{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:29Z","timestamp":1787026949376,"version":"build-2736575974"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Integrating ginger, which is effective in preventing postoperative nausea and vomiting (PONV), into perioperative nutritional strategies for neurosurgical patients may enhance postoperative recovery. In this study, we evaluated whether adding standardized ginger extract to a preoperative carbohydrate drink improves postoperative outcomes in patients undergoing elective neuro-oncologic craniotomy with enhanced recovery after surgery (ERAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, double-blind, randomized controlled trial enrolled adult patients scheduled for elective neuro-oncologic craniotomy. Participants were randomly assigned to receive either a carbohydrate drink containing standardized ginger extract (ginger group) or an identical carbohydrate drink without it (control group) 2\u202fh before anesthesia induction. All patients received co-treatment following the institutional ERAS protocol. The primary outcomes included the incidence of PONV, nausea severity, vomiting episodes, and rescue antiemetic use within 48\u202fh. Secondary outcomes assessed patient well-being and metabolic and inflammatory responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 48 patients were enrolled. The incidence of PONV did not significantly decrease (25% vs. 37.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.534), but vomiting episodes were significantly reduced (6 vs. 23 episodes;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.003). Moreover, Poisson regression confirmed a lower incidence rate of vomiting in the ginger group than on the control group [incidence rate ratio (IRR): 0.32, 95% CI 0.16\u20130.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.017]. No significant differences were found in metabolic markers, inflammatory responses, or well-being scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Preoperative administration of ginger-enriched carbohydrate drinks effectively reduced the number of vomiting episodes following elective craniotomy. Although other clinical and laboratory outcomes remained unchanged, this nutritional strategy may be beneficial for inclusion in ERAS protocols for elective craniotomy patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>www.ThaiClinicalTrial.org<\/jats:uri>\n                      , identifier TCTR20220124002.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2025.1624176","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T13:52:56Z","timestamp":1759499576000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Does adding ginger extract to a preoperative carbohydrate drink improve outcomes in enhanced recovery after elective neuro-oncologic craniotomy? A randomized controlled trial"],"prefix":"10.3389","volume":"12","author":[{"given":"Anukoon","family":"Kaewborisutsakul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanatthee","family":"Kitsiripant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitong","family":"Churuangsuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panupong","family":"Puttarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onnicha","family":"Suntornlohanakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanin","family":"Khanungwanitkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athithan","family":"Rattanaburi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supattra","family":"Uppanisakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanisorn","family":"Sungkaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin","family":"Taweesomboonyat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thara","family":"Tunthanathip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thakul","family":"Oearsakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakchai","family":"Sae-Heng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1001\/jamasurg.2016.4952","article-title":"Enhanced recovery after surgery: a review","volume":"152","author":"Ljungqvist","year":"2017","journal-title":"JAMA Surg"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0000000000001011","article-title":"Enhanced recovery after craniotomy: global practices, challenges, and perspectives","author":"Di Donato","year":"2024","journal-title":"J Neurosurg Anesthesiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/ANA.0000000000000967","article-title":"Enhanced recovery after surgery for craniotomies: a systematic review and meta-analysis","volume":"37","author":"Kim","year":"2025","journal-title":"J Neurosurg Anesthesiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.3171\/2020.10.JNS203160","article-title":"Enhanced recovery after surgery strategies for elective craniotomy: a systematic review","volume":"135","author":"Stumpo","year":"2021","journal-title":"J Neurosurg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4745","DOI":"10.1016\/j.clnu.2021.03.031","article-title":"ESPEN practical guideline: clinical nutrition in surgery","volume":"40","author":"Weimann","year":"2021","journal-title":"Clin Nutr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3171\/2023.9.FOCUS23316","article-title":"Effect of the enhanced recovery protocol in patients with brain tumors undergoing elective craniotomies: a systematic review and meta-analysis","volume":"55","author":"Supbumrung","year":"2023","journal-title":"Neurosurg Focus"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00268-018-4844-y","article-title":"Guidelines for perioperative care in elective colorectal surgery: enhanced recovery after surgery (ERAS\u00ae) society recommendations: 2018","volume":"43","author":"Gustafsson","year":"2019","journal-title":"World J Surg"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.1111\/jocn.14919","article-title":"Are carbohydrate drinks more effective than preoperative fasting: a systematic review of randomised controlled trials","volume":"28","author":"Noba","year":"2019","journal-title":"J Clin Nurs"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"CD009161","DOI":"10.1002\/14651858.CD009161.pub2","article-title":"Preoperative carbohydrate treatment for enhancing recovery after elective surgery","volume":"2014","author":"Smith","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1007\/s00464-015-4071-7","article-title":"Effects of preoperative carbohydrates drinks on immediate postoperative outcome after day care laparoscopic cholecystectomy","volume":"29","author":"Singh","year":"2015","journal-title":"Surg Endosc"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/ncp.10427","article-title":"How sweet is this? 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