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As plant-derived weak estrogen analogs, phytoestrogens demonstrate menopause-related protective potential in preclinical studies by selectively activating ER\u03b1, ER\u03b2, and GPER receptor targets to modulate downstream signaling pathways. Current clinical trials indicate their value as an alternative strategy to menopausal hormone therapy (MHT, previously referred to as HRT) for managing menopause-related disorders. Although heterogeneity exists across study outcomes, specific formulations have shown clear efficacy. 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