{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:50:34Z","timestamp":1782190234415,"version":"3.54.5"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prognostic significance of body mass index (BMI) in diffuse large B-cell lymphoma (DLBCL) remains uncertain. We conducted a systematic review and meta-analysis to evaluate the associations between BMI and overall survival (OS) and progression-free survival (PFS) in patients with DLBCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of the Cochrane Library, PubMed, and Embase was conducted up to April 14, 2026, with additional reference screening. Random-effects models were used to calculate pooled hazard ratios (HRs) and 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 764 records identified, 23 studies were included. In the main analyses, overweight status, defined according to study-specific thresholds, including Asian-specific cutoffs where applicable, was associated with better OS (HR = 0.82, 95% CI: 0.73\u20130.92,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001) and PFS (HR = 0.83, 95% CI: 0.72\u20130.96,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.011). These associations remained consistent in subgroup analyses restricted to studies using R-CHOP-like regimens, multivariable-adjusted estimates, and normal-weight patients as the reference group. In BMI category-specific analyses, underweight status was associated with inferior OS (HR = 1.85, 95% CI: 1.30\u20132.64,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001) and PFS (HR = 1.64, 95% CI: 1.11\u20132.42,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.013). By contrast, overweight status was associated with better OS (HR = 0.77, 95% CI: 0.70\u20130.84,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001) and PFS (HR = 0.80, 95% CI: 0.69\u20130.93,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004). Obesity was not significantly associated with either OS (HR = 0.93, 95% CI: 0.75\u20131.15,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.508) or PFS (HR = 0.95, 95% CI: 0.80\u20131.13,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.541).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Available evidence suggests that overweight status may be associated with better survival outcomes in DLBCL, whereas underweight status may be associated with poorer prognosis. Current evidence remains insufficient to confirm a significant prognostic impact of obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/<\/jats:ext-link>\n                      , identifier: CRD42024607212.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1762123","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:34:34Z","timestamp":1782189274000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the prognostic value of body mass index in diffuse large B-cell lymphoma: a systematic review and 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