{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:42:59Z","timestamp":1784824979181,"version":"3.55.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertension poses an imperative global health risk, affecting over 1 billion people and contributing to cardiovascular disease, especially for women. While previous studies suggest micronutrients such as Vitamin C or Selenium can help reduce blood pressure, research on their interactive effects remains limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross-sectional study analyzed data from 9,343 women aged 20\u202fyears and older in NHANES (2011\u20132020). Logistic regression analysis was conducted to evaluate the effect of each micronutrient on hypertension. To account for potential interactions between micronutrients, we calculated the relative excess risk due to interaction, which assessed their combined effect on hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We confirmed the individual associations of Vitamin C and Selenium with hypertension, showing significant negative correlations (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05). Participants were then divided into four groups, and those with high intakes of both Vitamin C and Selenium had a significantly lower risk of hypertension (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05), supporting the association between the combined intake of these nutrients and lower hypertension risk, though no synergistic effect was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings support the combined intake of Vitamin C and Selenium in hypertension prevention, broadening thoughts on the level of nutrition for the treatment of hypertension. These results suggest a potential association between adequate supplementation of Vitamin C and Selenium and lower blood pressure. However, further rigorous clinical studies are essential to validate and strengthen these findings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1534535","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T05:17:48Z","timestamp":1741843068000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Interactive effect between Selenium and Vitamin C levels on risk of hypertension among adult women in the United States: evidence from NHANES 2011 to 2020"],"prefix":"10.3389","volume":"12","author":[{"given":"Dongfang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze Wan","family":"Ching","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/978-3-031-11665-0_48","article-title":"Hypertension: epidemiology, evaluation, and blood pressure monitoring","volume-title":"Pediatric kidney disease","author":"Macumber","year":"2023"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.jcin.2021.09.020","article-title":"Renal sympathetic denervation: early impact on ambulatory resistant hypertension","volume":"16","author":"Schwerg","year":"2014","journal-title":"J Clin 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2003\u20132014","volume":"7","author":"Kirkland","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1097\/HJH.0000000000001018","article-title":"Associations of blood pressure, sunlight, and vitamin D in community-dwelling adults","volume":"34","author":"Rostand","year":"2016","journal-title":"J Hypertens"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3177\/jnsv.60.239","article-title":"The association between vitamin E intake and hypertension: results from the re-analysis of the National Health and nutrition survey","volume":"60","author":"Kuwabara","year":"2014","journal-title":"J Nutr Sci Vitaminol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1093\/jn\/137.10.2171","article-title":"New developments and novel therapeutic perspectives for vitamin C","volume":"137","author":"Li","year":"2007","journal-title":"J 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cross-sectional and longitudinal population study","volume":"28","author":"Nawrot","year":"2007","journal-title":"Eur Heart J"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1338745","DOI":"10.3389\/fimmu.2024.1338745","article-title":"Association between dietary selenium intake and the prevalence of hypertension: results from the National Health and nutrition examination survey 2003\u20132018","volume":"15","author":"Wu","year":"2024","journal-title":"Front Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2337\/dc10-0879","article-title":"Persistent increase of prevalence of metabolic syndrome among US adults: NHANES III to NHANES 1999\u20132006","volume":"34","author":"Mozumdar","year":"2011","journal-title":"Diabetes Care"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/BF02917198","article-title":"Selenium and cardiovascular disease","volume":"24","author":"Oster","year":"1990","journal-title":"Biol 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