{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:19:55Z","timestamp":1784639995289,"version":"3.55.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Celery is commonly used as a diet intervention for hypertension, hyperglycemia, and hyperlipidemia. However, its precise therapeutic efficacy remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to comprehensively evaluate the efficacy of celery preparations in regulating blood pressure, blood glucose, and blood lipids profiles in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted in PubMed, Web of Science, EMBASE, Scopus, Cochrane Library, <jats:ext-link>Clinicaltrials.gov<\/jats:ext-link>, China Biology Medicine disc, and China National Knowledge Infrastructure. Randomized controlled trials of celery were included. Data were analyzed using either a random-effects model or a fixed-effects model, depending on heterogeneity, and were presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs). All eligible studies were evaluated in terms of study characteristics, risk of bias, me-ta-analysis, sensitivity analysis, meta-regression, and publication bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our meta-analysis included ten randomized controlled studies with a total of 511 participants. The results demonstrated significant therapeutic effects of celery on systolic blood pressure (SMD: \u22121.0; 95% CI: \u22121.85 to \u22120.14), diastolic blood pressure (SMD: \u22120.93; 95% CI: \u22121.54 to \u22120.33), fasting plasma glucose (SMD: \u22120.80; 95% CI: \u22121.58 to \u22120.01), and triglyceride (SMD: \u22121.18; 95% CI: \u22121.45 to \u22120.91). However, no overall effects were observed on total cholesterol, low-density lipoprotein, or high-density lipo-protein. Subgroup analysis revealed that celery seeds or celery preparations exceeding 1,000 mg\/day were more effective than other parts of celery. Additionally, no significant difference in adverse events between celery and placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta-analysis demonstrated that Celery preparations significantly improve hypertension, hyperglycemia, and hyperlipidemia, with a favorable safety profile. Celery seeds or celery preparations exceeding 1,000 mg\/day will have better effect. These findings suggest that celery performs well as a potential dietary supplement for reducing hypertension, hyperglycemia, and hyperlipidemia. However, the substantial heterogeneity observed for most outcomes and limited sample sizes warrant further high-quality clinical trials with longer follow-up periods to confirm these effects and establish optimal dosing regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD42025631143<\/jats:ext-link>, PROSPERO: CRD42025631143.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1597680","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T04:10:33Z","timestamp":1753157433000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of celery (Apium graveolens) on blood pressure, glycemic and lipid profile in adults: a systematic review and meta-analysis of randomized controlled 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