{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:37:33Z","timestamp":1791308253732,"version":"4.3.1"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity constitutes a pressing global public health challenge, characterized by intricate associations with metabolic dysregulation and gut microbiota dysbiosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study systematically evaluated the anti-obesity efficacy and underlying mechanisms of\n                      <jats:italic>Gnaphalium affine<\/jats:italic>\n                      methanol extract (GAE) in high-fat diet (HFD)-induced obese mice, with integrated fecal microbiota transplantation (FMT) experiments to establish causal relationships between GAE-modulated gut microbiota and metabolic improvements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GAE intervention significantly ameliorated HFD-induced metabolic disorders, as evidenced by reduced oxidative stress, enhanced glucose tolerance, suppressed visceral adiposity, and attenuated chronic low-grade inflammation. Mechanistically, GAE preserved intestinal barrier integrity through upregulation of tight junction protein expression. Multi-omics integration of 16S rRNA gene sequencing and untargeted metabolomics revealed that GAE substantially rectified gut microbiota dysbiosis and lipid metabolic disturbances, mediated by specific bioactive metabolites\u2014including lysophosphatidylcholine 22:6 and N-oleoyl glycine\u2014and enrichment of beneficial bacterial genera (\n                      <jats:italic>Phascolarctobacterium<\/jats:italic>\n                      and\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      ). Critically, FMT experiments demonstrated that the gut microbiota remodeled by GAE administration was sufficient to transfer obesity-alleviating phenotypes to recipient mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, these findings establish that GAE exerts multi-target anti-obesity effects through modulation of the \u201cmicrobiota\u2013gut\u2013metabolism\u201d axis, providing compelling preclinical evidence supporting the development of GAE as a functional food ingredient for weight management applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1779459","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:46:15Z","timestamp":1773384375000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Gut 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