{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:30:54Z","timestamp":1790519454740,"version":"4.1.0"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    The crude polysaccharides of\n                    <jats:italic>Dendrobium findlayanum<\/jats:italic>\n                    were extracted by ethanol precipitation and separated using DEAE Sepharose Fast Flow and Sepharose 6 Fast Flow chromatography to obtain DFP-NP and its purified fraction DFP-NP1. Structural characterization revealed that DFP-NP (12.3\u202fkDa) primarily consisted of mannose, rhamnose, glucose, and galactose in a molar ratio of 11.61:0.68:84.78:2.93, with FT-IR spectra confirming typical polysaccharide functional groups.\n                    <jats:italic>In vitro<\/jats:italic>\n                    assays demonstrated that DFP-NP1 polysaccharides at concentrations of 5.0\u201320\u202f\u03bcg\/mL enhanced CAT and SOD activities and upregulated related gene expression in IPEC-J2 cells, while reducing TNF-\u03b1, IL-1\u03b2, and IL-6 secretion. They decreased expression levels of genes associated with the antioxidant signaling and cellular inflammatory pathways in IPEC-J2 cells. Therefore,\n                    <jats:italic>D. findlayanum<\/jats:italic>\n                    polysaccharides possess significant potential for application as a nutraceutical supplement to alleviate intestinal inflammation linked to oxidative stress, leveraging a dietary approach for health maintenance.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2025.1740458","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T15:20:58Z","timestamp":1765552858000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Isolation, purification, and characterization of polysaccharides from Dendrobium findlayanum: biological activities and potential therapeutic applications"],"prefix":"10.3389","volume":"12","author":[{"given":"Ji","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaowen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengliang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1111\/j.1365-3040.2009.01930.x","article-title":"The 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