{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:43:20Z","timestamp":1793065400067,"version":"4.5.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A2074"],"award-info":[{"award-number":["U21A2074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62375115"],"award-info":[{"award-number":["62375115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>A complicated scenario where \u201cmultiple disease threats coexist and multiple health influencing factors are intertwined\u201d is demonstrated by the fact that dental caries, obesity myopia and scoliosis have emerged as global public health issues. The problem of diseases co-existing in living things can be resolved by using probiotics. <jats:italic>Lactobacillus plantarum<\/jats:italic>, has gained attention recently due to its probiotic properties, useful traits, and potential medical applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Examining the anti-obesity and anti-caries effects of <jats:italic>L. plantarum<\/jats:italic> ATCC 14917 on dental caries and obese rat models caused by a high-fat and high-sugar diet is the aim of this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic>, we assessed the <jats:italic>L. plantarum<\/jats:italic> strain\u2019s probiotic properties, such as its antibacterial activity and ability to build biofilms, to determine its ability to inhibit <jats:italic>Streptococcus mutans<\/jats:italic>. Prior to the <jats:italic>in vivo<\/jats:italic> experiment, the subsist test for <jats:italic>L. plantarum<\/jats:italic> ATCC 14917 was carried out by mimicking its capacity to lower blood sugar and blood lipid levels as well as its tolerance to gastrointestinal disorders. In order to assess the health promotion effect of <jats:italic>L. plantarum in vivo<\/jats:italic>. Three-week-old rats were fed a high-sugar, high-fat diet for 8\u202fweeks. They were split into three groups: the control group (Control), the caries and obesity group (CA _OB) and the caries and obesity treated with <jats:italic>L. plantarum<\/jats:italic> ATCC14917 group (LP). <jats:italic>L. plantarum<\/jats:italic> ATCC 14917 was applied during the experiment, and the associated indices were then thoroughly assessed. These included the use of Mirco-CT to calculate the enamel volume, the staining of liver and fat cell sections, serological analysis, and 16S rRNA sequencing of feces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was proved that the <jats:italic>L. plantarum<\/jats:italic> could inhibit the proliferation of <jats:italic>S. mutans<\/jats:italic> and remove dental plaque biofilm in time, which showed the remarkable effects of anti-caries <jats:italic>in vitro<\/jats:italic>. The demineralization rate of enamel decreased by 44.10% due to the inhibition of acid production by pathogenic bacteria. Moreover, In intestinal and stomach juice simulations, <jats:italic>L. plantarum<\/jats:italic> has a high survival rate. The characteristics of bacterial activity in a wide range of pH could degrade triglycerides and glucose <jats:italic>in vitro<\/jats:italic> smoothly. The LP group demonstrated it by reducing animal weight, serum biochemical indices, and HE-stained adipocytes as compared to the CA_OB group. 16S rRNA sequencing data showed that a high-fat and high-sugar diet induced the imbalance of intestinal flora, which showed an increase in microbial abundance, including <jats:italic>unclassified_o__Clostridia_UCG-014<\/jats:italic>, <jats:italic>unclassified_f__Oscillospiraceae<\/jats:italic>, <jats:italic>Turicibacter<\/jats:italic>, <jats:italic>unclassified_f__Lachnospiraceae<\/jats:italic>, <jats:italic>Clostridium_sensu_stricto_1<\/jats:italic>. After the intervention of <jats:italic>L. plantarum<\/jats:italic>, the number of <jats:italic>Lactobacillus<\/jats:italic>, <jats:italic>Limosilactobacillus<\/jats:italic>, <jats:italic>unclassified_f__Muribaculaceae<\/jats:italic>, <jats:italic>Blautia<\/jats:italic>, <jats:italic>Faecalibaculum<\/jats:italic> increased significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therefore, <jats:italic>L. plantarum<\/jats:italic> ATCC 14917 performed the potential of reducing tooth decay and controlling weight gain by a single strain. Support the management of dental caries and obesity, and establish a foundation for future functional food research and development.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2024.1511660","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:11:42Z","timestamp":1735017102000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Study the effect of Lactobacillus plantarum ATCC 14917 for caries prevention and anti-obesity"],"prefix":"10.3389","volume":"11","author":[{"given":"Wei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bairu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongzhao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"9977","DOI":"10.1080\/10408398.2022.2077693","article-title":"Efficacy of probiotics against dental caries in children: a systematic review and meta-analysis","volume":"63","author":"Shi","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1177\/00220345211056247","article-title":"Global burden and inequality of dental caries, 1990 to 2019","volume":"101","author":"Wen","year":"2022","journal-title":"J Dent Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1053\/j.gastro.2020.10.057","article-title":"Metabolism and metabolic disorders and the microbiome: the intestinal microbiota associated with obesity, lipid metabolism, and metabolic health-pathophysiology and therapeutic strategies","volume":"160","author":"Aron-Wisnewsky","year":"2021","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41368-022-00163-7","article-title":"Oral microbiota in human systematic diseases","volume":"14","author":"Peng","year":"2022","journal-title":"Int J Oral Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.tim.2017.09.008","article-title":"Oral biofilms: pathogens, matrix, and Polymicrobial interactions in microenvironments","volume":"26","author":"Bowen","year":"2018","journal-title":"Trends Microbiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e1003661","DOI":"10.1371\/journal.pmed.1003661","article-title":"Associations of obesity and malnutrition with cardiac remodeling and cardiovascular outcomes in Asian adults: a cohort study","volume":"18","author":"Chien","year":"2021","journal-title":"PLoS Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"116127","DOI":"10.1016\/j.jep.2022.116127","article-title":"Role of herbal medicine and gut microbiota in the prevention and treatment of obesity","volume":"305","author":"Zhang","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.11124\/JBISRIR-D-19-00058","article-title":"Obesity and dental caries in early childhood: a systematic review protocol","volume":"18","author":"Manohar","year":"2020","journal-title":"JBI Evid Synth"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s40368-024-00920-8","article-title":"Obesity\/overweight and dental caries experience in children and adolescents: an umbrella review","volume":"25","author":"Garrocho-Rangel","year":"2024","journal-title":"Eur Arch Paediatr Dent"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jpeds.2017.06.050","article-title":"Longitudinal association between obesity and dental caries in adolescents","volume":"189","author":"Li","year":"2017","journal-title":"J Pediatr"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/ipd.12110","article-title":"Overweight and dental caries: the association among German children","volume":"25","author":"Qadri","year":"2015","journal-title":"Int J Paediatr Dent"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3290\/j.ohpd.a37715","article-title":"Caries incidence among obese adolescents: a 3-year prospective study","volume":"15","author":"Basha","year":"2017","journal-title":"Oral Health Prev Dent"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"593734","DOI":"10.3389\/fcimb.2021.593734","article-title":"Firmicutes levels in the mouth reflect the gut condition with respect to obesity and early childhood caries","volume":"11","author":"Rizzardi","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e13582","DOI":"10.7717\/peerj.13582","article-title":"Evaluating a linkage between obesity and the occurrence of dental caries among school going children in Sakaka, Al Jouf, Kingdom of Saudi Arabia","volume":"10","author":"Khattak","year":"2022","journal-title":"PeerJ"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"28","DOI":"10.5144\/0256-4947.2017.31.12.1515","article-title":"Association between body mass index and dental caries among special care female children in Makkah City","volume":"38","author":"Ashour","year":"2018","journal-title":"Ann Saudi Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11050579","article-title":"Exploring the relationship between salivary levels of TNF-\u03b1, Lactobacillus acidophilus, Lactobacillus gasseri, obesity, and caries in early childhood","volume":"11","author":"Leme","year":"2022","journal-title":"Pathogens"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e12960","DOI":"10.1111\/obr.12960","article-title":"Obesity and dental caries in early childhood: a systematic review and meta-analyses","volume":"21","author":"Manohar","year":"2020","journal-title":"Obes Rev"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1186\/s12903-024-04733-5","article-title":"Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and meta-analysis","volume":"24","author":"Bakhoda","year":"2024","journal-title":"BMC Oral Health"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/idj.12259","article-title":"Relationship between body mass index and dental caries in children, and the influence of socio-economic status","volume":"67","author":"Kumar","year":"2017","journal-title":"Int Dent J"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1177\/0022034518767401","article-title":"Structural determinants and Children's Oral health: a cross-National Study","volume":"97","author":"Baker","year":"2018","journal-title":"J Dent Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12903-021-01681-2","article-title":"Determinants of caries experience and the impact on the OHRQOL of 6-year-old Libyan children: a cross-sectional survey","volume":"21","author":"Ballo","year":"2021","journal-title":"BMC Oral Health"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/nu16020267","article-title":"Lactobacillus paracasei JY062 alleviates glucolipid metabolism disorders via the Adipoinsular Axis and gut microbiota","volume":"16","author":"Su","year":"2024","journal-title":"Nutrients"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41368-022-00183-3","article-title":"Periodontitis may induce gut microbiota dysbiosis via salivary microbiota","volume":"14","author":"Bao","year":"2022","journal-title":"Int J Oral Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1093967","DOI":"10.3389\/fcimb.2023.1093967","article-title":"Regulatory effects of oral microbe on intestinal microbiota and the illness","volume":"13","author":"Lu","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3290\/j.ohpd.b2805445","article-title":"Association between early childhood caries and obesity among preschool children","volume":"20","author":"Mohamed","year":"2022","journal-title":"Oral Health Prev Dent"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"104730","DOI":"10.1016\/j.archoralbio.2020.104730","article-title":"Antibiotic-induced dysbiosis of the rat oral and gut microbiota and resistance to Salmonella","volume":"114","author":"Wu","year":"2020","journal-title":"Arch Oral Biol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1120995","DOI":"10.3389\/fcimb.2023.1120995","article-title":"A comprehensive review of the application of probiotics and postbiotics in oral health","volume":"13","author":"Homayouni Rad","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"127289","DOI":"10.1016\/j.micres.2022.127289","article-title":"A novel approach to Lactiplantibacillus plantarum: from probiotic properties to the omics insights","volume":"268","author":"Echegaray","year":"2023","journal-title":"Microbiol Res"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-023-10190-3","article-title":"Lactobacillus acidophilus JYLA-126 ameliorates obesity-associated metabolic disorders by positively regulating the AMPK signaling pathway through the gut-liver Axis","author":"Li","year":"2023","journal-title":"Probiotics Antimicrob Proteins"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9020349","article-title":"Health-promoting role of Lactiplantibacillus plantarum isolated from fermented foods","volume":"9","author":"Garcia-Gonzalez","year":"2021","journal-title":"Microorganisms"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3168\/jds.2019-17092","article-title":"Characterization and evaluation of lactic acid bacteria from indigenous raw milk for potential probiotic properties","volume":"103","author":"Reuben","year":"2020","journal-title":"J Dairy Sci"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10040826","article-title":"The impacts of Lactiplantibacillus plantarum on the functional properties of fermented foods: A review of current knowledge","volume":"10","author":"Yilmaz","year":"2022","journal-title":"Microorganisms"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"872012","DOI":"10.3389\/fcimb.2022.872012","article-title":"Lactobacillus plantarum Disrupts S. mutans-C. Albicans cross-kingdom biofilms","volume":"12","author":"Zeng","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"6337","DOI":"10.1007\/s00253-020-10693-x","article-title":"Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE(\u2212\/\u2212) mice through modulation of proinflammatory cytokines and oxidative stress","volume":"104","author":"Hassan","year":"2020","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1146672","DOI":"10.3389\/fmicb.2023.1146672","article-title":"Supplementation of Lactobacillus plantarum ATCC14917 mitigates non-alcoholic fatty liver disease in high-fat-diet-fed rats","volume":"14","author":"Wen","year":"2023","journal-title":"Front Microbiol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"102667","DOI":"10.1016\/j.anaerobe.2022.102667","article-title":"Antibiotic susceptibility and biofilm-forming ability of Veillonella strains","volume":"78","author":"Li","year":"2022","journal-title":"Anaerobe"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1111\/jcmm.13496","article-title":"Probiotic Lactobacillus sp. inhibit growth, biofilm formation and gene expression of caries-inducing Streptococcus mutans","volume":"22","author":"Wasfi","year":"2018","journal-title":"J Cell Mol Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/fsn3.2662","article-title":"Evaluation of tolerance to artificial gastroenteric juice and fermentation characteristics of Lactobacillus strains isolated from human","volume":"10","author":"Liu","year":"2022","journal-title":"Food Sci Nutr"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11051264","article-title":"Probiotic properties and antioxidant activity in vitro of lactic acid Bacteria","volume":"11","author":"Vougiouklaki","year":"2023","journal-title":"Microorganisms"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"110136","DOI":"10.1016\/j.foodres.2021.110136","article-title":"Functional properties of Lactobacillus casei C24 improved by microencapsulation using multilayer double emulsion","volume":"141","author":"Beldarrain-Iznaga","year":"2021","journal-title":"Food Res Int"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/foods11213476","article-title":"Probiotic properties including the antioxidant and hypoglycemic ability of lactic acid Bacteria from fermented grains of Chinese baijiu","volume":"11","author":"Fan","year":"2022","journal-title":"Food Secur"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"5151","DOI":"10.1039\/D3TB00377A","article-title":"A multifunctional polymeric coating with self-adsorbed, antifouling and in situ remineralization properties for caries management","volume":"11","author":"Chu","year":"2023","journal-title":"J Mater Chem B"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/prd.12393","article-title":"The oral microbiome: role of key organisms and complex networks in oral health and disease","volume":"87","author":"Sedghi","year":"2021","journal-title":"Periodontol 2000"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1177\/00220345810600051201","article-title":"Cariogenicity of human plaque lactobacilli in gnotobiotic rats","volume":"60","author":"Fitzgerald","year":"1981","journal-title":"J Dent Res"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1177\/00220345800590051501","article-title":"Cariogenicity of human oral lactobacilli in hamsters","volume":"59","author":"Fitzgerald","year":"1980","journal-title":"J Dent Res"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2020.05.048","article-title":"The Intermucosal connection between the mouth and gut in commensal Pathobiont-driven colitis","volume":"182","author":"Kitamoto","year":"2020","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1586422","DOI":"10.1080\/20002297.2019.1586422","article-title":"Can oral bacteria affect the microbiome of the gut?","volume":"11","author":"Olsen","year":"2019","journal-title":"J Oral Microbiol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e65991","DOI":"10.1371\/journal.pone.0065991","article-title":"Persistence of the oral probiotic Streptococcus salivarius M18 is dose dependent and megaplasmid transfer can augment their bacteriocin production and adhesion characteristics","volume":"8","author":"Burton","year":"2013","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41387-024-00291-5","article-title":"Association of gastrointestinal microbiome and obesity with gestational diabetes mellitus-an updated globally based review of the high-quality literatures","volume":"14","author":"Li","year":"2024","journal-title":"Nutr Diabetes"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e13409","DOI":"10.1111\/obr.13409","article-title":"Human microbiome and metabolic health: An overview of systematic reviews","volume":"23","author":"Michels","year":"2022","journal-title":"Obes Rev"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102103","article-title":"R. On behalf of the obesity programs of nutrition education, G. Assessment opera, from gut microbiota through Low-grade inflammation to obesity: key players and potential targets","volume":"14","author":"Vetrani","year":"2022","journal-title":"Nutrients"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"20190347","DOI":"10.1259\/dmfr.20190347","article-title":"Validity of micro-CT for in vitro caries detection: a systematic review and meta-analysis","volume":"49","author":"Oliveira","year":"2020","journal-title":"Dentomaxillofac Radiol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"120060","DOI":"10.1016\/j.lfs.2021.120060","article-title":"Gut microbiota: a potential therapeutic target for management of diabetic retinopathy?","volume":"286","author":"Alarc\u00f3n Yemp\u00e9n","year":"2021","journal-title":"Life Sci"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"2190304","DOI":"10.1080\/19490976.2023.2190304","article-title":"Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17\/Treg balance and gut microbiota structure","volume":"15","author":"Guo","year":"2023","journal-title":"Gut Microbes"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e0227886","DOI":"10.1371\/journal.pone.0227886","article-title":"Functional dynamics of bacterial species in the mouse gut microbiome revealed by metagenomic and metatranscriptomic analyses","volume":"15","author":"Chung","year":"2020","journal-title":"PLoS One"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e1800390","DOI":"10.1002\/mnfr.201800390","article-title":"Garcinol reduces obesity in high-fat-diet-fed mice by modulating gut microbiota composition","volume":"63","author":"Lee","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"112027","DOI":"10.1016\/j.intimp.2024.112027","article-title":"Ziyuglycoside II attenuated OVX mice bone loss via inflammatory responses and regulation of gut microbiota and SCFAs","volume":"132","author":"Zhou","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061297","article-title":"Lactobacillus acidophilus DDS-1 modulates intestinal-specific microbiota, short-chain fatty acid and immunological profiles in aging mice","volume":"11","author":"Vemuri","year":"2019","journal-title":"Nutrients"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1038\/s41467-020-18754-5","article-title":"Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD","volume":"11","author":"Lee","year":"2020","journal-title":"Nat Commun"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s40168-022-01430-9","article-title":"Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders","volume":"10","author":"Liu","year":"2022","journal-title":"Microbiome"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7120597","article-title":"Gut anaerobes capable of chicken Caecum colonisation","volume":"7","author":"Kubasova","year":"2019","journal-title":"Microorganisms"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1007\/s10068-024-01621-0","article-title":"Important roles of Ruminococcaceae in the human intestine for resistant starch utilization","volume":"33","author":"Kim","year":"2024","journal-title":"Food Sci Biotechnol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e2004529","DOI":"10.1002\/adma.202004529","article-title":"Prebiotics-encapsulated probiotic spores regulate gut microbiota and suppress Colon Cancer","volume":"32","author":"Zheng","year":"2020","journal-title":"Adv Mater"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"4234","DOI":"10.1016\/j.clnu.2021.01.031","article-title":"Streptococcus and g. Eubacterium_coprostanoligenes_group combined with sphingosine to modulate the serum dyslipidemia in high-fat diet mice","volume":"40","author":"Wei","year":"2021","journal-title":"Clin Nutr"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1228754","DOI":"10.3389\/fimmu.2023.1228754","article-title":"Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications","volume":"14","author":"Luo","year":"2023","journal-title":"Front Immunol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s13679-019-00352-2","article-title":"Understanding the role of the gut microbiome and microbial metabolites in obesity and obesity-associated metabolic disorders: current evidence and perspectives","volume":"8","author":"Vallianou","year":"2019","journal-title":"Curr Obes Rep"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1038\/s41467-022-32015-7","article-title":"Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota","volume":"13","author":"Hosomi","year":"2022","journal-title":"Nat Commun"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41522-019-0101-x","article-title":"Blautia genus associated with visceral fat accumulation in adults 20\u201376 years of age","volume":"5","author":"Ozato","year":"2019","journal-title":"NPJ Biofilms Microbiomes"},{"key":"ref69","article-title":"Clostridia: sporeforming anaerobic bacilli","volume-title":"Medical microbiology","author":"Wells","year":"1996"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"780354","DOI":"10.3389\/fcimb.2022.780354","article-title":"Gut Dysbiosis in ocular mucous membrane pemphigoid","volume":"12","author":"Low","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"756924","DOI":"10.3389\/fphar.2021.756924","article-title":"Phillygenin attenuates carbon tetrachloride-induced liver fibrosis via modulating inflammation and gut microbiota","volume":"12","author":"Wang","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"e0205784","DOI":"10.1371\/journal.pone.0205784","article-title":"Analysis of gut microbiota and the effect of lauric acid against necrotic enteritis in Clostridium perfringens and Eimeria side-by-side challenge model","volume":"14","author":"Yang","year":"2019","journal-title":"PLoS One"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"130622","DOI":"10.1016\/j.ijbiomac.2024.130622","article-title":"The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice","volume":"264","author":"Ye","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011171","article-title":"Supplementation with Lactiplantibacillus plantarum IMC 510 modifies microbiota composition and prevents body weight gain induced by cafeteria diet in rats","volume":"22","author":"Micioni Di Bonaventura","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8040573","article-title":"The controversial role of human gut Lachnospiraceae","volume":"8","author":"Vacca","year":"2020","journal-title":"Microorganisms"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/bs.ampbs.2019.03.001","article-title":"Hydrogenases and H(2) metabolism in sulfate-reducing bacteria of the Desulfovibrio genus","volume":"74","author":"Baffert","year":"2019","journal-title":"Adv Microb Physiol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.molmed.2016.01.002","article-title":"Sulfide as a mucus barrier-breaker in inflammatory bowel disease?","volume":"22","author":"Ijssennagger","year":"2016","journal-title":"Trends Mol Med"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"7897","DOI":"10.1039\/D1FO01152A","article-title":"Punicic acid ameliorates obesity and liver steatosis by regulating gut microbiota composition in mice","volume":"12","author":"Yuan","year":"2021","journal-title":"Food Funct"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1511660\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:11:48Z","timestamp":1735017108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2024.1511660\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":78,"alternative-id":["10.3389\/fnut.2024.1511660"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2024.1511660","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,24]]},"article-number":"1511660"}}