{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:42:55Z","timestamp":1789494175402,"version":"build-2803163510"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the independent and combined effects of prolonged daily sitting time and sleep duration on the risk of constipation, using data from the National Health and Nutrition Examination Survey (NHANES) 2005\u20132010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 6,894 participants were included in the analysis. Daily sitting time and sleep duration were self-reported and categorized as short (&amp;lt;7\u202fh\/day) or long (\u22657\u202fh\/day). Constipation was defined based on stool consistency and frequency using the Bristol Stool Form Scale. Multivariable logistic regression models were used to estimate the odds ratios (ORs) for constipation. A restricted cubic spline analysis was applied to assess the dose\u2013response relationships.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with prolonged daily sitting time and short sleep duration showed a higher risk of constipation compared to those with long sleep duration and short sitting time. In multivariable-adjusted models, long sitting time was positively associated with an increased risk of constipation (OR = 1.424; 95% CI, 1.114\u20131.821), while long sleep duration was associated with a lower constipation risk (OR = 0.725; 95% CI, 0.553\u20130.952). The joint analysis revealed that the combination of short sleep duration and long sitting time was associated with the highest constipation prevalence (OR = 1.975; 95% CI, 1.378\u20132.833).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both prolonged sitting time and insufficient sleep were associated with an increased risk of constipation, especially when combined. These findings underscore the importance of adopting healthier sleep habits and reducing sedentary behavior to lower constipation risk.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1548455","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T14:34:46Z","timestamp":1741876486000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Joint association of daily sitting time and sleep duration with constipation among the US population"],"prefix":"10.3389","volume":"12","author":[{"given":"Yu-Jun","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Zhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Da","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Yun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Fei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00127-024-02729-8","article-title":"Associations between constipation risk and lifestyle, medication use, and affective symptoms in patients with schizophrenia: a multicenter cross-sectional study","volume":"60","author":"Chiang","year":"2024","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jocn.2024.05.030","article-title":"Association between sleep disorders and constipation risk: a systematic review and Meta-analysis","volume":"126","author":"Tian","year":"2024","journal-title":"J Clin Neurosci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e0302430","DOI":"10.1371\/journal.pone.0302430","article-title":"Sleep duration and its association with constipation in patients with diabetes: the Fukuoka diabetes registry","volume":"19","author":"Ohkuma","year":"2024","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"102578","DOI":"10.1016\/j.eclinm.2024.102578","article-title":"Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis","volume":"71","author":"Djurijanto","year":"2024","journal-title":"EClinicalMedicine"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e37114","DOI":"10.1097\/MD.0000000000037114","article-title":"The correlation between gut microbiota and both neurotransmitters and mental disorders: a narrative review","volume":"103","author":"Mhanna","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"109931","DOI":"10.1016\/j.isci.2024.109931","article-title":"Sleep, physical activity, and sedentary behaviors in relation to overall cancer and site-specific cancer risk: a prospective cohort study","volume":"27","author":"Zhang","year":"2024","journal-title":"iScience"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e2350680","DOI":"10.1001\/jamanetworkopen.2023.50680","article-title":"Occupational sitting time, leisure physical activity, and all-cause and cardiovascular disease mortality","volume":"7","author":"Gao","year":"2024","journal-title":"JAMA Netw Open"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"322","DOI":"10.5056\/jnm23134","article-title":"Effect of physical activity on the association between diet and constipation: evidence from the National Health and nutrition examination survey 2007-2010","volume":"30","author":"Lai","year":"2024","journal-title":"J Neurogastroenterol Motil"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"590S","DOI":"10.1093\/jn\/133.2.590S","article-title":"Collection of food and dietary supplement intake data: what we eat in America-NHANES","volume":"133","author":"Dwyer","year":"2003","journal-title":"J Nutr"},{"key":"ref10","volume-title":"Us centers for disease control and prevention, national health and nutrition examination survey 1999-2000, 2001-2002, 2003-2004, 2005-2006, 2011-2012, 2013-2014, 2015-2016, 2017-2018 Documentation Files","year":"2021"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/17474124.2020.1708718","article-title":"An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation","volume":"14","author":"Aziz","year":"2020","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1426280","DOI":"10.3389\/fnut.2024.1426280","article-title":"Association between dietary vitamin E intake and constipation: NHANES 2005-2010","volume":"11","author":"Cai","year":"2024","journal-title":"Front Nutr"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"19237","DOI":"10.1038\/s41598-024-70331-8","article-title":"Association between dietary copper intake and constipation in US adults","volume":"14","author":"Du","year":"2024","journal-title":"Sci Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"4624","DOI":"10.1097\/JS9.0000000000001560","article-title":"Association between daily sitting time and kidney stones based on the National Health and nutrition examination survey (NHANES) 2007-2016: a cross-sectional study","volume":"110","author":"Li","year":"2024","journal-title":"Int J Surg"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e27764","DOI":"10.1016\/j.heliyon.2024.e27764","article-title":"Association between sitting time and urinary incontinence in the US population: data from the National Health and nutrition examination survey (NHANES) 2007 to 2018","volume":"10","author":"Di","year":"2024","journal-title":"Heliyon"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"949","DOI":"10.2147\/NSS.S469638","article-title":"Association of Sleep Duration with risk of all-cause and cause-specific mortality among American adults: a population-based cohort study","volume":"16","author":"Gu","year":"2024","journal-title":"Nat Sci Sleep"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.5664\/jcsm.10542","article-title":"Racial\/ethnic differences in the beneficial effect of social support on sleep duration","volume":"19","author":"Johnson","year":"2023","journal-title":"J Clin Sleep Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e002047","DOI":"10.1136\/bmjdrc-2020-002047","article-title":"Associations of impaired glucose tolerance and sleep disorders with mortality among the US general population","volume":"9","author":"Inoue","year":"2021","journal-title":"BMJ Open Diabetes Res Care"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2233712","DOI":"10.1080\/10641963.2023.2233712","article-title":"Association between composite dietary antioxidant index and hypertension: insights from NHANES","volume":"45","author":"Wu","year":"2023","journal-title":"Clin Exp Hypertens"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1111\/acer.14944","article-title":"Analysis of alcohol use, consumption of micronutrient and macronutrients, and liver health in the 2017-2018 National Health and nutrition examination survey","volume":"46","author":"Warner","year":"2022","journal-title":"Alcohol Clin Exp Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/1345071","article-title":"Association between the oxidative balance score and telomere length from the National Health and nutrition examination survey 1999-2002","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxidative Med Cell Longev"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.2147\/IJGM.S304706","article-title":"Dose-response Association of Waist-to-Height Ratio Plus BMI and risk of depression: evidence from the NHANES 05-16","volume":"14","author":"Ma","year":"2021","journal-title":"Int J Gen Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad220","article-title":"Rest-activity rhythms across the lifespan: cross-sectional findings from the US representative National Health and nutrition examination survey","volume":"46","author":"Wallace","year":"2023","journal-title":"Sleep"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.jad.2023.07.040","article-title":"Association of oxidative balance score with sleep quality: NHANES 2007-2014","volume":"339","author":"Lei","year":"2023","journal-title":"J Affect Disord"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e90193","DOI":"10.1371\/journal.pone.0090193","article-title":"Physical activity and constipation in Hong Kong adolescents","volume":"9","author":"Huang","year":"2014","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jshs.2023.02.002","article-title":"Associations of daily sedentary behavior, physical activity, and sleep with irritable bowel syndrome: a prospective analysis of 362,193 participants","volume":"13","author":"Gao","year":"2024","journal-title":"J Sport Health Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1249\/MSS.0000000000002822","article-title":"Effects of prolonged sitting with or without elastic garments on limb volume, arterial blood flow, and muscle oxygenation","volume":"54","author":"Kurosawa","year":"2022","journal-title":"Med Sci Sports Exerc"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"151844","DOI":"10.1016\/j.acthis.2022.151844","article-title":"Physical activity ameliorates the function of organs via adipose tissue in metabolic diseases","volume":"124","author":"Abedpoor","year":"2022","journal-title":"Acta Histochem"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"101700","DOI":"10.1016\/j.smrv.2022.101700","article-title":"Sleep, circadian biology and skeletal muscle interactions: implications for metabolic health","volume":"66","author":"Morrison","year":"2022","journal-title":"Sleep Med Rev"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e0176685","DOI":"10.1371\/journal.pone.0176685","article-title":"Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: the NEO study","volume":"12","author":"Lucassen","year":"2017","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1249\/MSS.0000000000002137","article-title":"Effects of sleep deprivation on acute skeletal muscle recovery after exercise","volume":"52","author":"D\u00e1ttilo","year":"2020","journal-title":"Med Sci Sports Exerc"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1113\/JP278828","article-title":"The effect of sleep restriction, with or without high-intensity interval exercise, on myofibrillar protein synthesis in healthy young men","volume":"598","author":"Saner","year":"2020","journal-title":"J Physiol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1097\/MIB.0000000000001265","article-title":"Bidirectional regulation of circadian disturbance and inflammation in inflammatory bowel disease","volume":"23","author":"Liu","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/MOG.0000000000000227","article-title":"Rhythm and bugs: circadian clocks, gut microbiota, and enteric infections","volume":"32","author":"Rosselot","year":"2016","journal-title":"Curr Opin Gastroenterol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/acer.12943","article-title":"The circadian clock mutation promotes intestinal Dysbiosis","volume":"40","author":"Voigt","year":"2016","journal-title":"Alcohol Clin Exp Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1053\/j.gastro.2007.03.059","article-title":"Obesity, inflammation, and insulin resistance","volume":"132","author":"Shoelson","year":"2007","journal-title":"Gastroenterology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e0123993","DOI":"10.1371\/journal.pone.0123993","article-title":"Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms","volume":"10","author":"Nagata","year":"2015","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1007\/s00192-024-05824-1","article-title":"Association of Constipation with modes of delivery: a retrospective questionnaire-based study","volume":"35","author":"Hierink","year":"2024","journal-title":"Int Urogynecol J"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1080\/07315724.2020.1727380","article-title":"Risk factors for constipation in adults: a cross-sectional study","volume":"39","author":"Yurtda\u015f","year":"2020","journal-title":"J Am Coll Nutr"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.3748\/wjg.v20.i10.2433","article-title":"Sex hormones in the modulation of irritable bowel syndrome","volume":"20","author":"Mulak","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183704","article-title":"Crosstalk between the gut microbiome and colonic motility in chronic constipation: potential mechanisms and microbiota modulation","volume":"14","author":"Pan","year":"2022","journal-title":"Nutrients"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"101173","DOI":"10.1016\/j.yfrne.2024.101173","article-title":"Gut feeling: exploring the intertwined trilateral nexus of gut microbiota, sex hormones, and mental health","volume":"76","author":"Leao","year":"2024","journal-title":"Front Neuroendocrinol"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2025.1548455\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T14:34:48Z","timestamp":1741876488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2025.1548455\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":42,"alternative-id":["10.3389\/fnut.2025.1548455"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2025.1548455","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]},"article-number":"1548455"}}