{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:14:43Z","timestamp":1772918083781,"version":"3.50.1"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the relationship between the Dietary Inflammatory Index (DII), abnormal bowel habits, and systemic serum inflammatory markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 9,880 participants in the National Health and Nutrition Examination Survey (NHANES) 2005\u20132010 were analyzed. The DII was calculated from two 24-h dietary recalls. Bowel habits were assessed using the Bristol Stool Form Scale, and systemic inflammatory markers included AAPR, IBI, NLR, LMR, PNLR, LCR, LA, and PLR. Statistical analyses were performed using R, Zstats, and EmpowerStats to evaluate associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher DII scores were positively associated with abnormal bowel habits, including constipation [<jats:italic>\u03b2<\/jats:italic> (95% CI): 0.11 (0.01\u20130.22)] and diarrhea [<jats:italic>\u03b2<\/jats:italic> (95% CI): 0.42 (0.32\u20130.53)], and with PNLR [<jats:italic>\u03b2<\/jats:italic> (95% CI): 0.01 (0.01\u20130.01)], PNLRQ4 [<jats:italic>\u03b2<\/jats:italic> (95% CI): 0.13 (0.05\u20130.20)], IBI [<jats:italic>\u03b2<\/jats:italic> (95% CI): 0.02 (0.01\u20130.02)], and IBIQ4 [<jats:italic>\u03b2<\/jats:italic> (95% CI): 0.33 (0.25\u20130.42)] (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05). Negative associations were found with AAPR [<jats:italic>\u03b2<\/jats:italic> (95% CI): \u22120.33 (\u22120.60 - \u22120.06)] and AAPRQ4 [<jats:italic>\u03b2<\/jats:italic> (95% CI): \u22120.18 (\u22120.34 - \u22120.01)], while no significant associations were observed with LA, LCR, or LMR. Subgroup analyses confirmed stable associations between DII and both chronic diarrhea and constipation across seven subgroups. Smoothed curve fitting revealed nonlinear relationships. A J-shaped association between DII and chronic constipation was identified in BMI and IBI subgroups. For BMI &amp;gt;30, the breakpoint (K) was 1.89, with ORs of 1.228 (95% CI: 1.097\u20131.375) below and 3.318 (95% CI: 1.531\u20137.191) above this point. In the IBI Q4 subgroup, the breakpoint was 1.96, with ORs of 1.145 (95% CI: 1.013\u20131.294) below and 5.794 (95% CI: 2.359\u201314.228) above. In the diarrhea group, a U-shaped association was observed in the AAPR Q4 population, with a breakpoint of \u22121.312 and ORs of 0.657 (95% CI: 0.478\u20130.901) below and 1.266 (95% CI: 1.057\u20131.518) above.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher DII scores are linked to an increased risk of chronic constipation and diarrhea and are associated with systemic inflammatory markers and factors such as BMI.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1543715","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T05:46:12Z","timestamp":1742967972000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between the dietary inflammatory index, bowel habits, and systemic serum inflammatory markers: insights from NHANES 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for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology","volume":"67","author":"Arasaradnam","year":"2018","journal-title":"Gut"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"856726","DOI":"10.3389\/fnut.2022.856726","article-title":"Dietary inflammatory potential is associated with sarcopenia among chronic kidney disease population","volume":"9","author":"Huang","year":"2022","journal-title":"Front Nutr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"Leaky gut: mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/s0016-5085(98)70137-4","article-title":"In vivo butyrate metabolism and colonic permeability in extensive ulcerative colitis","volume":"115","author":"Den 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