{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:31:14Z","timestamp":1772159474831,"version":"3.50.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Postmenopause is commonly associated with vasomotor symptoms, musculoskeletal discomfort, weight gain, gastrointestinal (GI) disturbances, and increased cardiometabolic and autoimmune risk. A 52-year-old woman presented with hot flashes, weight gain, joint stiffness and pain, and abdominal bloating. Genomic profiling revealed variants affecting methylation, detoxification, and metabolic regulation. Functional testing identified global sex hormone decline, impaired Phase II estrogen metabolism, vitamin D insufficiency, an atherogenic lipid profile, increased intestinal permeability, and elevated toxin burden. A phased, precision nutrition plan was implemented, combining dietary modification, targeted nutraceuticals, gut-directed therapy, detoxification support, sleep optimization, and stress management, alongside bioidentical hormone replacement therapy (BHRT). After 6 months, the patient experienced resolution of vasomotor symptoms and GI bloating, marked reduction in musculoskeletal pain and Medical Symptoms Questionnaire (MSQ) scores, improved sleep quality, and favorable lipid changes. This case demonstrates the potential of genomically informed precision nutrition, integrated with functional testing, to guide personalized interventions that enhance metabolic health, symptom resolution, and overall quality of life (QoL) in postmenopausal women.<\/jats:p>","DOI":"10.3389\/fnut.2026.1724337","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T05:40:49Z","timestamp":1769406049000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Precision nutrition guided by genomic and functional assessments in postmenopause: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Jenny","family":"Noland","sequence":"first","affiliation":[{"name":"University of Western States","place":["Portland, OR, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.4103\/JMH.JMH_123_21","article-title":"Weight, shape, and body composition changes at menopause","volume":"12","author":"Fenton","year":"2021","journal-title":"J Midlife Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e225","DOI":"10.1016\/S2665-9913(23)00060-7\/ASSET\/3D182031-16EE-421E-84CB-BD49048CCA2C\/MAIN.ASSETS\/GR4.SML","article-title":"The influence of sex hormones on musculoskeletal pain and osteoarthritis","volume":"5","author":"Gulati","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S12016-025-09031-8","article-title":"The impact of menopause on autoimmune and rheumatic diseases","volume":"68","author":"Motta","year":"2025","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1080\/13697137.2024.2380363","article-title":"The musculoskeletal syndrome of menopause","volume":"27","author":"Wright","year":"2024","journal-title":"Climacteric"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/S41430-023-01377-6","article-title":"Personalized dietary management of advanced prostate cancer using nutrigenomics: a case report","volume":"78","author":"Brinkman","year":"2023","journal-title":"Eur J Clin Nutr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1451675","DOI":"10.3389\/FONC.2024.1451675","article-title":"The use of nutrigenomics and nutritional biomarkers with standard care of long-term recurrent metastatic rectal cancer: a case report","volume":"14","author":"Brinkman","year":"2024","journal-title":"Front Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000540337","article-title":"Precision nutrition for Management of Cardiovascular Disease Risk during Menopause","volume":"17","author":"Cabre","year":"2024","journal-title":"Lifestyle Genom"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"100549","DOI":"10.1016\/J.CLINSP.2024.100549","article-title":"Personalized nutrition and precision medicine in perimenopausal women: a minireview of genetic polymorphisms COMT, FUT2, and MTHFR","volume":"80","author":"Andrade","year":"2024","journal-title":"Clinics"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1017\/S0007114524001466","article-title":"The future backbone of nutritional science: integrating public health priorities with system-oriented precision nutrition","volume":"132","author":"Verg\u00e8res","year":"2024","journal-title":"Br J Nutr"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"E37148","DOI":"10.1097\/MD.0000000000037148","article-title":"Functional medicine health coaching improved elimination diet compliance and patient-reported health outcomes: results from a randomized controlled trial","volume":"103","author":"D\u2019Adamo","year":"2024","journal-title":"Medicine"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/S13065-021-00744-3","article-title":"Reliability of a dried urine test for comprehensive assessment of urine hormones and metabolites","volume":"15","author":"Newman","year":"2021","journal-title":"BMC Chem"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"651","DOI":"10.3390\/toxins14100651","article-title":"Development and validation of LC-Q-TOF-MS methodology to determine mycotoxin biomarkers in human urine","volume":"14","author":"Das\u00ed-Navarro","year":"2022","journal-title":"Toxins (Basel)"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1111\/J.1365-2672.2004.02409.X","article-title":"Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR","volume":"97","author":"Rinttil\u00e4","year":"2004","journal-title":"J Appl Microbiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"100985","DOI":"10.1016\/J.MGENE.2021.100985","article-title":"The association between CYP17A1, CYP19A1, and HSD17B1 gene polymorphisms of estrogen synthesis pathway and ovarian cancer predisposition","volume":"31","author":"Gowtham Kumar","year":"2022","journal-title":"Meta Gene"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3390\/IJMS15010712","article-title":"Analysis of the rs10046 polymorphism of aromatase (CYP19) in premenopausal onset of human breast Cancer","volume":"15","author":"Zins","year":"2014","journal-title":"Int J Mol Sci"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e11415","DOI":"10.1097\/MD.0000000000011415","article-title":"CYP17A1 rs743572 polymorphism might contribute to endometriosis susceptibility: evidences from a case\u2013control study","volume":"97","author":"Cong","year":"2018","journal-title":"Medicine"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1016\/J.FREERADBIOMED.2007.08.005","article-title":"Inhibition of catechol-O-methyltransferase increases estrogen-DNA adduct formation","volume":"43","author":"Zahid","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4103\/JMH.JMH_190_21","article-title":"The impact of soy Isoflavone supplementation on the menopausal symptoms in Perimenopausal and postmenopausal women","volume":"13","author":"Khapre","year":"2022","journal-title":"J Midlife Health"},{"key":"ref19","first-page":"273","article-title":"Effects of flaxseed and Hypericum perforatum on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women: a systematic review and meta-analysis","volume":"6","author":"Ghazanfarpour","year":"2016","journal-title":"Avicenna J Phytomed"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.4103\/JEHP.JEHP_81_17","article-title":"A comparative study on the effect of \"black cohosh\" and \"evening primrose oil\" on menopausal hot flashes","volume":"7","author":"Mehrpooya","year":"2018","journal-title":"J Educ Health Promot"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/S41430-023-01377-6","article-title":"Personalized dietary management of advanced prostate cancer using nutrigenomics: a case report","volume":"78","author":"Brinkman","year":"2023","journal-title":"Eur J Clin Nutr"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1724337\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:10:56Z","timestamp":1771924256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1724337\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":21,"alternative-id":["10.3389\/fnut.2026.1724337"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1724337","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]},"article-number":"1724337"}}