{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T05:21:27Z","timestamp":1763529687548,"version":"3.45.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Nowadays it is well known that obesity and vitamin D deficiency are closely linked. In this view, this study aimed to assess the effects of two different Vitamin D formulations, combined with a Mediterranean hypocaloric diet (MHD) on 25(OH)D concentration, weight loss and visceral adiposity in subjects with obesity and vitamin D insufficiency\/deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-four patients with obesity were retrospectively selected and divided into three groups according to the type of treatment received: MHD alone (C group), MHD\u202f+\u202fcholecalciferol (D group), and MHD\u202f+\u202fcalcifediol (N group). 25(OH)D concentration, anthropometric parameters, body composition and visceral adiposity indices (LAP, VAI, NVAI) were assessed at baseline and after 3\u202fmonths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All groups showed significant reductions in anthropometric parameters after 3\u202fmonths. Notably, Group N achieved the greatest increase in serum 25(OH)D (+20\u202fng\/mL), the highest weight loss (\u22127.8 Kg) and a significant improvement in LAP and NVAI. In addition, only N group showed an increased fat-free mass. Regression analysis confirmed a significant association between calcifediol treatment and LAP reduction, independent of BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Calcifediol supplementation, combined with a MHD, is more effective than cholecalciferol in improving vitamin D status and reducing visceral adiposity in subjects with obesity. These findings support the recommended use of calcifediol supplementation in obesity-related vitamin D deficiency management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2025.1676668","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T05:18:30Z","timestamp":1763529510000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cholecalciferol vs. calcifediol supplementation on visceral adiposity in people with obesity: a real-world retrospective study"],"prefix":"10.3389","volume":"12","author":[{"given":"Martina","family":"Chiurazzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Di Lorenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Serena","family":"Lonardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariastella","family":"Di Lauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Onda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Sozio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pacella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunzia","family":"Cacciapuoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Guida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Menale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.3390\/nu15245033","article-title":"The 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