{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:30Z","timestamp":1753891950759,"version":"3.41.2"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Prior research has established a correlation between dietary micronutrient intake and the risk of developing constipation. However, the potential link between vitamin B intake and constipation has yet to be fully explored. This study sought to assess the association between chronic constipation and dietary vitamin B intake based on National Health and Nutrition Examination Survey (NHANES) data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study employed NHANES data collected between 2005 and 2010, including a total of 13,885 participants 20\u202f+\u202fyears of age. Dietary intake of vitamins B1, B2, niacin, B6, folic acid, choline, and B12 was assessed using the first 24-h dietary recall interview. Constipation was defined based on the Bristol Stool Form Scale (BSFS). A weighted logistic regression model and restricted cubic spline (RCS) analysis were utilized to adjust for demographic and lifestyle-related variables and probe the relationship between B vitamin intake and constipation. Statistical significance was set at a two-tailed <jats:italic>p<\/jats:italic>-value &amp;lt; 0.05. Confidence intervals (95% CIs) were calculated using weighted logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis revealed a nonlinear inverse correlation between dietary intake of all examined B vitamins and constipation risk. In particular, a significant reduction in constipation odds was observed in the highest intake quartiles of niacin (OR\u202f=\u202f0.76, 95% CI: 0.59\u20130.99, p for trend\u202f=\u202f0.003), folate (OR\u202f=\u202f0.61, 95% CI: 0.48\u20130.79, p for trend &amp;lt; 0.001), and choline (OR\u202f=\u202f0.77, 95% CI: 0.60\u20131.00, p for trend\u202f=\u202f0.05) when using a model that was fully adjusted. Subgroup analyses further indicated that alcohol consumption significantly modified the relationship between folate (p for interaction\u202f=\u202f0.003), vitamin B1 (p for interaction\u202f=\u202f0.004), niacin (p for interaction\u202f=\u202f0.04), choline (p for interaction\u202f=\u202f0.02), and constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased dietary intake of B vitamins may contribute to a reduced risk of constipation, particularly among specific population subgroups. These results offer additional support for the potential role of dietary modifications in promoting gut health.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1594644","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T04:12:35Z","timestamp":1748491955000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the link between the dietary intake of vitamin B and constipation: a population-based study"],"prefix":"10.3389","volume":"12","author":[{"given":"Wenyuan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaojian","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shicheng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/S2468-1253(19)30199-2","article-title":"Chronic constipation: new insights, better outcomes?","volume":"4","author":"Schiller","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1016\/j.mayocp.2019.01.031","article-title":"Chronic constipation","volume":"94","author":"Bharucha","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome foundation global study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1053\/j.gastro.2012.10.028","article-title":"American Gastroenterological Association technical review on constipation","volume":"144","author":"Bharucha","year":"2013","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"17095","DOI":"10.1038\/nrdp.2017.95","article-title":"Chronic constipation","volume":"3","author":"Camilleri","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3390\/nu14010122","article-title":"Association between dietary factors and constipation in adults living in Luxembourg and taking part in the ORISCAV-LUX 2 survey","volume":"14","author":"Rollet","year":"2021","journal-title":"Nutrients"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1007\/s12011-020-02451-x","article-title":"Association between selenium intake with chronic constipation and chronic diarrhea in adults: findings from the National Health and nutrition examination survey","volume":"199","author":"Wang","year":"2021","journal-title":"Biol Trace Elem Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1111\/nmo.12630","article-title":"Association of high dietary saturated fat intake and uncontrolled diabetes with constipation: evidence from the National Health and nutrition examination survey","volume":"27","author":"Taba Taba Vakili","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1186\/s12889-022-14360-w","article-title":"Association between overall dietary quality and constipation in American adults: a cross-sectional study","volume":"22","author":"Liu","year":"2022","journal-title":"BMC Public Health"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.7812\/TPP\/21.204","article-title":"B vitamins: functions and uses in medicine","volume":"26","author":"Hanna","year":"2022","journal-title":"Perm J"},{"volume-title":"The National Academies Collection: Reports funded by National Institutes of Health. 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