{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:15:43Z","timestamp":1760141743677,"version":"build-2065373602"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Vitamin D deficiency has garnered increasing attention as a potential risk factor for thyroid dysfunction and oncological progression. This study was designed to investigate the relationship between preoperative vitamin D status and postoperative complications in patients undergoing thyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study investigated the association between preoperative vitamin D status and postoperative outcomes in a cohort of 120 patients following thyroidectomy for benign or malignant thyroid disease at Shengjing Hospital, China (2020\u20132022). Participants were stratified into three groups based on serum 25-hydroxyvitamin D [25(OH)D] concentrations: deficient (&amp;lt;20\u202fng\/mL), insufficient (20\u201330\u202fng\/mL), and sufficient (&amp;gt;30\u202fng\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitamin D-deficient patients exhibited higher preoperative TSH levels (4.8\u202f\u00b1\u202f1.6 vs. 2.7\u202f\u00b1\u202f0.9\u202fmIU\/L, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001), lower free T3\/T4, and reduced serum calcium (8.5\u202f\u00b1\u202f0.6 vs. 9.1\u202f\u00b1\u202f0.5\u202fmg\/dL, <jats:italic>p<\/jats:italic>\u202f=\u202f0.004) compared to sufficient patients. After operation, vitamin D deficiency was associated with increased odds of hypocalcemia (OR: 4.17, 95%CI: 1.31\u201313.35, <jats:italic>p<\/jats:italic>\u202f=\u202f0.01) and hypothyroidism (OR\u202f=\u202f2.91, 95%CI: 1.14\u20137.42, <jats:italic>p<\/jats:italic>\u202f=\u202f0.02) after adjustment for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this study indicate that preoperative screening for, and subsequent correction of, vitamin D deficiency could lead to improved postoperative recovery and a reduction in complications among patients undergoing thyroidectomy. Further research is needed to establish causal relationships and explore the underlying mechanisms linking vitamin D status to thyroid function and surgical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnut.2025.1645851","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T04:19:58Z","timestamp":1760069998000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D deficiency as a potential risk factor for thyroid cancer: a clinical perspective"],"prefix":"10.3389","volume":"12","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanjia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global 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