{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T04:40:17Z","timestamp":1756183217255,"version":"3.44.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the association between serum amino acid changes and alopecia in patients with obesity before and after bariatric surgery, and identify risk factors for postoperative alopecia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study (ChiCTR2300074104) included patients with obesity undergoing laparoscopic sleeve gastrectomy (LSG), categorized into non-mild alopecia (NM group, <jats:italic>n<\/jats:italic>\u202f=\u202f24) and moderate\u2013severe alopecia (MS group, <jats:italic>n<\/jats:italic>\u202f=\u202f43) groups. Clinical data and serum amino acid concentrations were analyzed to: (1) compare preoperative and postoperative amino acid profiles; (2) evaluate amino acid differences between groups at various timepoints and correlate with alopecia severity; (3) perform logistic regression to identify alopecia risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 67 patients analyzed, LSG significantly decreased serum concentrations of arginine, alanine, threonine, glutamic acid, branched-chain amino acids (valine, isoleucine, leucine), and aromatic amino acids (tyrosine, phenylalanine, tryptophan) (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05), while serine and glycine increased (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05). At 3\u202fmonths postoperatively, leucine levels were higher in the MS group compared to the NM group. Spearman\u2019s correlation analysis revealed threonine, <jats:italic>\u03b3<\/jats:italic>-aminobutyric acid, and leucine levels were associated with alopecia severity (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05). Logistic regression identified serum leucine as an independent risk factor for postoperative alopecia (OR\u202f=\u202f1.119, 95% CI 1.006-1.245, <jats:italic>p<\/jats:italic>\u202f=\u202f0.038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LSG surgery alters the serum amino acid profile in patients with obesity, and serum leucine concentration at 3\u202fmonths postoperatively is an influential factor in postoperative alopecia.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1618630","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T04:12:48Z","timestamp":1756181568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study"],"prefix":"10.3389","volume":"12","author":[{"given":"Tingwen","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehui","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojie","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref1","volume-title":"Obesity and overweight","year":"2016"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/bs.acc.2020.06.004","article-title":"Cytokines and the immune response in obesity-related disorders","volume":"101","author":"Moghbeli","year":"2021","journal-title":"Adv Clin Chem"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1200\/JCO.2016.67.4283","article-title":"Obesity and cancer mechanisms: tumor microenvironment and inflammation","volume":"34","author":"Iyengar","year":"2016","journal-title":"J Clin Oncol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"O1","DOI":"10.1002\/oby.22719","article-title":"Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures - 2019 update: cosponsored by American Association of Clinical Endocrinologists\/American College of Endocrinology, the Obesity Society, American Society for Metabolic and Bariatric Surgery, obesity medicine association, and American Society of Anesthesiologists","volume":"28","author":"Mechanick","year":"2020","journal-title":"Obesity"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/joim.12012","article-title":"Review of the key results from the Swedish obese subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery","volume":"273","author":"Sj\u00f6str\u00f6m","year":"2013","journal-title":"J Intern Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/j.soard.2022.05.007","article-title":"Effect of bariatric surgery on long-term cardiovascular outcomes: a systematic review and meta-analysis of population-based cohort studies","volume":"18","author":"Tang","year":"2022","journal-title":"Surg Obes Relat Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1007\/s11695-012-0591-6","article-title":"Laparoscopic sleeve gastrectomy as a stand-alone procedure for morbid obesity: report of 1,000 cases and 3-year follow-up","volume":"22","author":"Boza","year":"2012","journal-title":"Obes Surg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1007\/s11695-020-04488-2","article-title":"In terms of nutrition, the Most suitable method for bariatric surgery: laparoscopic sleeve gastrectomy or roux-en-Y gastric bypass? 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