trout (Oncorhynchus mykiss) fed olive (Olea europea L.) waste","volume":"100","author":"Hoseinifar","year":"2020","journal-title":"Fish Shellfish Immunol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"737955","DOI":"10.1016\/j.aquaculture.2022.737955","article-title":"Beneficial role of polyphenols as feed additives on growth performances, immune response and antioxidant status of Lates Calcarifer (Bloch, 1790) juveniles","volume":"552","author":"Ahmadi","year":"2022","journal-title":"Aquaculture"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"734790","DOI":"10.1016\/j.aquaculture.2019.734790","article-title":"Effects of dietary polyphenols from agricultural by-products on mucosal and humoral immune and antioxidant responses of convict cichlid (Amatitlania nigrofasciata)","volume":"517","author":"Hoseinifar","year":"2020","journal-title":"Aquaculture"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"735494","DOI":"10.1016\/j.aquaculture.2020.735494","article-title":"Effects of dietary polyphenols on mucosal and humoral immune responses, antioxidant defense and growth gene expression in beluga sturgeon (Huso huso)","volume":"528","author":"Safari","year":"2020","journal-title":"Aquaculture"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"734709","DOI":"10.1016\/j.aquaculture.2019.734709","article-title":"Dietary supplementation of polyphenols positively affects the innate immune response, oxidative status, and growth performance of common carp, Cyprinus carpio L","volume":"517","author":"Jahazi","year":"2020","journal-title":"Aquaculture"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.aquaculture.2019.03.041","article-title":"Explants of Oncorhynchus mykiss intestine to detect bioactive molecules uptake and metabolic effects: applications in aquaculture","volume":"506","author":"Coccia","year":"2019","journal-title":"Aquaculture"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.fsi.2020.12.008","article-title":"Insect (black soldier fly, Hermetia illucens) meal supplementation prevents the soybean meal-induced intestinal enteritis in rainbow trout and health benefits of using insect oil","volume":"109","author":"Kumar","year":"2021","journal-title":"Fish Shellfish Immunol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3354\/dao041043","article-title":"Changes in hydrolytic enzyme activities of na\u00efve Atlantic salmon Salmo salar skin mucus due to infection with the Salmon louse Lepeophtheirus salmons and cortisol implantation","volume":"41","author":"Ross","year":"2000","journal-title":"Dis Aquat Org"},{"key":"ref29","first-page":"101","article-title":"Lysozyme assays","volume-title":"Techniques in fish immunology","author":"Ellis","year":"1990"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3147\/jsfp.25.93","article-title":"The immunomodulatory effects of levamisole on rainbow trout, Oncorhynchus mykiss","volume":"25","author":"Kajita","year":"1990","journal-title":"Fish Pathol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s40995-017-0303-0","article-title":"Aqueous extract of Heracleum persicum Desf. Enhances immune response of common carp, Cyprinus carpio, and protection against Aeromonas hydrophila","volume":"41","author":"Soltanian","year":"2017","journal-title":"Iran J Sci Technol Trans A: Sci"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.fsi.2019.12.009","article-title":"Ameliorative effects of dietary Chlorella vulgaris and \u03b2-glucan against diazinon-induced toxicity in Nile tilapia (Oreochromis niloticus)","volume":"96","author":"Abdelhamid","year":"2020","journal-title":"Fish Shellfish Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1111\/j.1095-8649.1972.tb05704.x","article-title":"The haematological assessment of the health of freshwater fish","volume":"4","author":"Blaxhall","year":"1972","journal-title":"J Fish Biol"},{"key":"ref34","first-page":"105","article-title":"Nonspecific defense mechanisms assay in fish: II. Potential killing activity of neutrophils and macrophages, lysozyme activity in serum and organs and total immunoglobulin level in serum","volume-title":"Fish disease diagnosis and prevention methods","author":"Siwicki","year":"1993"},{"key":"ref35","first-page":"367","article-title":"Spectrophotometric assays of antioxidants","volume-title":"Oxidative stress in aquatic ecosystems","author":"Regoli","year":"2012"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0300-9084(75)80147-7","article-title":"Enzymatic and non-enzymatic assay of superoxide dismutase","volume":"57","author":"Fried","year":"1975","journal-title":"Biochimie"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1021\/mp700151b","article-title":"Terpenoids: opportunities for the biosynthesis of natural product drugs using engineered microorganisms","volume":"5","author":"Ajikumar","year":"2008","journal-title":"Mol Pharm"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"101532","DOI":"10.1016\/j.aqrep.2023.101532","article-title":"Effects of dietary pomegranate peel supplementation on growth performance and biochemical responses of common carp, Cyprinus carpio, to chronic crowding stress","volume":"30","author":"Yousefi","year":"2023","journal-title":"Aquac Rep"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1017\/S1751731118002458","article-title":"Effects of resveratrol and genistein on growth, nutrient utilization and fatty acid composition of rainbow trout","volume":"13","author":"Torno","year":"2019","journal-title":"Animal"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s10695-018-0585-y","article-title":"Dietary cosupplementation with curcumin and different selenium sources (nanoparticulate, organic, and inorganic selenium): influence on growth performance, body composition, immune responses, and glutathione peroxidase activity of rainbow trout (Oncorhynchus mykiss)","volume":"45","author":"Kohshahi","year":"2019","journal-title":"Fish Physiol Biochem"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"734638","DOI":"10.1016\/j.aquaculture.2019.734638","article-title":"Influence of dietary sodium alginate and Pediococcus acidilactici on liver antioxidant status, intestinal lysozyme gene expression, histomorphology, microbiota, and digestive enzymes activity, in Asian sea bass (Lates calcalifer) juveniles","volume":"518","author":"Ashouri","year":"2020","journal-title":"Aquaculture"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s10695-019-00716-4","article-title":"Administration of grape (Vitis vinifera) seed extract to rainbow trout (Oncorhynchus mykiss) modulates growth performance, some biochemical parameters, and antioxidant-relevant gene expression","volume":"46","author":"Mousavi","year":"2020","journal-title":"Fish Physiol Biochem"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/jwas.12669","article-title":"Use of grape pomace in formulated feed for the rainbow trout fry, Oncorhynchus mykiss (Walbaum, 1792)","volume":"51","author":"Pe\u00f1a","year":"2020","journal-title":"J World Aquac Soc"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"736896","DOI":"10.1016\/j.aquaculture.2021.736896","article-title":"Different effects of two dietary levels of tea polyphenols on the lipid deposition, immunity and antioxidant capacity of juvenile GIFT tilapia (Oreochromis niloticus) fed a high-fat diet","volume":"542","author":"Qian","year":"2021","journal-title":"Aquaculture"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1080\/23308249.2020.1818689","article-title":"Benefits of dietary polyphenols and polyphenol-rich additives to aquatic animal health: an overview","volume":"29","author":"Ahmadifar","year":"2021","journal-title":"Rev Fish Sci Aquac"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1080\/14786419.2014.903479","article-title":"Extracts deriving from olive mill waste water and their effects on the liver of the goldfish Carassius auratus fed with hypercholesterolemic diet","volume":"28","author":"Alesci","year":"2014","journal-title":"Nat Prod Res"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.fct.2011.03.045","article-title":"Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL\/6 mice","volume":"49","author":"Noh","year":"2011","journal-title":"Food Chem Toxicol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"376","DOI":"10.5829\/idosi.wjfms.2012.04.04.61297","article-title":"Hematological changes in Nile tilapia (Oreochromis niloticus) fed with varying dietary maltose levels","volume":"4","author":"Ighwela","year":"2012","journal-title":"World J Fish Marine Sci"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1026651","DOI":"10.3389\/fmars.2022.1026651","article-title":"Effects of dietary methanolic extract of hyssop, Hyssopus officinalis, on growth performance, hepatic antioxidant, humoral and intestinal immunity, and intestinal bacteria of rainbow trout, Oncorhynchus mykiss","volume":"9","author":"Yousefi","year":"2022","journal-title":"Front Mar Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"146","DOI":"10.24272\/j.issn.2095-8137.2019.035","article-title":"Specific function and modulation of teleost monocytes\/macrophages: polarization and phagocytosis","volume":"40","author":"Lu","year":"2019","journal-title":"Zool Res"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.fsi.2019.07.025","article-title":"Plant extract-based diets differently modulate immune responses and resistance to bacterial infection in striped catfish (Pangasianodon hypophthalmus)","volume":"92","author":"Nhu","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.fsi.2018.07.027","article-title":"Effects of dietary 1, 8-cineole supplementation on physiological, immunological and antioxidant responses to crowding stress in rainbow trout (Oncorhynchus mykiss)","volume":"81","author":"Taheri Mirghaed","year":"2018","journal-title":"Fish Shellfish Immunol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1111\/j.1365-2761.2009.01100.x","article-title":"Use of garlic, Allium sativum, to control Aeromonas hydrophila infection in rainbow trout, Oncorhynchus mykiss (Walbaum)","volume":"32","author":"Nya","year":"2009","journal-title":"J Fish Dis"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.fsi.2012.11.003","article-title":"Azadirachta indica (neem) leaf dietary effects on the immunity response and disease resistance of Asian seabass, Lates calcarifer challenged with Vibrio harveyi","volume":"34","author":"Talpur","year":"2013","journal-title":"Fish Shellfish Immunol"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.aaf.2021.12.008","article-title":"Antimicrobial roles of phagocytosis in teleost fish: phagocytic B cells vs professional phagocytes","author":"Wu","year":"2022","journal-title":"Aquac Fish"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"3403","DOI":"10.1590\/0001-3765201820170730","article-title":"Oxidative stress and fish immune system: phagocytosis and leukocyte respiratory burst activity","volume":"90","author":"Biller","year":"2018","journal-title":"An Acad Bras Cienc"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1177\/1087057111421623","article-title":"Structural alerts for predicting clastogenic activity of pro-oxidant flavonoid compounds","volume":"17","author":"Yordi","year":"2012","journal-title":"J Biomol Screen"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.fsi.2020.07.010","article-title":"Dietary inclusion of chestnut (Castanea sativa) polyphenols to Nile tilapia reared in biofloc technology: impacts on growth, immunity, and disease resistance against Streptococcus agalactiae","volume":"105","author":"Van Doan","year":"2020","journal-title":"Fish Shellfish Immunol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.fsi.2009.03.016","article-title":"The effect of Euglena viridis on immune response of rohu, Labeo rohita (ham.)","volume":"26","author":"Das","year":"2009","journal-title":"Fish Shellfish Immunol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.fsi.2004.09.006","article-title":"Innate immunity of fish","volume":"20","author":"Magnodottir","year":"2006","journal-title":"Fish Shellfish Immunol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1365-2109.2007.01883.x","article-title":"Lysozyme: an important defence molecule of fish innate immune system","volume":"39","author":"Saurabh","year":"2008","journal-title":"Aquac Res"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"428","DOI":"10.22092\/ijfs.2019.118393","article-title":"Comparison of the adjuvant effect of propolis and Freund on the efficacy of Aeromonas hydrophila vaccine in common carp (Cyprinus carpio)","volume":"18","author":"Alishahi","year":"2019","journal-title":"Iran J Fish Sci"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"735361","DOI":"10.1016\/j.aquaculture.2020.735361","article-title":"Effects of feeding with red algae (Laurencia caspica) hydroalcoholic extract on antioxidant defense, immune responses, and immune gene expression of kidney in rainbow trout (Oncorhynchus mykiss) infected with Aeromonas hydrophila","volume":"526","author":"Kiadaliri","year":"2020","journal-title":"Aquaculture"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"412","DOI":"10.3390\/ani13030412","article-title":"Effects of dietary glycine supplementation on growth performance, immunological, and erythrocyte antioxidant parameters in common carp, Cyprinus carpio","volume":"13","author":"Abbasi","year":"2023","journal-title":"Animals"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"4853","DOI":"10.1039\/D0FO00937G","article-title":"Agriculture waste valorisation as a source of antioxidant phenolic compounds within a circular and sustainable bioeconomy","volume":"11","author":"Jimenez-Lopez","year":"2020","journal-title":"Food Funct"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"101378","DOI":"10.1016\/j.aqrep.2022.101378","article-title":"Alleviation of transportation-induced stress in Nile tilapia, Oreochromis niloticus, using brackish water","volume":"27","author":"Yousefi","year":"2022","journal-title":"Aquac Rep"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1042063","DOI":"10.3389\/fvets.2022.1042063","article-title":"Effects of dietary hyssop, Hyssopus officinalis, extract on physiological and antioxidant responses of rainbow trout, Oncorhynchus mykiss, juveniles to thermal stress","volume":"9","author":"Yousefi","year":"2022","journal-title":"Front Vet Sci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/978-3-030-85420-1_12","article-title":"Mucosal immunity in fish","volume-title":"Principles of fish immunology: From cells and molecules to host protection","author":"Salinas","year":"2022"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"91","DOI":"10.22034\/ijab.v8i2.839","article-title":"Effects of dietary olive leaf extract on intestinal immune-related gene expressions in common carp, Cyprinus carpio","volume":"8","author":"Rajabiesterabadi","year":"2020","journal-title":"Int J Aquatic Biol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.fsi.2019.04.036","article-title":"Effect of symbiotic supplemented diet on innate-adaptive immune response, cytokine gene regulation and antioxidant property in Labeo rohita against Aeromonas hydrophila","volume":"89","author":"Devi","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/jez.2555","article-title":"Histopathological damage and stress-and immune-related genes' expression in the intestine of common carp, Cyprinus carpio exposed to copper and polyvinyl chloride microparticle","volume":"337","author":"Hoseini","year":"2022","journal-title":"J. Exp. Zool. Part A"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/are.13440","article-title":"Evaluation of some intestinal cytokines genes expression and serum innate immune parameters in common carp (Cyprinus carpio) fed dietary loquat (Eriobotrya japonica) leaf extract","volume":"49","author":"Hoseinifar","year":"2018","journal-title":"Aquac Res"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"478","DOI":"10.2203\/dose-response.09-015.Mukherjee","article-title":"Dose-dependency of resveratrol in providing health benefits","volume":"8","author":"Mukherjee","year":"2010","journal-title":"Dose Response"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12562-020-01476-4","article-title":"Fish cytokines: current research and applications","volume":"87","author":"Sakai","year":"2021","journal-title":"Fisheries Sci"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.fsi.2019.06.056","article-title":"Effects of probiotic supplementation of a plant-based protein diet on intestinal microbial diversity, digestive enzyme activity, intestinal structure, and immunity in olive flounder (Paralichthys olivaceus)","volume":"92","author":"Jang","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"e0223428","DOI":"10.1371\/journal.pone.0223428","article-title":"The effect of dietary supplementation with Clostridium butyricum on the growth performance, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus)","volume":"14","author":"Li","year":"2019","journal-title":"PLoS One"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"738878","DOI":"10.1016\/j.aquaculture.2022.738878","article-title":"Anti-inflammatory and immunostimulant effect of different timing-related administration of dietary polyphenols on intestinal inflammation in zebrafish, Danio rerio","volume":"563","author":"Imperatore","year":"2023","journal-title":"Aquaculture"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/md19010022","article-title":"Synergistic effect of biosynthesized silver nanoparticles and natural phenolic compounds against drug-resistant fish pathogens and their cytotoxicity: an in vitro study","volume":"19","author":"Essawy","year":"2021","journal-title":"Mar Drugs"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1111\/are.15234","article-title":"Synergistic inhibition effects of tea polyphenols as adjuvant of oxytetracycline on Vibrio parahaemolyticus and enhancement of Vibriosis resistance of Exopalaemon carinicauda","volume":"52","author":"Guo","year":"2021","journal-title":"Aquac Res"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1111\/are.14491","article-title":"Effects of dietary tryptophan levels and fish stocking density on immunological and antioxidant responses and bactericidal activity against Aeromonas hydrophila in rainbow trout (Oncorhynchus mykiss)","volume":"51","author":"Hoseini","year":"2020","journal-title":"Aquac Res"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1080\/23308249.2020.1795616","article-title":"Oxidative stress and antioxidant defense in fish: the implications of probiotic, prebiotic, and synbiotics","volume":"29","author":"Hoseinifar","year":"2021","journal-title":"Rev Fish Sci Aquac"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/raq.12365","article-title":"Sustainable aquaculture requires environmental\u2010friendly treatment strategies for fish diseases","volume":"12","author":"Lieke","year":"2020","journal-title":"Reviews in Aquaculture"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/biom14020221","article-title":"Polyphenols: Role in Modulating Immune Function and Obesity","volume":"14","author":"Mamum","year":"2024","journal-title":"Biomolecules"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1080\/23308249.2020.1818689","article-title":"Benefits of dietary polyphenols and polyphenol-rich additives to aquatic animal health: an overview","volume":"29","author":"Ahmadifar","year":"2021","journal-title":"Reviews in Fisheries Science & Aquaculture"},{"key":"ref89","first-page":"1264074","article-title":"Regulation of immune function by polyphenols","author":"Ding","year":"2018","journal-title":"Journal of immunology research"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3390\/ani11082167","article-title":"The gene regulatory roles of herbal extracts on the growth, immune system, and reproduction of fish","volume":"11","author":"Ahmadifar","year":"2021","journal-title":"Animals"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1487209\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T04:27:13Z","timestamp":1733372833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1487209\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":90,"alternative-id":["10.3389\/fnut.2024.1487209"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1487209","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]},"article-number":"1487209"}}