{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:47:30Z","timestamp":1788997650668,"version":"build-2803163510"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This case report examines the application of ketogenic metabolic therapy (KMT), also known as the ketogenic diet, in a patient with treatment-resistant Post-Traumatic Stress Disorder (PTSD) resulting from military sexual trauma (MST) who was nonresponsive to conventional interventions including psychotherapy and pharmacotherapy. Metabolic dysfunction can contribute to persistent symptoms highlighting the need for novel treatment approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on a 45-year-old female patient who underwent a structured ketogenic dietary intervention for 25\u202fweeks. Therapeutic carbohydrate restriction was initiated by the patient 9\u202fdays before formal treatment with rapid and early improvements in mood prior to working with the KMT professional. Clinical response was monitored using validated instruments, including Post-Traumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 (PCL-5), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Depression Anxiety Stress Scales-42 (DASS-42), as well as daily metabolic measurements assessing nutritional ketosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Quantitative assessments demonstrated significant clinical improvement. The PCL-5 score decreased from 32 at the intervention baseline to 2 at 27\u202fweeks. The PHQ-9 score declined from 10 to 0 and the GAD-7 score decreased from 6 to 0. DASS-42 further confirmed the resolution of depressive, anxious, and stress symptoms. Qualitative data corroborated these findings, with the patient reporting enhanced mood stability, improved cognitive function, and a renewed sense of emotional wellbeing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Targeted KMT may be effective against the metabolic dysfunction underlying treatment-resistant PTSD. The consistent improvements across multiple psychometric assessments, supported by qualitative reports, warrant further controlled investigations into the clinical utility of this intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1755107","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T06:34:44Z","timestamp":1771310084000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ketogenic metabolic therapy for treatment-resistant post-traumatic stress disorder (PTSD): a retrospective case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Nicole","family":"Laurent","sequence":"first","affiliation":[{"name":"Family Renewal, Inc.","place":["Vancouver, WA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"ref1","first-page":"947","volume-title":"Diagnostic and statistical manual of mental disorders, fifth edition, text revision (DSM-5-TR)","year":"2022"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1080\/03007995.2021.1978417","article-title":"Prevalence of post-traumatic stress disorder in the United States: a systematic literature review","volume":"37","author":"Schein","year":"2021","journal-title":"Curr Med Res Opin"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e2413874","DOI":"10.1001\/jamanetworkopen.2024.13874","article-title":"Trends in diagnosed posttraumatic stress disorder and acute stress disorder in US College students, 2017-2022","volume":"7","author":"Zhai","year":"2024","journal-title":"JAMA Netw Open"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.3390\/nu16111546","article-title":"The potential effects of the ketogenic diet in the prevention and co-treatment of stress, anxiety, depression, schizophrenia, and bipolar disorder: from the basic research to the clinical practice","volume":"16","author":"Chrysafi","year":"2024","journal-title":"Nutrients"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1266575","DOI":"10.3389\/fphys.2023.1266575","article-title":"Potential oxidative stress related targets of mitochondria-focused therapy of PTSD","volume":"14","author":"Kmita","year":"2023","journal-title":"Front Physiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40501-024-00339-4","article-title":"The ketogenic diet as a transdiagnostic treatment for neuropsychiatric disorders: mechanisms and clinical outcomes","volume":"12","author":"Anderson","year":"2024","journal-title":"Curr Treat Options Psych"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s40501-024-00322-z","article-title":"The ketogenic diet as a treatment for mood disorders","volume":"11","author":"Ozan","year":"2024","journal-title":"Curr Treat Options Psych"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"9899034","DOI":"10.1155\/2024\/9899034","article-title":"Prevalence and predictors of nonresponse to psychological treatment for PTSD: a meta-analysis","volume":"2024","author":"Semmlinger","year":"2024","journal-title":"Depress Anxiety"},{"key":"ref9","first-page":"CD002795","author":"Williams","year":""},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e44905","DOI":"10.7759\/cureus.44905","article-title":"Post-traumatic stress disorder: a narrative review of pharmacological and psychotherapeutic interventions","volume":"15","author":"Mansour","year":"2023","journal-title":"Cureus"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1192\/bjp.bp.114.148551","article-title":"Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis","volume":"206","author":"Hoskins","year":"2015","journal-title":"Br J Psychiatry"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3389\/fnbeh.2018.00258","article-title":"Treating PTSD: a review of evidence-based psychotherapy interventions","volume":"12","author":"Watkins","year":"2018","journal-title":"Front Behav Neurosci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1017\/S0033291723003446","article-title":"EMDR v. other psychological therapies for PTSD: a systematic review and individual participant data meta-analysis","volume":"54","author":"Wright","year":"2024","journal-title":"Psychol Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"6376","DOI":"10.1017\/S0033291722003737","article-title":"Comparative effectiveness of psychotherapies in adults with posttraumatic stress disorder: a network meta-analysis of randomised controlled trials","volume":"53","author":"Yunitri","year":"2023","journal-title":"Psychol Med"},{"key":"ref15","volume-title":"Guidelines on key considerations for working with adults with PTSD and traumatic stress disorders [Professional Practice Guideline]","author":"Walker","year":"2024"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"102611","DOI":"10.1016\/j.janxdis.2022.102611","article-title":"Is it worth it to personalize the treatment of PTSD? \u2013 a variance-ratio meta-analysis and estimation of treatment effect heterogeneity in RCTs of PTSD","volume":"91","author":"Herzog","year":"2022","journal-title":"J Anxiety Disord"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/phar.2767","article-title":"Adverse effects of antidepressant medications and their management in children and adolescents","volume":"43","author":"Strawn","year":"2023","journal-title":"Pharmacotherapy"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3783","DOI":"10.1017\/S0033291723001630","article-title":"Incidence of adverse events and comparative tolerability of selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for the treatment of anxiety, obsessive-compulsive, and stress disorders: a systematic review and network meta-analysis","volume":"53","author":"Gosmann","year":"2023","journal-title":"Psychol Med"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1002\/pds.5653","article-title":"Selective serotonin reuptake inhibitors, post-treatment sexual dysfunction and persistent genital arousal disorder: a systematic review","volume":"32","author":"Tarchi","year":"2023","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1176\/appi.ajp.2020.20050596","article-title":"A randomized controlled trial of repeated ketamine administration for chronic posttraumatic stress disorder","volume":"178","author":"Feder","year":"2021","journal-title":"AJP"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2299124","DOI":"10.1080\/20008066.2023.2299124","article-title":"So how special is special K? A systematic review and meta-analysis of ketamine for PTSD RCTs","volume":"15","author":"Borgogna","year":"2024","journal-title":"Eur J Psychotraumatol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"20451253231154125","DOI":"10.1177\/20451253231154125","article-title":"The potential of ketamine for posttraumatic stress disorder: a review of clinical evidence","volume":"13","author":"Ragnhildstveit","year":"2023","journal-title":"Therap Adv Psychopharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/wps.21269","article-title":"Post-traumatic stress disorder: evolving conceptualization and evidence, and future research directions","volume":"24","author":"Brewin","year":"2025","journal-title":"World Psychiatry"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3233\/JAD-190913","article-title":"Amyloid-\u03b2, tau, and 18F-fluorodeoxyglucose positron emission tomography in posttraumatic stress disorder","volume":"73","author":"Elias","year":"2020","journal-title":"J Alzheimer's Dis"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e3387","DOI":"10.1097\/MD.0000000000003387","article-title":"Analysis of the metabolic and structural brain changes in patients with torture-related post-traumatic stress disorder (TR-PTSD) using 18F-FDG PET and MRI","volume":"95","author":"Zandieh","year":"2016","journal-title":"Medicine"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.expneurol.2016.05.038","article-title":"Posttraumatic stress disorder: a metabolic disorder in disguise?","volume":"284","author":"Michopoulos","year":"2016","journal-title":"Exp Neurol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.36148\/2284-0249-372","article-title":"Metabolic dysfunctions in people with post-traumatic stress disorder","volume":"26","author":"Bartoli","year":"2020","journal-title":"J Psychopathol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.biopsych.2025.01.014","article-title":"Grasping posttraumatic stress disorder from the perspective of psychoneuroimmunoendocrinology: etiopathogenic mechanisms and relevance for integrative management","volume":"98","author":"Fraile-Martinez","year":"2025","journal-title":"Biol Psychiatry"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/FBP.0000000000000467","article-title":"Animal models of post-traumatic stress disorder and novel\u2026: behavioural pharmacology","volume":"30","author":"Aspesi","year":"2019","journal-title":"Behav Pharmacol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1130861","DOI":"10.3389\/fphys.2023.1130861","article-title":"Defining the nuanced nature of redox biology in post-traumatic stress disorder","volume":"14","author":"Reed","year":"2023","journal-title":"Front Physiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1341204","DOI":"10.3389\/fphys.2023.1341204","article-title":"Editorial: role of mitochondria in post-traumatic stress disorder (PTSD)","volume":"14","author":"Pinna","year":"2023","journal-title":"Front Physiol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"105450","DOI":"10.1016\/j.neubiorev.2023.105450","article-title":"The human affectome","volume":"158","author":"Schiller","year":"2024","journal-title":"Neurosci Biobehav Rev"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.phrs.2019.02.001","article-title":"Recent advances in the neurobiology of posttraumatic stress disorder: a review of possible mechanisms underlying an effective pharmacotherapy","volume":"142","author":"Malikowska-Racia","year":"2019","journal-title":"Pharmacol Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/annurev-clinpsy-082719-104030","article-title":"Stress and psychiatric disorders: the role of mitochondria","volume":"16","author":"Daniels","year":"2020","journal-title":"Annu Rev Clin Psychol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1105839","DOI":"10.3389\/fphys.2023.1105839","article-title":"Mitochondrial dysfunction in animal models of PTSD: relationships between behavioral models, neural regions, and cellular maladaptation","volume":"14","author":"Kaplan","year":"2023","journal-title":"Front Physiol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.3390\/biomedicines11092488","article-title":"Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities","volume":"11","author":"Clemente-Su\u00e1rez","year":"2023","journal-title":"Biomedicine"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"167","DOI":"10.47626\/2237-6089-2020-0099","article-title":"Neuroprogression in post-traumatic stress disorder: a systematic review","volume":"43","author":"Antonelli-Salgado","year":"2021","journal-title":"Trends Psychiatry Psychother"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.3390\/ijerph20042937","article-title":"Metabolic and inflammatory response in post-traumatic stress disorder (PTSD): a systematic review on peripheral neuroimmune biomarkers","volume":"20","author":"Dell\u2019Oste","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1123692","DOI":"10.3389\/fphys.2023.1123692","article-title":"Immune-metabolic mechanisms of post-traumatic stress disorder and atherosclerosis","volume":"14","author":"Tian","year":"2023","journal-title":"Front Physiol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3390\/antiox9020107","article-title":"Inflammation in post-traumatic stress disorder (PTSD): a review of potential correlates of PTSD with a neurological perspective","volume":"9","author":"Kim","year":"2020","journal-title":"Antioxidants"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3390\/biomedicines10050953","article-title":"Neuroinflammation in post-traumatic stress disorder","volume":"10","author":"Lee","year":"2022","journal-title":"Biomedicine"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.3390\/nu14091952","article-title":"The therapeutic role of ketogenic diet in neurological disorders","volume":"14","author":"Pietrzak","year":"2022","journal-title":"Nutrients"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.3390\/jcm13102819","article-title":"The potential role of the ketogenic diet in serious mental illness: current evidence, safety, and practical advice","volume":"13","author":"Rog","year":"2024","journal-title":"J Clin Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/MED.0000000000000564","article-title":"Ketogenic diet as a metabolic treatment for mental illness","volume":"27","author":"Norwitz","year":"2020","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"101079","DOI":"10.37349\/eff.2025.101079","article-title":"Therapeutic effects of ketogenic diets on physiological and mental health","volume":"3","author":"Borrego-Ruiz","year":"2025","journal-title":"Explor Foods Foodomics"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"55722","DOI":"10.12775\/JEHS.2024.70.55722","article-title":"Metabolic reprogramming via ketogenic diet: a novel approach to combating neurological diseases","volume":"70","author":"Karo\u0144","year":"2024","journal-title":"J Educ Health Sport"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"78","DOI":"10.52403\/ijhsr.20250111","article-title":"Ketosis based therapy for psychiatric conditions","volume":"15","author":"Sireesha","year":"2025","journal-title":"Int J Health Sci Res"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1396685","DOI":"10.3389\/fnut.2024.1396685","article-title":"Complete remission of depression and anxiety using a ketogenic diet: case series","volume":"11","author":"Calabrese","year":"2024","journal-title":"Front Nutr"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1600123","DOI":"10.3389\/fnut.2025.1600123","article-title":"Transdiagnostic remission of psychiatric comorbidity in post-traumatic stress disorder, ADHD, and binge-eating disorder using ketogenic metabolic therapy: a retrospective case report","volume":"12","author":"Bellamy","year":"2025","journal-title":"Front Nutr"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1406366","DOI":"10.3389\/fnut.2024.1406366","article-title":"Exploring diet-induced ketosis with exogenous ketone supplementation as a potential intervention in post-traumatic stress disorder: a feasibility study","volume":"11","author":"Edwards","year":"2024","journal-title":"Front Nutr"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3389\/fpsyt.2019.00363","article-title":"Therapeutic potential of exogenous ketone supplement induced ketosis in the treatment of psychiatric disorders: review of current literature","volume":"10","author":"Kov\u00e1cs","year":"2019","journal-title":"Front Psych"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/jts.22059","article-title":"The posttraumatic stress disorder checklist for DSM-5 (PCL-5): development and initial psychometric evaluation","volume":"28","author":"Blevins","year":"2015","journal-title":"J Trauma Stress"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1037\/pas0000254","article-title":"Psychometric properties of the PTSD checklist for diagnostic and statistical manual of mental disorders\u2013fifth edition (PCL-5) in veterans","volume":"28","author":"Bovin","year":"2016","journal-title":"Psychol Assess"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e0161645","DOI":"10.1371\/journal.pone.0161645","article-title":"Psychometric validation of the English and French versions of the posttraumatic stress disorder checklist for DSM-5 (PCL-5)","volume":"11","author":"Ashbaugh","year":"2016","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1192\/bja.2024.27","article-title":"Assessment and diagnosis of post-traumatic stress disorders (PTSDs) for medico-legal and other clinical purposes: DSM-5-TR PTSD, ICD-11 PTSD and ICD-11 complex PTSD","volume":"30","author":"Siddaway","year":"2024","journal-title":"BJPsych Adv"},{"key":"ref56","first-page":"42","volume-title":"Manual for the depression anxiety stress scales","author":"Lovibond","year":"1996"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1037\/t01004-000","article-title":"Depression anxiety stress scales","author":"Lovibond","year":"2011","journal-title":"Psychol Assess"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3928\/0048-5713-20020901-06","article-title":"The PHQ-9: a new depression diagnostic and severity measure","volume":"32","author":"Kroenke","year":"2002","journal-title":"Psychiatr Ann"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1080\/19012276.2023.2279904","article-title":"Can GAD-7 be used reliably to capture anxiety?: approaching evaluation of item quality using IRT","volume":"76","author":"Omarsdottir","year":"2024","journal-title":"Nord Psychol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1192\/bjp.bp.110.083733","article-title":"Conceptual framework for personal recovery in mental health: systematic review and narrative synthesis","volume":"199","author":"Leamy","year":"2011","journal-title":"Br J Psychiatry"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1080\/15374416.2014.910791","article-title":"Qualitative methods in mental health services research","volume":"43","author":"Palinkas","year":"2014","journal-title":"J Clin Child Adolesc Psychol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e13433","DOI":"10.1111\/inm.13433","article-title":"\u2018My journey\u2019: a qualitative study of recovery from the perspective of individuals with chronic mental illness","volume":"34","author":"Y\u00fcksel","year":"2025","journal-title":"Int J Ment Health Nurs"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.psychres.2019.04.022","article-title":"Predictors of dropout from a randomized clinical trial of cognitive processing therapy for female veterans with military sexual trauma-related PTSD","volume":"276","author":"Holder","year":"2019","journal-title":"Psychiatry Res"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.whi.2020.07.004","article-title":"Emotion dysregulation predicts dropout from prolonged exposure treatment among female veterans with military sexual trauma-related posttraumatic stress disorder","volume":"30","author":"Gilmore","year":"2020","journal-title":"Womens Health Issues"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.brat.2019.03.003","article-title":"Predictors of attendance and dropout in three randomized controlled trials of PTSD treatment for active duty service members","volume":"118","author":"Berke","year":"2019","journal-title":"Behav Res Ther"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.bbi.2023.09.005","article-title":"The emerging role of the gut microbiome in posttraumatic stress disorder","volume":"114","author":"Ke","year":"2023","journal-title":"Brain Behav Immun"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.14336\/AD.2021.1217","article-title":"Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases","volume":"13","author":"Jiang","year":"2022","journal-title":"Aging Dis"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1425816","DOI":"10.3389\/fimmu.2024.1425816","article-title":"Exploring the ketogenic diet\u2019s potential in reducing neuroinflammation and modulating immune responses","volume":"15","author":"Monda","year":"2024","journal-title":"Front Immunol"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s00702-023-02620-x","article-title":"Ketogenic diet for mood disorders from animal models to clinical application","volume":"130","author":"Smolensky","year":"2023","journal-title":"J Neural Transm (Vienna)"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"112654","DOI":"10.1016\/j.physbeh.2019.112654","article-title":"Attenuation of stress-induced weight loss with a ketogenic diet","volume":"212","author":"Sahagun","year":"2019","journal-title":"Physiol Behav"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"9301369","DOI":"10.1155\/2024\/9301369","article-title":"Three weeks on a ketogenic diet reduces free testosterone and free estradiol in middle-aged obese men and women","volume":"2024","author":"Svart","year":"2024","journal-title":"J Nutr Metab"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1755107\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T11:29:47Z","timestamp":1771932587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1755107\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":72,"alternative-id":["10.3389\/fnut.2026.1755107"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1755107","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"article-number":"1755107"}}