{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:09:03Z","timestamp":1792710543991,"version":"4.5.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008866","name":"Changhai Hospital of Shanghai","doi-asserted-by":"publisher","award":["2019YXK014"],"award-info":[{"award-number":["2019YXK014"]}],"id":[{"id":"10.13039\/501100008866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008866","name":"Changhai Hospital of Shanghai","doi-asserted-by":"publisher","award":["22QA1411400"],"award-info":[{"award-number":["22QA1411400"]}],"id":[{"id":"10.13039\/501100008866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum 25 (OH) D levels are associated with various diseases, including cancers, but inconsistencies exist for female-specific malignancies. This study is aimed to explore the real relationship between serum 25 (OH) D levels and incidence rates of female specific cancers in premenopausal women by a large-scale prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>We analyzed data from 51,286 UK Biobank participants using Cox regression models to explore associations. Subgroup analyses were based on vitamin D supplementation, alcohol, smoking, BMI, diabetes, sleep, and outdoor exposure. Categorical variables were described by frequencies and compared with chi-squared tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow-up of 13.8\u202fyears, all cancer incidence was 5.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f2,614), with ovarian cancer at 0.3% (n\u202f=\u202f176), breast cancer at 4.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f2,232), and uterine body cancer at 0.5% (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f235). Low serum 25 (OH) D (50\u202fnmol\/L) was linked to increased risks of ovarian (HR: 1.457, 95% CI: 1.047\u20132.027) and uterine body cancer (HR: 1.372, 95% CI: 1.023\u20131.841). Each 10\u202fnmol\/L increase in 25 (OH) D reduced ovarian cancer risk (HR: 0.904, 95% CI: 0.835\u20130.979). Alcohol use and sleep &amp;lt;6\u202fh were risk factors for ovarian and uterine cancer in those with low 25 (OH) D levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maintaining adequate serum 25 (OH) D levels is essential for overall health, reducing the risk of ovarian cancer, and potentially lowering susceptibility to uterine corpus cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2025.1617565","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T14:54:06Z","timestamp":1757948046000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum 25 (OH) D levels and risk of female-specific cancer in premenopausal women: a prospective study"],"prefix":"10.3389","volume":"12","author":[{"given":"Yue","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jsbmb.2017.01.021","article-title":"Vitamin 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