{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:28:10Z","timestamp":1784600890437,"version":"3.55.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>As an important part of the limbic system of the forebrain, the bed nucleus of the stria terminalis (BNST) plays a key role in stress response, emotion regulation, and motivational behavior. Recent studies have demonstrated that BNST plays a crucial role in the pathological process of appetite regulation, food selection, and eating disorders by integrating metabolic signals, reward feedback, and stress input. This article systematically reviews the anatomical subdivision, neural loop characteristics, and multimodal mechanisms of the BNST in food intake regulation; discusses its association with obesity, anorexia nervosa, and other diseases; and explores potential therapeutic strategies targeting the BNST.<\/jats:p>","DOI":"10.3389\/fnut.2025.1598703","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T13:11:39Z","timestamp":1757077899000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of the bed nucleus of the stria terminalis in feeding"],"prefix":"10.3389","volume":"12","author":[{"given":"Keyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/npp.2009.109","article-title":"Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety","volume":"35","author":"Davis","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s11065-018-9383-7","article-title":"Distinct activity patterns of the human bed nucleus of the Stria Terminalis and amygdala during fear learning","volume":"29","author":"Luyck","year":"2019","journal-title":"Neuropsychol Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/npp.2015.178","article-title":"Stress modulation of opposing circuits in the bed nucleus of the Stria Terminalis","volume":"41","author":"Daniel","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/mp.2016.1","article-title":"Overshadowed by the amygdala: the bed nucleus of the Stria Terminalis emerges as key to psychiatric disorders","volume":"21","author":"Lebow","year":"2016","journal-title":"Mol Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1101\/lm.044206.116","article-title":"Role of the bed nucleus of the Stria Terminalis in aversive learning and memory","volume":"24","author":"Goode","year":"2017","journal-title":"Learn Mem"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"8038","DOI":"10.1523\/jneurosci.0856-16.2016","article-title":"Functional heterogeneity in the bed nucleus of the Stria Terminalis","volume":"36","author":"Gungor","year":"2016","journal-title":"J Neurosci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14348\/molcells.2015.2261","article-title":"Neuropeptide regulation of signaling and behavior in the BNST","volume":"38","author":"Kash","year":"2015","journal-title":"Mol Cells"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neuropharm.2017.03.028","article-title":"The bed nucleus of the Stria Terminalis in drug-associated behavior and affect: a circuit-based perspective","volume":"122","author":"Vranjkovic","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"20150109","DOI":"10.1098\/rstb.2015.0109","article-title":"Genetic dissection of neural circuits underlying sexually dimorphic social Behaviours","volume":"371","author":"Bayless","year":"2016","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nrn.2017.71","article-title":"Neural circuits underlying thirst and fluid homeostasis","volume":"18","author":"Zimmerman","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2174\/1570159x11311020002","article-title":"Mechanisms in the bed nucleus of the Stria Terminalis involved in control of autonomic and neuroendocrine functions: a review","volume":"11","author":"Crestani","year":"2013","journal-title":"Curr Neuropharmacol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.psyneuen.2017.12.005","article-title":"Anteroventral bed nuclei of the Stria Terminalis Neurocircuitry: towards an integration of Hpa Axis modulation with coping behaviors - 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