{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:08:02Z","timestamp":1767204482111,"version":"build-2238731810"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To observe the effects of iron supplementation on a physiological pregnancy and on pregnancy following iron deficiency anemia (IDA) caused by low-iron diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Physiological pregnancy anemia and IDA-induced pregnancy rat models were established, and the effects of preventive iron supplementation with ferrous succinate tablets (Sulifei, SLF) and polysaccharide\u2013iron complex (Niferex, LFN) on pregnancy ability, embryonic development, anemia indicators, and iron content and metabolic indicators were observed in the model rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Anemia markers and body iron content were decreased in physiological pregnancy rat model, accompanied by abnormal oxidative stress and iron metabolism. In post-IDA gestational rat model, these markers were even more severely aggravated. SLF and LFN intervention improved body iron content, oxidative stress, and iron metabolism-related markers in physiological pregnant rats, but did not improve anemia-related markers. After 6\u202fweeks of pretreatment with SLF and LFN, some reproductive toxicity effects were observed. SLF and LFN intervention in post-IDA gestational rat model improved anemia markers, body iron content, and iron metabolism-related markers. There were no significant differences in reproductive parameters between the two groups. Fetal weight and the average crown\u2013rump length per litter increased in the LFN group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post-IDA gestation further exacerbates iron deficiency anemia. Prophylactic iron supplementation can significantly improve physiological iron deficiency and iron metabolism during pregnancy but cannot improve iron deficiency anemia. In contrast, iron supplementation can significantly improve iron deficiency anemia in post-IDA gestation. To prevent or treat pregnancy complicated by IDA, iron supplementation is recommended either before the onset of IDA or after pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2025.1650536","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T14:41:41Z","timestamp":1757688101000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential effects of prophylactic iron supplementation on physiological gestational anemia and post-IDA gestational anemia: a study based on a rat model"],"prefix":"10.3389","volume":"12","author":[{"given":"Zelin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3390\/nu16070994","article-title":"Exploring gene -diet interactions for mother-child health: a systematic review of epidemiological studies","volume":"16","author":"Favara","year":"2024","journal-title":"Nutrients"},{"key":"ref2","year":""},{"key":"ref3","year":""},{"key":"ref4","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3967\/bes2024.022","article-title":"Establishment of an iron deficiency model by iron depletion in pregnant rats","volume":"37","author":"Chen","year":"2024","journal-title":"Biomed Environ Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3390\/nu12020447","article-title":"Iron deficiency and Iron deficiency Anemia: implications and impact in pregnancy, fetal development, and early childhood parameters","volume":"12","author":"Means","year":"2020","journal-title":"Nutrients"},{"key":"ref6","volume-title":"Proper maternal nutrition during pregnancy planning and pregnancy: A healthy start in life","author":"Meija","year":"2017"},{"key":"ref7","volume-title":"Diagnostik und Therapie der Eisenmange lan\u00e4mie inder Schwangerschaft und postpartal\u2013 Schweizerische Gesellschaft f\u00fcr Gyn\u00e4kologie und Geburtshilfe. 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