{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:03:06Z","timestamp":1780984986382,"version":"3.54.1"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    <jats:italic>Trichosanthis Semen<\/jats:italic>\n                    (TS) is widely used as both a food and traditional medicine. It is rich in diverse compounds (e.g., fatty acids, amino acids, and terpenes), which contribute to its functional and sensory properties. Stir-frying alters the functional and sensory properties of TS, yet the underlying chemical basis remains unclear. In this study, an integrated untargeted metabolomics and lipidomics strategy based on liquid chromatography-high resolution mass spectrometry (LC-HRMS) was employed to characterize compositional differences between raw and stir-fried TS. A total of 144 metabolites and 295 lipids were identified. Omics analysis revealed that 29 metabolites and 54 lipids exhibited significant changes after stir-frying, of which 25 compounds showed increased abundance. Based on these differential compounds, molecular docking suggested that 19 upregulated compounds may have potential relevance to constipation-related regulation, while sensory analysis tentatively linked 39 altered compounds to taste-related attributes. Overall, this study provides a comprehensive chemical profiling of TS and offers a preliminary link between processing-induced chemical changes and functional as well as sensory properties.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2026.1754969","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:41:03Z","timestamp":1780983663000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated untargeted metabolomics and lipidomics reveals functional- and taste-related compounds in stir-fried Trichosanthis Semen"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuan","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Massage, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Massage, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Massage, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Massage, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.19540\/j.cnki.cjcmm.20210923.401","article-title":"Study on anticoagulant material basis and mechanism of Trichosanthis semen and its shell and kernel based on spectrum-effect relationship integrated molecular docking","volume":"47","author":"Yan","year":"2022","journal-title":"China J Chinese Materia Medica"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.16155\/j.0254-1793.2005.04.002","article-title":"RP-HPLC quantitative analysis of 3, 29-dibenzoyl-karounitriol in semen trichosanthis","volume":"25","author":"Chen","year":"2005","journal-title":"Chinese J Pharma Analysis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"14015","DOI":"10.3390\/ijms232214015","article-title":"Trichosanthis semen and Zingiberis rhizoma mixture ameliorates 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