{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:20:58Z","timestamp":1789586458132,"version":"build-2803163510"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260572"],"award-info":[{"award-number":["82260572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The study aimed to investigate the function and prognosis of pancreatitis in patients with hypertriglyceridemia-associated acute pancreatitis (HTGAP), as assessed by the systemic immunoinflammatory index (SII), nutritional risk index (NRI), and triglyceride-glucose index (TyG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 300 patients with HTGAP who were admitted to the General Hospital of Ningxia Medical University from January 2022 to June 2023 were selected. These patients were divided into three groups based on the severity of their condition: the mild acute pancreatitis (MAP) group, the moderate-to-severe acute pancreatitis (MSAP) group, and the severe acute pancreatitis (SAP) group. The SII, NRI, and TyG index in the three groups were recorded and compared. The value of these indices in predicting the occurrence of HTGAP was analyzed using a receiver operating characteristic (ROC) curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The SII and TyG index values in the SAP group (3259.4 \u00b1 2795.8, 4.5 \u00b1 1.1) were higher than those in the MSAP group (2563.7 \u00b1 1614.1, 4.3 \u00b1 0.8) and MAP group (1991.1 \u00b1 1566.8, 4.1 \u00b1 0.8), and the difference was statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.005). The ROC curve analysis showed that the AUC value of the combined SII, NRI, and TyG index for predicting SAP occurrence was 0.705 (95%CI:0.632\u202f~\u202f0.778).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SII, NRI, and TyG index are related to the severity of HTGAP, and a combination of the three can better predict the occurrence of SAP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2025.1523046","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:10:09Z","timestamp":1738195809000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Value of the systemic immunoinflammatory index, nutritional risk index, and triglyceride-glucose index in predicting the condition and prognosis of patients with hypertriglyceridemia-associated acute pancreatitis"],"prefix":"10.3389","volume":"12","author":[{"given":"Yuan Zhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Ling","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Tun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Feng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Ya","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.19538\/j.cjps.issn1005-2208.2024.05.07","article-title":"Diagnosis and lipid-lowering treatment strategy for hypertriglyceridemic pancreatitis","volume":"22","author":"Wenhua","year":"2022","journal-title":"Chin J Pancreatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.19538\/j.nk2021010103","article-title":"Characteristics and treatment of hypertriglyceridemia acute pancreatitis","volume":"41","author":"Yiqi","year":"2021","journal-title":"Chin J Pract Int Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"460","DOI":"10.4103\/ijn.IJN_476_20","article-title":"Acute kidney injury complicating severe acute pancreatitis: clinical profile and factors predicting 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Hepatol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.3390\/nu13051498","article-title":"Nutritional support in patients with severe acute pancreatitis-current standards","volume":"13","author":"Jab\u0142o\u0144ska","year":"2021","journal-title":"Nutrients"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1080\/08941939.2022.2084187","article-title":"Systemic inflammation response index and systemic immune inflammation index are associated with clinical outcomes in patients with acute pancreatitis?","volume":"35","author":"Biyik","year":"2022","journal-title":"J Invest Srug"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/j.pan.2020.09.018","article-title":"Triglyceride and glucose (TyG) index is an effective biomarker to identify severe acute pancreatitis","volume":"20","author":"Park","year":"2020","journal-title":"Pancreatology"}],"container-title":["Frontiers in 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