{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:12Z","timestamp":1753891932261,"version":"3.41.2"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Given the ease of access to ambient temperature, it may be a more practical guide than the UVB index. However, the association between gestational temperature and vitamin D level in newborns remains unclear. Our study aims to explore this association and the necessity of maternal vitamin D supplementation when ambient temperature is less than a specific value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on a birth cohort study, we measured cord blood concentrations of 25(OH)D in 1419 neonates from January to September 2008 in Hefei, a new first-tier city in China. The daily mean temperature of Hefei was obtained from the China Meteorological Data Sharing Service System. Individual information on sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes was collected prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The best-fit relationship was observed in the regression model using a quadratic function to describe the association between the ambient temperature of the eighth gestational month (29\u201332 gestational weeks) and cord blood 25(OH)D concentrations (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u202f=\u202f0.358, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001). Ambient temperatures of 10 and 24.5\u00b0C were linked to the cutoff of vitamin D inadequacy (&amp;lt;50\u202fnmol\/L) and deficiency (&amp;lt;30\u202fnmol\/L) in cord blood, respectively. For maternal exposure to an ambient temperature of \u226524.5\u00b0C in the eighth gestational month, vitamin D supplementation during pregnancy failed to significantly enhance neonatal vitamin D concentrations. In contrast, for maternal exposure to ambient temperature of &amp;lt;10\u00b0C, maternal vitamin D supplementation was significantly associated with elevated 25(OH)D concentrations in cord blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gestational ambient temperature may be an ideal predictor for infant vitamin D status screening. Maternal exposure to an ambient temperature of less than 10\u00b0C is a critical index in the eighth gestational month, which may determine the onset of vitamin D supplementation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1541427","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:11:40Z","timestamp":1738041100000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status"],"prefix":"10.3389","volume":"12","author":[{"given":"Wanjun","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.eprac.2024.10.011","article-title":"Revisiting vitamin D guidelines: a critical appraisal of the literature","volume":"30","author":"Holick","year":"2024","journal-title":"Endocr Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/nu14091900","article-title":"Vitamin D: before, during and after pregnancy: effect on neonates and children","volume":"14","author":"Mansur","year":"2022","journal-title":"Nutrients"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1093\/ajcn\/nqaa197","article-title":"Prevalence and correlates of vitamin D deficiency in a tropical setting: results from a nationally representative survey","volume":"112","author":"Beer","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/nu11123042","article-title":"First trimester maternal vitamin D status and risks of preterm birth and small-for-gestational age","volume":"11","author":"Monier","year":"2019","journal-title":"Nutrients"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/ajcn\/nqz260","article-title":"The association of vitamin D status and supplementation during pregnancy with gestational diabetes mellitus: a Chinese prospective birth cohort study","volume":"111","author":"Yin","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"718","DOI":"10.2337\/dci18-0048","article-title":"Metabolic culprits in obese pregnancies and gestational diabetes mellitus: big babies, big twists, big picture: the 2018 Norbert Freinkel award lecture","volume":"42","author":"Barbour","year":"2019","journal-title":"Diabetes Care"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e72261","DOI":"10.7759\/cureus.72261","article-title":"Association between neonatal and maternal vitamin D levels at birth","volume":"16","author":"Jaiswal","year":"2024","journal-title":"Cureus J Med Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/AOG.0b013e318227f06b","article-title":"Vitamin D: screening and supplementation during pregnancy","volume":"118","year":"2011","journal-title":"Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1542\/peds.2008-1862","article-title":"Prevention of rickets and vitamin D deficiency in infants, children, and adolescents","volume":"122","author":"Wagner","year":"2008","journal-title":"Pediatrics"},{"key":"ref10","first-page":"409","article-title":"Updated clinical practice guidelines on pregnancy care","volume-title":"Med J Australia","author":"Homer","year":"2018"},{"volume-title":"Dietary reference intakes for calcium and vitamin D","year":"2011","key":"ref11"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"f1675","DOI":"10.1136\/bmj.f1675","article-title":"Vitamin D sufficiency in pregnancy","volume":"346","author":"Lucas","year":"2013","journal-title":"Brit Med J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocr Metab"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3945\/ajcn.113.065672","article-title":"Effects of maternal serum 25-hydroxyvitamin D concentrations in the first trimester on subsequent pregnancy outcomes in an Australian population","volume":"99","author":"Schneuer","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s40519-016-0312-6","article-title":"Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects","volume":"22","author":"Caprio","year":"2017","journal-title":"Eat Weight Disord-ST"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"New Engl J Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1056\/NEJM199204303261808","article-title":"Vitamin D--solar rays, the milky way, or both?","volume":"326","author":"Haddad","year":"1992","journal-title":"New Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1210\/jc.2010-2704","article-title":"The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know","volume":"96","author":"Ross","year":"2011","journal-title":"J Clin Endocr Metab."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1651-2227.2006.tb02378.x","article-title":"WHO child growth standards based on length\/height, weight and age","volume":"450","year":"2006","journal-title":"Acta Paediatr Suppl"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.clnesp.2022.04.024","article-title":"Association between different levels of maternal vitamin-D status during pregnancy and maternal outcomes","volume":"50","author":"Alanazi","year":"2022","journal-title":"Clin Nutr Espen"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.clnu.2023.04.011","article-title":"Effect of vitamin D supplementation on glucose control in mid-late gestation: a randomized controlled trial","volume":"42","author":"Ma","year":"2023","journal-title":"Clin Nutr"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12884-024-06277-6","article-title":"Effect of early vitamin D supplementation on the incidence of preeclampsia in primigravid women: a randomised clinical trial in eastern Democratic Republic of the Congo","volume":"24","author":"Kabuyanga","year":"2024","journal-title":"BMC Pregnancy Child B"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1530\/EJE-17-0730","article-title":"The impact of environmental temperature on the diagnosis of gestational diabetes mellitus","volume":"178","author":"Vasileiou","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"119211","DOI":"10.1016\/j.envres.2024.119211","article-title":"Relative humidity, temperature, and hypertensive disorders of pregnancy: findings from the project viva cohort","volume":"257","author":"Howe","year":"2024","journal-title":"Environ Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"8052","DOI":"10.1073\/pnas.1500909112","article-title":"High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban southern Africans","volume":"112","author":"Coussens","year":"2015","journal-title":"P Natl Acad Sci USA"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.4161\/derm.15841","article-title":"A review of the role of solar ultraviolet-B irradiance and vitamin D in reducing risk of dental caries","volume":"3","author":"Grant","year":"2011","journal-title":"Dermatoendocrinol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jaci.2010.06.011","article-title":"Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children","volume":"126","author":"Vassallo","year":"2010","journal-title":"J Allergy Clin Immun"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1562\/2004-09-07-ir-308r.1","article-title":"UV doses worldwide","volume":"81","author":"Godar","year":"2005","journal-title":"Photochem Photobiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40985-017-0066-3","article-title":"The importance of vitamin D in maternal and child health: a global perspective","volume":"38","author":"Fiscaletti","year":"2017","journal-title":"Public Health Rev"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"S97","DOI":"10.1079\/bjn2001345","article-title":"Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone","volume":"86","author":"Brot","year":"2001","journal-title":"Brit J Nutr"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1158\/1055-9965.EPI-05-0969","article-title":"Validity and reliability of adult recall of past sun exposure in a case-control study of multiple sclerosis","volume":"15","author":"van der Mei","year":"2006","journal-title":"Cancer Epidem Biomar"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1289\/ehp.9937","article-title":"The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude","volume":"115","author":"van der Mei","year":"2007","journal-title":"Environ Health Persp"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.3390\/ijerph20031973","article-title":"Correlation between UV index, temperature and humidity with respect to incidence and severity of COVID 19 in Spain","volume":"20","author":"Perez-Gilaberte","year":"2023","journal-title":"Int J Env Res Pub He"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s10661-023-12239-w","article-title":"Assessment of spatiotemporal variability of ultraviolet index (UVI) over Kerala, India, using satellite remote sensing (OMI\/AURA) data","volume":"196","author":"Valappil","year":"2024","journal-title":"Environ Monit Assess"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.cell.2018.04.013","article-title":"Vitamin D switches BAF complexes to protect beta cells","volume":"173","author":"Wei","year":"2018","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.metabol.2017.10.001","article-title":"Understanding vitamin D metabolism in pregnancy: from physiology to pathophysiology and clinical outcomes","volume":"86","author":"Karras","year":"2018","journal-title":"Metabolism"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/s0002-9440(10)64162-4","article-title":"The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua","volume":"161","author":"Zehnder","year":"2002","journal-title":"Am J Pathol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"638S","DOI":"10.1093\/ajcn\/61.3.638S","article-title":"Environmental factors that influence the cutaneous production of vitamin D","volume":"61","author":"Holick","year":"1995","journal-title":"Am J Clin Nutr"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"401","DOI":"10.5694\/j.1326-5377.2001.tb143643.x","article-title":"Vitamin D status of women in the Geelong osteoporosis study: association with diet and casual exposure to sunlight","volume":"175","author":"Pasco","year":"2001","journal-title":"Med J Austr"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.clnu.2016.10.008","article-title":"Vitamin D supplementation, cord 25-hydroxyvitamin D and birth weight: findings from the Odense child cohort","volume":"36","author":"Lykkedegn","year":"2017","journal-title":"Clin Nutr"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nutres.2018.11.011","article-title":"Maternal risk factors and newborn infant vitamin D status: a scoping literature review","volume":"63","author":"Laliberte","year":"2019","journal-title":"Nutr Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"973332","DOI":"10.3389\/fnut.2022.973332","article-title":"A bibliometric analysis of global research on vitamin D and reproductive health between 2012 and 2021: learning from the past, planning for the future","volume":"9","author":"Lu","year":"2022","journal-title":"Front Nutr"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2025.1541427\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:11:44Z","timestamp":1738041104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2025.1541427\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":42,"alternative-id":["10.3389\/fnut.2025.1541427"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2025.1541427","relation":{},"ISSN":["2296-861X"],"issn-type":[{"type":"electronic","value":"2296-861X"}],"subject":[],"published":{"date-parts":[[2025,1,28]]},"article-number":"1541427"}}