{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:46:42Z","timestamp":1791859602680,"version":"4.3.4"},"reference-count":157,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    Marine polysaccharides, particularly those derived from red, brown, and green algae, have shown promising antiviral activity. Among them, sulfated polysaccharides are particularly notable due to their broad-spectrum antiviral properties. These include direct viral destruction, inhibition of virus adsorption, disruption of viral transcription and replication, and the stimulation of the host\u2019s antiviral immunity. With low toxicity, minimal drug resistance, and excellent biocompatibility, these polysaccharides represent promising candidates for the development of antiviral medications. For instance, carrageenan, a polysaccharide from red algae, and fucoidan, a polymer from brown algae, have both been proven to effectively inhibit viral infections. Sulfated polysaccharides from green algae, such as those found in\n                    <jats:italic>Ulva<\/jats:italic>\n                    species, also exhibit antiviral properties, including activity against the Japanese encephalitis virus. These polysaccharides function by blocking the attachment of viruses to host cells or interfering with various stages of the viral life cycle. Moreover, marine polysaccharides have been shown to enhance host immune responses, thereby aiding in viral clearance. Although these findings highlight the antiviral potential of marine polysaccharides, most studies have been conducted\n                    <jats:italic>in vitro<\/jats:italic>\n                    or in animal models. Further clinical trials are necessary to validate their effectiveness and safety for therapeutic use.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2025.1561119","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T01:32:55Z","timestamp":1742952775000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Recent advances of edible marine algae-derived sulfated polysaccharides in antiviral treatments: challenges vs. opportunities"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiaoying","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhen","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4695","DOI":"10.3390\/molecules29194695","article-title":"Bioactive potential of algae and algae-derived compounds: focus on anti-inflammatory, antimicrobial, and antioxidant effects","volume":"29","author":"Matin","year":"2024","journal-title":"Molecules"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2991\/efood.k.190822.001","article-title":"miRNAs as regulators of antidiabetic effects of fucoidans","volume":"1","author":"Zhao","year":"2019","journal-title":"eFood"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/fft2.13","article-title":"The algal polysaccharide ulvan suppresses growth of hepatoma cells","volume":"1","author":"Zhao","year":"2020","journal-title":"Food Front"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"105310","DOI":"10.1016\/j.fbio.2024.105310","article-title":"Green algal polysaccharides and derivatives as potential therapeutics for metabolic diseases","volume":"62","author":"Qiu","year":"2024","journal-title":"Food Biosci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.fct.2009.03.016","article-title":"In vitro cancer chemopreventive properties of polysaccharide extract from the brown alga, Sargassum latifolium","volume":"47","author":"Gamal-Eldeen","year":"2009","journal-title":"Food Chem Toxicol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.fct.2009.09.036","article-title":"In vitro antioxidant and in vivo anti-inflammatory potential of crude polysaccharide from Turbinaria ornata (marine brown alga)","volume":"48","author":"Ananthi","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.antiviral.2009.06.007","article-title":"Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus","volume":"83","author":"Harden","year":"2009","journal-title":"Antivir Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.fct.2008.11.012","article-title":"Anti-asthmatic effect of marine red alga (Laurencia undulata) polyphenolic extracts in a murine model of asthma","volume":"47","author":"Jung","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.bbagen.2009.03.011","article-title":"Marine pharmacology in 2005\u20136: marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; 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