{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:04:16Z","timestamp":1771567456267,"version":"3.50.1"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012228","name":"Development and Reform Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["XMHT20220104055"],"award-info":[{"award-number":["XMHT20220104055"]}],"id":[{"id":"10.13039\/501100012228","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D is essential for calcium homeostasis, bone health, and immune function, yet its association with serum uric acid (UA) remains uncertain. This study evaluates vitamin D status in Chinese adults and explores its sex- and age-specific relationships with UA and hyperuricemia (HUA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional analysis of 15,116 males and 25,895 females from The China Precision Nutrition and Health KAP Real World Study (CPNAS). Restricted cubic spline (RCS) visualized dose-response relationships, while multivariate regression assessed associations between vitamin D and UA\/HUA. Subgroup analyses (age &amp;lt; 70 vs. \u226570, male vs. female) explored potential variations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study revealed a high prevalence of vitamin D deficiency (33.5%) and insufficiency (53%) in Chinese adults. Among males under 70 years, we observed an inverse J-shaped relationship between vitamin D and serum UA levels (\n                      <jats:italic>P<\/jats:italic>\n                      -non-linear = 0.046). Compared to those with vitamin D &amp;lt; 22 ng\/ml, participants with moderate levels (22\u201330 ng\/ml) showed significantly lower UA (\u03b2 = \u22125.40 to \u22124.36, all\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05), while no significant reduction occurred at higher concentrations (\u226525.8\u201330 ng\/ml,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;gt; 0.05). Notably, this association was absent in males \u226570 years. In contrast, females exhibited a consistent positive linear relationship between vitamin D and UA. These patterns were similarly observed for hyperuricemia risk in both sexes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D levels are differentially associated with UA and HUA based on sex and age, highlighting the need for personalized approaches in managing vitamin D and UA metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      This trial was registered at\n                      <jats:ext-link>https:\/\/www.chictr.org.cn\/hvshowproject.html?id=178499&amp;amp;v=2.2<\/jats:ext-link>\n                      , as ChiCTR2100051983.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1726451","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:21:13Z","timestamp":1771564873000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between vitamin D and serum uric acid in a large Chinese cohort of middle-aged and elderly Chinese men and women"],"prefix":"10.3389","volume":"13","author":[{"given":"Rong","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Geriatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou","place":["Fujian, China"]},{"name":"Department of General Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou","place":["Fujian, China"]},{"name":"Clinical Research Center for Geriatric Hypertension Disease of Fujian Province, The First Affiliated Hospital of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Branch of National 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