{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T17:43:15Z","timestamp":1767202995507,"version":"build-2238731810"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Geriatric hip fractures, known as osteoporotic fractures, are associated with nutritional deficiencies such as vitamin D (VitD). However, the relationship between other vitamins besides VitD and fracture is still lacking. Therefore, we intended to identify various vitamin levels and deficiencies in elderly patients with hip fractures and compared those with healthy elderly individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 210 geriatric hip fracture continuous patients and 402 healthy elderly individuals aged \u226565\u202fyears old and with complete serum vitamin records were enrolled in this study. The levels of serum VitA, VitB1, VitB2, VitB3, VitB5, VitB6, VitB9, VitE, VitK1, and 25-hydroxyvitamin D (25-HO-VitD) and nutritional markers, such as prognostic nutritional index (PNI), were compared between geriatric hip fracture patients and healthy control. The correlation between vitamin level and the nutritional markers was explored. A multiple linear regression analysis was conducted to assess the association between vitamin levels and hip fracture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The levels of VitA, VitB1, VitB3, VitB5, VitB9, 25-HO-VitD, 25-HO-VitD3, E, and K1 were all lower in the hip fracture group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). More than 80% of older persons suffered 25-HO-VitD deficiency in both healthy and fracture groups. A positive correlation between levels of VitA and nutritional markers existed in the fracture and healthy groups. In regression analysis, the association strength between standardized vitamin levels and fracture was the most significant in VitB9 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.94; 95%CI, \u22121.15 to \u22120.73;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), VitA (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.83; 95%CI, \u22121.04 to \u22120.61;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), and VitK1 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.80; 95%CI, \u22121.02 to \u22120.58;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), with no significant statistic difference found in VitB2, VitB9, 25-HO-VitD2, and 25-HO-VitD3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D deficiency is common in elderly people with or without fracture. The levels of VitA, VitB9, and VitK1, instead of VitD, were much lower in fracture patients than in the healthy control, even controlling age and gender. VitA is a potential target for hip fracture prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2025.1421257","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:21:37Z","timestamp":1738110097000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between vitamin levels and geriatric hip fractures: A cross-sectional study"],"prefix":"10.3389","volume":"12","author":[{"given":"Qifei","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoqiang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e1003180","DOI":"10.1371\/journal.pmed.1003180","article-title":"Incidence of and trends in hip fracture among adults in urban China: a nationwide retrospective cohort study","volume":"17","author":"Zhang","year":"2020","journal-title":"PLoS Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.5312\/wjo.v10.i3.166","article-title":"Changing trends in the mortality rate at 1-year post hip fracture \u2013 a systematic review","volume":"10","author":"Downey","year":"2019","journal-title":"World J Orthop"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e47258","DOI":"10.1136\/bmjopen-2020-047258","article-title":"Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries","volume":"11","author":"Sing","year":"2021","journal-title":"BMJ Open"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1210\/jc.2011-3058","article-title":"Clinical review. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis","volume":"97","author":"Drake","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e1917789","DOI":"10.1001\/jamanetworkopen.2019.17789","article-title":"Vitamin D and calcium for the prevention of fracture: a systematic review and meta-analysis","volume":"2","author":"Yao","year":"2019","journal-title":"JAMA Netw Open"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/S2213-8587(21)00119-4","article-title":"Nutritional intake and bone health","volume":"9","author":"Rizzoli","year":"2021","journal-title":"Lancet Diabetes Endo"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40981-019-0282-6","article-title":"Geriatric nutritional risk index and controlling nutritional status score can predict postoperative 180-day mortality in hip fracture surgeries","volume":"5","author":"Kotera","year":"2019","journal-title":"Ja Clin Rep"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"CD 1880","DOI":"10.1002\/14651858.CD001880.pub3","article-title":"Nutritional supplementation for hip fracture aftercare in older people","volume":"11","author":"Avenell","year":"2016","journal-title":"Cochrane Db Syst Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3390\/nu13020525","article-title":"Do only calcium and vitamin D matter? Micronutrients in the diet of inflammatory bowel disease patients and the risk of osteoporosis","volume":"13","author":"Ratajczak","year":"2021","journal-title":"Nutrients"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3390\/nu14030523","article-title":"The role of macronutrients, micronutrients and flavonoid polyphenols in the prevention and treatment of osteoporosis","volume":"14","author":"Martiniakova","year":"2022","journal-title":"Nutrients"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/B978-012470862-4\/50028-3","article-title":"Osteoporosis","volume-title":"Nutrition and risk for osteoporosis","author":"Heaney","year":"2001"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.rboe.2015.03.008","article-title":"Associations of vitamin D deficiency with postoperative gait and mortality among patients with fractures of the proximal femur","volume":"50","author":"Gumieiro","year":"2015","journal-title":"Rev Bras Ortop"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00223-002-2084-4","article-title":"Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age","volume":"73","author":"Braam","year":"2003","journal-title":"Calcified Tissue Int"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1093\/ajcn\/71.5.1201","article-title":"Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women","volume":"71","author":"Booth","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.3945\/ajcn.112.035741","article-title":"Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore longitudinal ageing study","volume":"96","author":"Ng","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.3945\/ajcn.115.111971","article-title":"Cross-sectional and prospective associations between dietary and plasma vitamin C, heel bone ultrasound, and fracture risk in men and women in the European prospective investigation into Cancer in Norfolk cohort","volume":"102","author":"Finck","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3945\/ajcn.113.064691","article-title":"Intake and serum concentrations of \u03b1-tocopherol in relation to fractures in elderly women and men: 2 cohort studies","volume":"99","author":"Micha\u00eblsson","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e2121106","DOI":"10.1001\/jamanetworkopen.2021.21106","article-title":"Prevalence of osteoporosis and fracture in China: the China osteoporosis prevalence study","volume":"4","author":"Wang","year":"2021","journal-title":"JAMA Netw Open"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"639","DOI":"10.15171\/apb.2016.078","article-title":"Association of Vitamin D Deficiency and Thyroid Function in postmenopausal women","volume":"6","author":"Niafar","year":"2016","journal-title":"Adv Pharm Bull"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.regg.2013.11.004","article-title":"Vitamin D deficiency in a cohort over 65 years: prevalence and association with sociodemographic and health factors","volume":"49","author":"Mateopascual","year":"2014","journal-title":"Rev Esp Geriatr Gerontol"},{"key":"ref21","first-page":"187","article-title":"Bones and nutrition: common sense supplementation for osteoporosis","volume":"3","author":"Advani","year":"2003","journal-title":"Curr Womens Health Rep"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1024\/0300-9831\/a000761","article-title":"Role of vitamin K2 in bone-vascular crosstalk","volume":"94","author":"Merra","year":"2024","journal-title":"Int J Vitam Nutr Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1017\/S0029665108007003","article-title":"Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment","volume":"67","author":"Lanham-New","year":"2008","journal-title":"Proc Nutr Soc"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.3945\/ajcn.2009.28116","article-title":"Low serum folate and vitamin B6 are associated with an altered cancellous bone structure in humans","volume":"90","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.14283\/jpad.2024.165","article-title":"Effects of Vitamin D3 combined with folic acid on domain and specific cognitive function among patients with mild cognitive impairment: a randomized clinical trial","volume":"11","author":"Liu","year":"2024","journal-title":"J Prev Alzheimers Dis"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3390\/nu15010132","article-title":"Folic acid and Vitamin B12 can reverse Vitamin D deficiency-induced learning and memory impairment by altering 27-hydroxycholesterol and S-adenosylmethionine","volume":"15","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1080\/10408398.2016.1160362","article-title":"The vicious cycle of vitamin a deficiency: a review","volume":"57","author":"Wiseman","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"5038","DOI":"10.3390\/nu14235038","article-title":"Immune impairment associated with Vitamin a deficiency: insights from clinical studies and animal model research","volume":"14","author":"Amimo","year":"2022","journal-title":"Nutrients"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"105672","DOI":"10.1016\/j.jsbmb.2020.105672","article-title":"Distribution of free 25OHD in elderly population base 0d on LC-MS\/MS","volume":"200","author":"Wang","year":"2020","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1017\/S0007114514000178","article-title":"Riboflavin (vitamin B2) and oxidative stress: a review","volume":"111","author":"Ashoori","year":"2014","journal-title":"Br J Nutr"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1093\/ajcn\/51.5.859","article-title":"Increased plasma lipid peroxidation in riboflavin-deficient, malaria-infected children","volume":"51","author":"Das","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1111\/febs.14609","article-title":"Thiol disulfide exchange reactions in human serum albumin: the apparent paradox of the redox transitions of Cys 34","volume":"285","author":"Bocedi","year":"2018","journal-title":"FEBS J"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.3945\/ajcn.115.110528","article-title":"No increase in risk of hip fracture at high serum retinol concentrations in community-dwelling older Norwegians: the Norwegian epidemiologic osteoporosis studies","volume":"102","author":"Holvik","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1007\/s00198-004-1618-1","article-title":"No effect of vitamin a intake on bone mineral density and fracture risk in perimenopausal women","volume":"15","author":"Rejnmark","year":"2004","journal-title":"Osteoporos Int"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1017\/S0007114517001180","article-title":"Carotenoid dietary intakes and plasma concentrations are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the European prospective investigation into cancer and nutrition (EPIC)-Norfolk cohort","volume":"117","author":"Hayhoe","year":"2017","journal-title":"Br J Nutr"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.3390\/molecules26061757","article-title":"Vitamin a and bone health: a review on current evidence","volume":"26","author":"Yee","year":"2021","journal-title":"Molecules"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"115630","DOI":"10.1016\/j.bone.2020.115630","article-title":"Serum vitamin K1 (phylloquinone) is associated with fracture risk and hip strength in post-menopausal osteoporosis: a cross-sectional study","volume":"141","author":"Moore","year":"2020","journal-title":"Bone"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.3390\/biomedicines10051048","article-title":"Effect of vitamin K on bone mineral density and fracture risk in adults: systematic review and meta-analysis","volume":"10","author":"Salma","year":"2022","journal-title":"Biomedicines"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1039\/c9fo03063h","article-title":"The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials","volume":"11","author":"Kuang","year":"2020","journal-title":"Food Funct"}],"updated-by":[{"DOI":"10.3389\/fnut.2025.1595419","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000}}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2025.1421257\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T12:32:55Z","timestamp":1743510775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2025.1421257\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":39,"alternative-id":["10.3389\/fnut.2025.1421257"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2025.1421257","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"article-number":"1421257"}}