{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:53:00Z","timestamp":1789728780611,"version":"4.0.1"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Early postnatal undernutrition, leading to impaired growth and low body weight, has been associated with enduring metabolic alterations that may persist into adulthood. We proposed that plant-based \u03c9-3 fatty acids, as in maternal supplementation, attenuate metabolic alterations induced by postnatal dietary restriction, such as glucose disturbances and oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To test this, we investigated the effects of maternal supplementation with two distinct doses of Chia Oil (ChO) (2.5 or 5 g\/kg body mass) on metabolic parameters in BALB\/c mice subjected to postnatal undernutrition. The undernutrition model was created by increasing the litter size to 15\u201316 pups, forming the undernutrition (UN) group. These UN groups received maternal ChO supplementation at 2.5 g\/kg or 5 g\/kg b.m., labeled as UN2.5 and UN5, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By day 21, the UN5 group showed less weight gain compared to the UN2.5 group. At 120 days, glucose tolerance tests revealed a lower area under the curve in both supplemented groups compared to the UN animals. A maternal dose of 5 g\/kg b.m. of ChO was linked to more favorable oxidative stress markers, suggesting this effect is not due to changes in antioxidant enzymes like superoxide dismutase and catalase, which remained stable in the liver tissue in this model. This dose provided a slight benefit in reducing metabolic changes, with the UN5 group showing lower total hepatic lipid levels. Additionally, histopathological analysis of the tissue revealed no alterations in the experimental groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These observations suggest a protective role of maternal ChO supplementation at a dose of 5 g\/kg b.w. against metabolic impairments induced by postnatal undernutrition.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1636396","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T04:14:42Z","timestamp":1755663282000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal supplementation with chia oil attenuates hepatic metabolic disturbances in mice subjected to postnatal undernutrition"],"prefix":"10.3389","volume":"12","author":[{"given":"Est\u00e9fany Ribeiro","family":"Le\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Konig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Melo","family":"Silva Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo de Sousa","family":"Candido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Suzan","family":"Varaschin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Cristina Jardim P\u00f4rto","family":"Pimenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Coelho de","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1651-2227.1997.tb18351.x","article-title":"The fetal origins of coronary heart disease","volume":"86","author":"Barker","year":"1997","journal-title":"Acta Paediatr."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ajhb.20590","article-title":"Early life events and their consequences for later disease: a life history and evolutionary perspective","volume":"19","author":"Gluckman","year":"2007","journal-title":"Am J Hum Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e0121954","DOI":"10.1371\/journal.pone.0121954","article-title":"Perinatal overnutrition exacerbates adipose tissue inflammation caused by high-fat feeding in C57BL\/6J mice","volume":"10","author":"Kayser","year":"2015","journal-title":"PLoS ONE."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e13482","DOI":"10.1111\/eci.13482","article-title":"Lactation as a programming window for metabolic syndrome","volume":"51","author":"Pic\u00f3","year":"2021","journal-title":"Eur J Clin Invest."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yhbeh.2020.104690","article-title":"Neonatal nutritional programming induces gliosis and alters the expression of T-cell protein tyrosine phosphatase and connexins in male rats","volume":"120","author":"Debarba","year":"2020","journal-title":"Horm Behav"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.psyneuen.2011.01.006","article-title":"Anxiety and hypothalamic-pituitary-adrenal axis responses to psychological stress are attenuated in male rats made lean by large litter rearing","volume":"36","author":"Bulfin","year":"2011","journal-title":"Psychoneuroendocrinology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3945\/jn.112.172825","article-title":"Postnatal overfeeding in rodents by litter size reduction induces major short- and long-term","volume":"143","author":"Habbout","year":"2013","journal-title":"J Nutr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1113\/JP277637","article-title":"Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity","volume":"597","author":"Ferguson","year":"2019","journal-title":"J Physiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"112793","DOI":"10.1016\/j.physbeh.2019.112793","article-title":"Perinatal over- and underfeeding affect hypothalamic leptin and ghrelin neuroendocrine responses in adult rats","volume":"215","author":"Marangon","year":"2020","journal-title":"Physiol Behav."},{"key":"B10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neulet.2012.07.054","article-title":"Ximenes-da-silva A. 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