{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T11:12:42Z","timestamp":1771931562640,"version":"3.50.1"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Refeeding syndrome (RFS) may have adverse effects on patients. However, the impact of RFS on the prognosis of severe stroke patients remain unclear. This study aims to explore the impact on short-term prognosis of patients with severe stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 305 patients were included for retrospective analysis. The electrolyte changes and short-term prognosis between RFS and Non-RFS (NRFS) groups of patients were compared. Besides, the risk factors for prognosis of patients and the predictive efficacy of RFS in patient prognosis were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The new acute liver injury (ALI), new acute kidney injury (AKI), new mechanical ventilation (MV), mortality within 28 d, and mRS scores at the discharge were higher in the RFS group than in the NRFS group (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The serum phosphorus level in the RFS group decreased after EN compared to before EN (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The area under the ROC curve (AUC) of RFS for predicting poor prognosis in patients with severe stroke was 0.678, with a sensitivity of 64.7%, and a specificity of 61.4%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RFS is an independent risk factor for the patient\u2019s functional prognosis, therefore, medical staff should screen high-risk populations as early as possible and provide preventive treatment according to the guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1682717","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:22:57Z","timestamp":1770873777000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact and predictive value of refeeding syndrome on the short-term prognosis of patients with severe stroke: a retrospective cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, The First Affiliated Hospital of Wannan Medical College","place":["Wuhu, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengxiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Intensive Care Unit, The First Affiliated Hospital of Wannan Medical College","place":["Wuhu, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Intensive Care Unit, The First Affiliated Hospital of Wannan Medical College","place":["Wuhu, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Intensive Care Unit, The First Affiliated Hospital of Wannan Medical College","place":["Wuhu, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.clnu.2017.12.014","article-title":"Risk factors for malnutrition in stroke patients: a meta-analysis","volume":"38","author":"Chen","year":"2019","journal-title":"Clin Nutr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s12028-017-0436-1","article-title":"Malnutrition in stroke patients: risk factors, assessment, and management","volume":"29","author":"Sabbouh","year":"2018","journal-title":"Neurocrit Care"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/ijs.12611","article-title":"One-year case fatality rate following stroke in the Mashhad stroke incidence study: a population-based study of stroke in 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unexpectedly high incidence of refeeding syndrome in patients with total parenteral nutrition in a reference university hospital","volume":"40","author":"De Vargas Cony","year":"2021","journal-title":"Clin Nutr"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.6133\/apjcn.2015.24.2.11","article-title":"Guidelines for parenteral and enteral nutrition support in geriatric patients in China","volume":"24","author":"Wei","year":"2015","journal-title":"Asia Pac J Clin Nutr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/ncp.10549","article-title":"Systematic review of energy initiation rates and refeeding syndrome outcomes","volume":"36","author":"Matthews-Rensch","year":"2021","journal-title":"Nutr Clin Pract Off Publ Am Soc Parenter Enter Nutr"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/j.clnu.2020.07.034","article-title":"Mortality associated with new risk classification of developing 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A systematic review and Meta-analyses of literature","volume":"40","author":"Cioffi","year":"2021","journal-title":"Clin Nutr"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1002\/jpen.2368","article-title":"Evaluation of the ASPEN guidelines for refeeding syndrome among hospitalized patients receiving enteral nutrition: a retrospective cohort study","volume":"46","author":"Adika","year":"2022","journal-title":"J Parenter Enter Nutr"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1177\/0148607115625638","article-title":"Association between malnutrition and clinical outcomes in the intensive care unit: a systematic review","volume":"41","author":"Lew","year":"2017","journal-title":"J Parenter Enter Nutr"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1682717\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:25:07Z","timestamp":1771928707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1682717\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":41,"alternative-id":["10.3389\/fnut.2026.1682717"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1682717","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"article-number":"1682717"}}