{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:55:09Z","timestamp":1790924109790,"version":"4.1.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Investment Project of Shanghai Science and Technology Service Industry","award":["24KF3501200"],"award-info":[{"award-number":["24KF3501200"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>International travel exposes individuals to abrupt environmental, dietary, and circadian changes that can disturb gut microbiota and overall well-being. While probiotics are known to support gastrointestinal and systemic health, their effects during short-term travel remain incompletely characterized in randomized trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized, double-blind, placebo-controlled study investigated whether a multi-strain\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      probiotic could maintain gut microbiota stability and support health during a five-day trip from China to Japan. Forty healthy adults were randomly assigned to receive either probiotic (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f22) or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f18) daily from Day 1 to Day 4. Stool samples collected before departure (Day 0) and after return (Day 5) were analyzed by metagenomic sequencing, quantitative PCR, and fecal secretory immunoglobulin A (sIgA) assays. Participants completed validated questionnaires on gastrointestinal and respiratory symptoms, sleep quality (PSQI), anxiety (GAD-7), and well-being (WHO-5).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with placebo, participants receiving the probiotic showed maintenance of microbial diversity (Chao1 and Fisher indices, both\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.044), prevented enrichment of potentially harmful taxa (\n                      <jats:italic>Bilophila<\/jats:italic>\n                      ,\n                      <jats:italic>Flavonifractor<\/jats:italic>\n                      ), and increased\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      abundance. Clinically, the probiotic group reported fewer respiratory and systemic symptoms, including sore throat (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.034) and fatigue (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.043). Sleep quality also improved, with longer sleep duration (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.023), fewer total occurrence days of PSQI &amp;gt;5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.009), lower anxiety scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.001) and higher WHO-5 well-being scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.041). Functional profiling showed up-regulation of vitamin biosynthesis pathways (folate, biotin, retinol) and decreased antibiotic resistance gene prevalence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Short-term probiotic administration demonstrated gut microbiota resilience and improved physiological and psychological stability during travel. Probiotics may serve as an accessible strategy to support well-being under transient environmental and lifestyle stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                      , identifier NCT07163819.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1724829","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T06:46:11Z","timestamp":1770878771000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Bifidobacterium supplementation maintains gut microbiota stability and enhances well-being during short-term travel"],"prefix":"10.3389","volume":"13","author":[{"given":"Long","family":"Wang","sequence":"first","affiliation":[{"name":"Tongji University Affiliated Shanghai Pulmonary Hospital","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yu","sequence":"additional","affiliation":[{"name":"Tongji University Affiliated Shanghai Pulmonary Hospital","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaxian","family":"Shen","sequence":"additional","affiliation":[{"name":"Tongji University Affiliated Shanghai Pulmonary Hospital","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Immunology, and Metabolism, DiPROBIO (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Immunology, and Metabolism, DiPROBIO (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhai","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Immunology, and Metabolism, DiPROBIO (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Immunology, and Metabolism, DiPROBIO (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Immunology, and Metabolism, DiPROBIO (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Immunology, and Metabolism, DiPROBIO (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Tze","family":"Liong","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Immunology, and Metabolism, DiPROBIO (Shanghai) Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Immunology, and Metabolism, DiPROBIO (Shanghai) Co., Ltd.","place":["Shanghai, China"]},{"name":"DiPRO Microecological Health Management Center","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Vanke School of Public Health, Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"102747","DOI":"10.1016\/j.tmaid.2024.102747","article-title":"Human gut microbiota composition associated with international travels","volume":"61","author":"Henares","year":"2024","journal-title":"Travel Med Infect Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.3390\/biomedicines12071378","article-title":"Exploring the impact of short term travel on gut microbiota and probiotic bacteria mediated stability","volume":"12","author":"Zhao","year":"2024","journal-title":"Biomedicine"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7485","DOI":"10.1038\/s41467-022-34862-w","article-title":"Impact of international travel and diarrhea on gut microbiome and resistome 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