{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:51:16Z","timestamp":1775004676216,"version":"3.50.1"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperuricemia not only increases the risk of cardiovascular diseases such as dyslipidemia, hypertension, coronary artery disease, obesity, metabolic syndrome, and type-2 diabetes, but also severely impacts kidney function, potentially leading to acute kidney injury and chronic kidney disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study aims to investigate the health benefits of black chokeberry (<jats:italic>Aronia melanocarpa<\/jats:italic>) on hyperuricemic mice induced by oxonic acid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The experimental results showed that black chokeberry had no significant toxic or negative effects in mice. The measurement of uric acid (UA) indicated that black chokeberry suppressed the UA levels. Additionally, the xanthine oxidase activity in the high-dose group was significantly decreased, along with reductions in serum urea nitrogen and creatinine levels. Black chokeberry effectively increased the glutathione levels in hyperuricemic mice and reduced malondialdehyde levels, as well as significantly inhibiting adenosine deaminase activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Its efficacy is comparable to that of the marketed drug allopurinol, underscoring the potential of black chokeberry as a functional product for uric acid reduction.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1556527","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T14:32:26Z","timestamp":1747233146000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling the therapeutic benefits of black chokeberry (Aronia melanocarpa) in alleviating hyperuricemia in mice"],"prefix":"10.3389","volume":"12","author":[{"given":"Chin-Yuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeu-Ching","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"She-Ching","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"936717","DOI":"10.3389\/fpubh.2022.936717","article-title":"Prevalence of hyperuricemia and the population attributable fraction of modifiable risk factors: evidence from a general population cohort in China","volume":"10","author":"He","year":"2022","journal-title":"Front Public Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12882-022-02850-3","article-title":"Efficacy and safety of urate-lowering agents in asymptomatic hyperuricemia: systematic review and network meta-analysis of randomized controlled trials","volume":"23","author":"Sapankaew","year":"2022","journal-title":"BMC Nephrol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"105716","DOI":"10.1016\/j.jff.2023.105716","article-title":"Mangiferin reduces uric acid via regulation of amino acid and lipid metabolism","volume":"108","author":"Shi","year":"2023","journal-title":"J Funct Foods"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s11926-996-0029-z","article-title":"New developments in clinically relevant mechanisms and treatment of hyperuricemia","volume":"8","author":"Lee","year":"2006","journal-title":"Curr Rheumatol Rep"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1517\/13543784.2015.1051617","article-title":"Investigational drugs for hyperuricemia","volume":"24","author":"Shahid","year":"2015","journal-title":"Expert Opin Investig Drugs"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.tifs.2019.05.006","article-title":"Black chokeberry (Aronia melanocarpa) and its products as potential health-promoting factors\u2014an overview","volume":"89","author":"Sidor","year":"2019","journal-title":"Trends Food Sci Technol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/09540105.2018.1541967","article-title":"Aronia melanocarpa ameliorates gout and hyperuricemia in animal models","volume":"30","author":"Wang","year":"2018","journal-title":"Food Agric Immunol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.3390\/nu14132688","article-title":"Chokeberry (A. melanocarpa (Michx.) 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