{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:06:58Z","timestamp":1790856418310,"version":"4.1.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"\n Background<\/jats:title>\n Coenzyme Q10 (CoQ-10) plays a vital role in cellular energy production and protection against oxidative stress. However, its absorption from orally administered forms is limited due to its poor water solubility and relatively large molecular weight. While co-ingesting CoQ-10 with a fatty meal can enhance absorption, this approach is not always practical. The aim of this study was to evaluate whether a liposomal formulation of CoQ-10 could improve its absorption compared with standard CoQ-10 without the need for the concurrent consumption of fatty foods.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In a randomized, double-blind, placebo-controlled, crossover study design, 7 men and 11 women (\n n<\/jats:italic>\n \u202f=\u202f18; age: 33.5\u202f\u00b1\u202f6.4\u202fyears, height: 171.2\u202f\u00b1\u202f8.1\u202fcm, weight: 65.6\u202f\u00b1\u202f8.8\u202fkg) ingested a single dose of placebo (PLA), 100\u202fmg of unformulated CoQ-10, or 100\u202fmg of liposomal CoQ-10 (Lipo CoQ-10, LipoVantage\u00ae, Specnova, LLC, Tyson Corner, VA, USA). Venous blood samples were collected at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24\u202fh after ingestion and analyzed for plasma CoQ-10 concentrations.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n CoQ-10and Lipo CoQ-10 demonstrated significantly greater Cmax and AUC0-24 compared with placebo (\n p<\/jats:italic>\n \u202f&lt;\u202f0.001). Additionally, Lipo CoQ-10 had significantly higher Cmax (+31.3%,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001) and AUC0-24 (+22.6%,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001) values as compared with CoQ-10. CoQ-10 formulations were well-tolerated, with no significant changes in safety markers (blood pressure, renal function, liver enzymes, and lipid profile;\n p<\/jats:italic>\n \u202f&gt;\u202f0.05), indicating a favorable safety profile.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Liposomal delivery significantly enhances CoQ-10 absorption.<\/jats:p>\n <\/jats:sec>\n \n Clinical trial registration<\/jats:title>\n \n https:\/\/www.ctri.nic.in<\/jats:uri>\n identifier CTRI\/2024\/04\/066483.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fnut.2025.1605033","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T13:30:04Z","timestamp":1758115804000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of liposomal delivery on coenzyme Q10 absorption: a double-blind, placebo-controlled, randomized trial"],"prefix":"10.3389","volume":"12","author":[{"given":"Ralf","family":"J\u00e4ger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Purpura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Godavarthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil Ibrahim","family":"Ceylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian T.","family":"Balcombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambrish","family":"Chandrappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant M.","family":"Tinsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref1","volume-title":"Coenzyme Q10: StatPearls","author":"Sood","year":"2025"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.14797\/mdcj-15-3-185","article-title":"Coenzyme Q10","volume":"15","author":"Raizner","year":"2019","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3390\/antiox10020236","article-title":"Coenzyme Q10 analogues: benefits and challenges for therapeutics","volume":"10","author":"Su\u00e1rez-Rivero","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"8432","DOI":"10.3390\/ijms21228432","article-title":"Coenzyme Q10: novel formulations and medical 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formulations","volume-title":"Integr Med (Encinitas)","author":"Judy","year":"2022"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1159\/000129661","article-title":"Relative bioavailability of two forms of a novel water-soluble coenzyme Q10","volume":"52","author":"Zmitek","year":"2008","journal-title":"Ann Nutr Metab"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1080\/10715760600617843","article-title":"Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics","volume":"40","author":"Bhagavan","year":"2006","journal-title":"Free Radic Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3390\/nu11030527","article-title":"Bioavailability and sustained plasma concentrations of CoQ10 in healthy volunteers by a novel Oral timed-release 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trials","volume":"119","author":"Fan","year":"2017","journal-title":"Pharmacol Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/biof.5520320124","article-title":"Safety assessment of coenzyme Q10 (CoQ10)","volume":"32","author":"Hidaka","year":"2008","journal-title":"Biofactors"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"12:1\u20139","DOI":"10.1186\/1475-2891-12-142","article-title":"Effects of coenzyme Q10 supplementation (300 mg\/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial","volume":"12","author":"Lee","year":"2013","journal-title":"Nutr J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s40292-018-0247-2","article-title":"The effects of coenzyme Q10 supplementation on blood pressures among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled 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from a subgroup analysis of a prospective randomised double-blind placebo-controlled trial","volume":"12","author":"Alehagen","year":"2020","journal-title":"Nutrients"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.1017\/jns.2021.106","article-title":"Women have higher levels of CoQ10 than men when supplemented with a single dose of CoQ10 with monoglycerides omega-3 or rice oil and followed for 48 h: a crossover randomised triple blind controlled study","volume":"11","author":"Beaulieu","year":"2022","journal-title":"J Nutr Sci"}],"container-title":["Frontiers in 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