{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:46:13Z","timestamp":1782279973297,"version":"3.54.5"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malnutrition and nutrition-related abnormalities are common in people with kidney failure, particularly among patients receiving maintenance hemodialysis, and are associated with adverse clinical outcomes. Nutritional status and related biological processes are dynamic; however, the prognostic relevance of their longitudinal changes remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the associations between longitudinal trajectories of nutrition-related biomarkers and all-cause mortality in patients receiving maintenance hemodialysis using joint modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective longitudinal cohort study included 345 maintenance hemodialysis patients, among whom 99 deaths occurred during follow-up. Longitudinal changes in nutrition-related biomarkers were analyzed in relation to all-cause mortality using joint models that integrate repeated biomarker measurements with time-to-event outcomes. Dynamic prediction was evaluated using a fixed 12-month prediction horizon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In adjusted univariable joint models, several longitudinal biomarkers were associated with all-cause mortality. In the primary multivariable joint model incorporating longitudinal C-reactive protein (CRP) and serum iron, the current value of CRP was positively associated with mortality risk (HR, 1.030; 95% credible interval [CrI], 1.001\u20131.058), as was the current value of serum iron (HR, 1.073; 95% CrI, 1.015\u20131.132). Across landmark times from 6 to 36\u202fmonths, time-dependent AUC values ranged from 0.756 to 0.807 for 12-month dynamic prediction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current values of CRP and serum iron were positively associated with all-cause mortality in maintenance hemodialysis patients. Joint modeling of repeated biomarker measurements may help characterize dynamic nutrition-related inflammatory and metabolic risk in kidney failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1769563","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:46:06Z","timestamp":1782276366000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal trajectories of nutrition-related biomarkers and mortality risk in maintenance hemodialysis patients: a joint modeling analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Min-Jia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Yuedong Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Yuedong Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Yuedong Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Yuedong Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Yuedong Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Lan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Yuedong Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Yuedong Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/j.clnu.2019.07.029","article-title":"Predictors of nutritional and inflammation risk in hemodialysis patients","volume":"39","author":"Martins","year":"2020","journal-title":"Clin Nutr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/ki.2013.147","article-title":"Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism","volume":"84","author":"Ikizler","year":"2013","journal-title":"Kidney Int"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1111\/j.1523-1755.2004.00515.x","article-title":"Disparity in outcomes for adult native American hemodialysis patients? 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