{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:14Z","timestamp":1787026934021,"version":"build-2736575974"},"reference-count":142,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CACMS Innovation Project","award":["CI2021B001"],"award-info":[{"award-number":["CI2021B001"]}]},{"name":"Basic Scientific Research Expenses of Central-Level Public Research Institutes","award":["YZX-202345"],"award-info":[{"award-number":["YZX-202345"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>No proven disease-modifying therapy exists for Parkinson\u2019s disease (PD), and prior single-target antioxidants have shown limited, unsustained benefits, highlighting the need for safe multi-target strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To synthesize how medicine\u2013food homology (MFH) compounds from Traditional Chinese Medicine (TCM)\u2014polysaccharides, saponins\/triterpenoids, polyphenols, carotenoids, and aromatic phenylpropanoids\u2014modulate oxidative stress and PD-related neurodegeneration, and to outline formulation routes toward dietary-supplement development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Web of Science Core Collection, Embase (Ovid), and the Cochrane Library from inception through August 1, 2025 with prespecified concept blocks (\u201cParkinson\u2019s disease,\u201d \u201coxidative stress,\u201d Nrf2\/ARE, NF-\u03baB, PI3K\/Akt, autophagy, and MFH terms). English-language in-vitro, invertebrate, and PD-specific rodent studies, selected epidemiology, and formulation\/dose\/regulatory reports were narratively appraised; no meta-analysis or tool-based risk-of-bias scoring was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MFH compounds converge on Nrf2\/ARE activation, NF-\u03baB suppression, autophagy promotion, and mitochondrial stabilization; nano-\/micro-delivery may improve bioavailability and brain exposure in preclinical models. Evidence is predominantly preclinical, with heterogeneous methods and sparse PD-specific randomized trials; epidemiologic signals are suggestive but non-causal. PD-specific oxidative stress arises from dopamine auto-oxidation, neuromelanin\u2013iron catalysis, and complex-I hypofunction; Latest studies further bind these to ferroptosis-linked lipid peroxidation. Clinical evidence remains sparse and PK-limited for MFH actives (e.g., curcumin, EGCG); dose\u2013response, safety monitoring (including liver signals for catechins), and regulatory constraints frame translation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MFH compounds are promising, hypothesis-generating candidates for adjunctive nutrition in PD, pending clinical dose\u2013response and long-term safety validation. No clinical efficacy has been established.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2025.1677749","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:14:48Z","timestamp":1763702088000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Medicine\u2013food homology bioactives in Parkinson\u2019s disease: multi-target oxidative-stress modulation and translation to dietary supplements"],"prefix":"10.3389","volume":"12","author":[{"given":"Meng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S2215-0366(24)00222-0","article-title":"Global 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