{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:02:11Z","timestamp":1791957731909,"version":"4.3.4"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Conventional treatments for depression and anxiety, including pharmacotherapy and psychotherapy, often fail to achieve long-term symptom remission and are associated with side effects, limited accessibility, and high attrition. Ketogenic metabolic therapy (KMT) has emerged as a potential adjunctive intervention, with studies showing improvements in metabolic and mental health outcomes. However, research on remotely delivered, group-based KMT remains limited. This study evaluates the feasibility of an online, group-based KMT program integrating psychoeducation, professional guidance, and community support on symptoms of depression and anxiety in adults with varying mental health conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective evaluation of 19 self-referred participants with baseline PHQ-9 and GAD-7 scores &amp;gt; 4. Participants followed a ketogenic diet tailored to individual macronutrient targets. Depression (PHQ-9) and anxiety (GAD-7) were assessed at baseline, 4, 8, and 12 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean PHQ-9 scores decreased from 13 to 5 over 12 weeks, representing a 62% reduction, with 71% achieving clinically meaningful improvement. Mean GAD-7 scores decreased from 13 to 7, a 46% reduction, with 79% achieving clinically meaningful improvement. Eight participants reached remission for depression and nine for anxiety. Participants achieved blood ketone levels &amp;gt; 0.5 mmol\/L 85% of the time, indicating high adherence with mean ketone levels of 1.1 mmol\/L. No serious adverse events were reported, and all participants completed the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This remotely delivered, group-based KMT appears feasible and was associated with clinically meaningful reductions in depression and anxiety over 12 weeks. These findings support the potential of KMT as a scalable, transdiagnostic approach to conventional psychiatric care. Future research should evaluate larger samples and longer-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1751564","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:01:35Z","timestamp":1772607695000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["A retrospective evaluation of an online group ketogenic metabolic therapy intervention on mental health outcomes"],"prefix":"10.3389","volume":"13","author":[{"given":"Erin L.","family":"Bellamy","sequence":"first","affiliation":[{"name":"School of Psychology, University of East London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1017\/S0033291723003306","article-title":"Is combined antidepressant medication (ADM) and psychotherapy better than either monotherapy at preventing suicide attempts and other psychiatric serious adverse events for depressed patients? 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