{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:32Z","timestamp":1787027012660,"version":"build-2736575974"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Food-specific IgG antibodies have been proposed to be biomarkers to identify food that triggers an inflammation response. We aimed to evaluate the effect of a food-specific IgG-based elimination diet by assessing the changes in the symptoms of migraine and its comorbidities, inflammatory cytokines, neuropeptides, and neurotransmitters, and their correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a sham-controlled randomized trial. A total of 98 patients with migraine who had at least one positive food-specific IgG antibody were randomly assigned to either the true diet group (IgG-positive foods were excluded,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952) or the sham diet group (alternative IgG-negative foods were excluded,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946). At baseline and at the end of 12\u2009weeks, seven questionnaires were administered regarding the symptoms of migraine, gastrointestinal symptoms, anxiety, depression, and sleep quality. Fourteen food-specific IgG antibodies, such as IL-6, IL-10, TNF-\u03b1, 5-HT, calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP), in serum were assessed using enzyme-linked immunosorbent assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the end of 12\u2009weeks, the true diet group had a larger reduction in questionnaires of migraine (except for MSQ), gastrointestinal symptoms, and poor sleeping, as well as food-specific positive IgG, IL-6, TNF-\u03b1, and CGRP in the serum. The difference in the change of \u201cdays with migraine in past 4\u2009weeks\u201d between the sham and true diet groups was significantly attenuated after adjusting for IL-6 and TNF-\u03b1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An IgG-positive food elimination diet improved migraine and its comorbidities and reduced IL-6, TNF-\u03b1, and CGRP, which might be associated with the alleviated systemic chronic inflammation and downregulation of the sensitivity of trigeminal nerve endings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>Chictr.org.cn<\/jats:ext-link>\n                      , identifier ChiCTR2000039278.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2025.1720389","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:30:33Z","timestamp":1765780233000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Food-specific IgG-based elimination diet decreased IL-6, TNF-\u03b1, and CGRP and improved symptoms in adults with 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