{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:35:40Z","timestamp":1789475740880,"version":"build-2803163510"},"reference-count":105,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Commission","doi-asserted-by":"crossref","award":["25Y42800200"],"award-info":[{"award-number":["25Y42800200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation General project","award":["82370859"],"award-info":[{"award-number":["82370859"]}]},{"name":"Key Laboratory of Exercise and Health Sciences (Shanghai University of Sport) Ministry of Education, the National Key R & D Program","award":["2023YFA1802000"],"award-info":[{"award-number":["2023YFA1802000"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2020YFA0803800"],"award-info":[{"award-number":["2020YFA0803800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271226"],"award-info":[{"award-number":["32271226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    This review systematically examines a novel therapeutic strategy for liver disease prevention and treatment by targeting magnesium ion homeostasis. Magnesium ions (Mg\n                    <jats:sup>2+<\/jats:sup>\n                    ), an essential macromineral, plays a critical role in energy metabolism and enzymatic activity, with its systemic balance maintained through intestinal absorption, renal excretion, and skeletal storage. Emerging evidence demonstrates that hypomagnesemia or intracellular magnesium deficiency is strongly associated with the development and progression of various liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcoholic liver disease (ALD), drug-induced liver injury (DILI), and hepatocellular carcinoma (HCC). Mechanistically, magnesium deficiency exacerbates hepatic pathology by promoting insulin resistance, impairing mitochondrial function, inducing oxidative stress and inflammatory responses, disrupting gut\u2013liver axis homeostasis, and compromising DNA repair and anti-tumor immunity. Preclinical and preliminary clinical studies indicate that restoring magnesium homeostasis\u2014through dietary supplementation, magnesium-based pharmacological agents, or modulation of magnesium transporters [e.g., inhibition of the Mg\n                    <jats:sup>2+<\/jats:sup>\n                    efflux transporter Cyclin M4 (CNNM4)]\u2014can improve metabolic function in hepatocytes, attenuate inflammation and fibrosis, and exert hepatoprotective effects. Collectively, these findings highlight magnesium homeostasis as a promising therapeutic target for liver disease, warranting further validation in large-scale clinical trials to facilitate clinical translation.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2026.1709477","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:42:33Z","timestamp":1772602953000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting magnesium homeostasis: a novel therapeutic strategy for liver diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Lili","family":"Ji","sequence":"first","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhan","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yin","sequence":"additional","affiliation":[{"name":"Research Department of Talent Identification and Development in Youth Sports, Shanghai Research Institute of Sports Science (Shanghai Anti-Doping Agency)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J Hepatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1016\/j.cgh.2023.04.015","article-title":"The global burden of liver disease","volume":"21","author":"Younossi","year":"2023","journal-title":"Clin Gastroenterol 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