{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:52:26Z","timestamp":1781884346354,"version":"3.54.5"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Percutaneous endoscopic gastrostomy (PEG) is commonly used to manage dysphagia and nutritional failure, which are among the most frequent and severe complications of amyotrophic lateral sclerosis (ALS). While several studies assessed PEG indications, outcomes, and prognostic factors, there is no evidence regarding ALS patients\u2019 perspectives and health-related quality of life (HRQoL) associated with PEG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 48 consecutive ALS patients. At the 1-month follow-up after PEG, patients and their caregivers completed a PEG satisfaction questionnaire regarding their decision to proceed with the PEG-tube placement. HRQoL was assessed using the Gastrointestinal Quality of Life Index (GIQLI) and the Short Form-36 (SF-36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 77.1% of patients and 88.9% of caregivers confirmed that they would prefer to have a PEG tube placed again if required (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.001); 93.8% of patients felt that PEG made feeding easier, exerting a positive effect on overall wellbeing (83.3%) and increasing survival rates (93.8%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.001); 54.2% felt that PEG was cosmetically acceptable. Consistent positive rates were reported by caregivers. The GIQLI digestion subscale values significantly improved from baseline (28.3; SD\u202f=\u202f6.6) to discharge (30.97, SD\u202f=\u202f5.84) and were maintained at 1-month follow-up (30.21, SD\u202f=\u202f6.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.014). Conversely, in follow-up assessments, we observed a significant reduction in the SF-36 physical component summary (PCS) subscale (baseline\u202f=\u202f33.3; 1-month follow-up\u202f=\u202f28.61;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.032), which was accompanied by a significant worsening in the GIQLI physical dimension subscale (baseline\u202f=\u202f9.63; 1-month follow-up\u202f=\u202f7.38;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.044).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study provides preliminary evidence that ALS patients have a positive perspective on PEG positioning, which may also have a beneficial effect on HRQoL related to gastrointestinal function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1756642","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:01:10Z","timestamp":1781881270000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Perspective and quality of life in amyotrophic lateral sclerosis patients undergoing percutaneous endoscopic gastrostomy"],"prefix":"10.3389","volume":"13","author":[{"given":"Nilo","family":"Riva","sequence":"first","affiliation":[{"name":"Neurology and Neuro-rehabilitation Unit, Division of Neuroscience, IRCCS San Raffaele","place":["Milan, Italy"]},{"name":"Experimental Neuropathology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Finotto","sequence":"additional","affiliation":[{"name":"Neurology and Neuro-rehabilitation 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Italy"]},{"name":"Experimental Neuropathology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teuta","family":"Domi","sequence":"additional","affiliation":[{"name":"Experimental Neuropathology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Experimental Neuropathology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tettamanti","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Functional Recovery, IRCCS San Raffaele Scientific Institute","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Riboldi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Functional Recovery, IRCCS San Raffaele Scientific Institute","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio Diego","family":"Lopez","sequence":"additional","affiliation":[{"name":"Neurology and Neuro-rehabilitation Unit, Division of Neuroscience, IRCCS San Raffaele","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Quattrini","sequence":"additional","affiliation":[{"name":"Experimental Neuropathology Unit, Division of Neuroscience, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Cremona","sequence":"additional","affiliation":[{"name":"Unit of Respiratory Medicine, IRCCS San Raffaele Scientific Institute","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Comola","sequence":"additional","affiliation":[{"name":"Neurology and Neuro-rehabilitation Unit, Division of Neuroscience, IRCCS San Raffaele","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[{"name":"Neurology and Neuro-rehabilitation Unit, Division of Neuroscience, IRCCS San Raffaele","place":["Milan, Italy"]},{"name":"Vita-Salute San Raffaele University","place":["Milan, 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