{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:10:22Z","timestamp":1773195022531,"version":"3.50.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62176268"],"award-info":[{"award-number":["62176268"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2025-NHLHCRF-JBGS-A-WZ-01"],"award-info":[{"award-number":["2025-NHLHCRF-JBGS-A-WZ-01"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of papillary thyroid carcinoma (PTC) is rising worldwide. Despite its excellent prognosis, many PTC patients experience impaired Health-Related quality of life (HRQoL). Vitamin D exerts pleiotropic effects on musculoskeletal, immune, and psychological health, but its impact on HRQoL in PTC patients remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study consecutively recruited patients with PTC from January 2024 to August 2025. Baseline serum 25-hydroxyvitamin D concentrations were measured before treatment. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and The Thyroid Cancer-Specific Quality of Life Questionnaire (THYCA-QoL) were applied to assess HRQoL. Associations between serum 25-hydroxyvitamin D and HRQoL domains were examined using rank-transformed general linear models, spearman correlation, multivariable linear regression and binary logistic regression. A nomogram was developed to predict the probability of weight gain in HRQoL domains and evaluated using Harrell\u2019s C-index and bootstrap calibration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 600 patients, 27.8% had vitamin D deficiency, 69.5% had insufficiency, and 2.7% had sufficiency. Patients with sufficient vitamin D had better physical functioning and lower social functioning scores than those with deficiency or insufficiency (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.002). Vitamin D was positively correlated with multiple functioning domains and negatively correlated with specific symptoms (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). In linear and logistic regression, higher vitamin D levels were independently associated with better physical and role functioning and fewer symptom burdens, and reduced the odds of impaired physical functioning (OR\u202f=\u202f0.986,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.016) and neuromuscular and weight gain symptoms (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The nomogram showed fair discrimination (C-index 0.628) and good calibration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Suboptimal vitamin D status was common among patients with PTC. Higher vitamin D levels were associated with better physical and role functioning and fewer neuromuscular, psychological, and weight gain symptoms. Assessment of vitamin D status may be considered as part of supportive care when clinically indicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1782902","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:30:32Z","timestamp":1773120632000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum 25-hydroxyvitamin D and health-related quality of life in patients with papillary thyroid carcinoma: a prospective cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenlong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiliang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjia","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-an","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e208759","DOI":"10.1001\/jamanetworkopen.2020.8759","article-title":"Global burden of thyroid cancer from 1990 to 2017","volume":"3","author":"Deng","year":"2020","journal-title":"JAMA Netw Open"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s12020-020-02207-6","article-title":"Thyroid cancer: incidence and mortality trends in China, 2005\u20132015","volume":"68","author":"Wang","year":"2020","journal-title":"Endocrine"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1007\/s12325-020-01391-1","article-title":"Papillary thyroid cancer\u2014aggressive variants and impact on management: a narrative review","volume":"37","author":"Coca-Pelaz","year":"2020","journal-title":"Adv Ther"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00268-018-4479-z","article-title":"Overall survival of papillary thyroid carcinoma patients: a single-institution long-term follow-up of 5,897 patients","volume":"42","author":"Ito","year":"2018","journal-title":"World J Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/j.1365-2265.2011.04114.x","article-title":"Health-related quality of life among thyroid cancer survivors: a systematic review","volume":"75","author":"Husson","year":"2011","journal-title":"Clin Endocrinol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s12020-021-02786-y","article-title":"Distress, anxiety, depression and unmet needs in thyroid cancer survivors: a longitudinal study","volume":"74","author":"Dionisi-Vici","year":"2021","journal-title":"Endocrine"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e210506","DOI":"10.1530\/ec-21-0506","article-title":"Fatigue and quality of life among thyroid cancer survivors without persistent or recurrent disease","volume":"11","author":"Maki","year":"2022","journal-title":"Endocr Connect"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e8070","DOI":"10.1097\/MD.0000000000008070","article-title":"Health-related quality-of-life assessment in surgical patients with papillary thyroid carcinoma","volume":"96","author":"Gou","year":"2017","journal-title":"Medicine"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1007\/s11136-019-02214-9","article-title":"A systematic review of quality of life research in medicine and health sciences","volume":"28","author":"Haraldstad","year":"2019","journal-title":"Qual Life Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/ki.2010.17","article-title":"Vitamin D: a pleiotropic hormone","volume":"78","author":"Verstuyf","year":"2010","journal-title":"Kidney Int"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"898125","DOI":"10.5402\/2013\/898125","article-title":"The pleiotropic effect of vitamin D","volume":"2013","author":"Lai","year":"2013","journal-title":"ISRN Nephrol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1070808","DOI":"10.3389\/fnut.2023.1070808","article-title":"Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: a pooled analysis of 7.9 million participants","volume":"10","author":"Cui","year":"2023","journal-title":"Front Nutr"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"709","DOI":"10.3390\/biom13040709","article-title":"Vitamin D and autoimmune rheumatic diseases","volume":"13","author":"Athanassiou","year":"2023","journal-title":"Biomolecules"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"8855","DOI":"10.3390\/ijms22168855","article-title":"Vitamin D deficiency, osteoporosis and effect on autoimmune diseases and hematopoiesis: a review","volume":"22","author":"De Martinis","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3390\/nu15020422","article-title":"Serum 25-hydroxyvitamin D and cancer risk: a systematic review of Mendelian randomization studies","volume":"15","author":"Lawler","year":"2023","journal-title":"Nutrients"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1186\/s12885-022-09962-x","article-title":"Serum 25-hydroxyvitamin D and cancer-related fatigue: associations and effects on depression, anxiety, functional capacity and health-related quality of life in breast cancer survivors during adjuvant endocrine therapy","volume":"22","author":"Cust\u00f3dio","year":"2022","journal-title":"BMC Cancer"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1200\/jco.2013.54.5947","article-title":"Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer","volume":"32","author":"Zgaga","year":"2014","journal-title":"J Clin Oncol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.3390\/cancers13143516","article-title":"The role of vitamin D as a prognostic marker in papillary thyroid cancer","volume":"13","author":"Bains","year":"2021","journal-title":"Cancers"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.3390\/nu14132593","article-title":"The controversial role of vitamin D in thyroid cancer prevention","volume":"14","author":"Palanca","year":"2022","journal-title":"Nutrients"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jclinepi.2015.08.007","article-title":"Replication and validation of higher order models demonstrated that a summary score for the EORTC QLQ-C30 is robust","volume":"69","author":"Giesinger","year":"2016","journal-title":"J Clin Epidemiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3109\/0284186X.2012.718445","article-title":"Development of a disease-specific health-related quality of life questionnaire (THYCA-QoL) for thyroid cancer survivors","volume":"52","author":"Husson","year":"2013","journal-title":"Acta Oncol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1089\/thy.2025.0149","article-title":"Thyroid cancer survivors experience persistent symptoms and health-related quality-of-life deficits 12 months following surgery","volume":"35","author":"Neill","year":"2025","journal-title":"Thyroid"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.3390\/nu12051248","article-title":"Vitamin D\u2019s effect on immune function","volume":"12","author":"Martens","year":"2020","journal-title":"Nutrients"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"987203","DOI":"10.3389\/fpsyg.2022.987203","article-title":"Impact of vitamin D on cognitive functions in healthy individuals: a systematic review in randomized controlled clinical trials","volume":"13","author":"da Silva","year":"2022","journal-title":"Front Psychol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.maturitas.2011.12.005","article-title":"Vitamin D intake and mental health-related quality of life in older women: the Iowa women's health study","volume":"71","author":"Motsinger","year":"2012","journal-title":"Maturitas"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/aps.2015.55","article-title":"Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study","volume":"36","author":"Gao","year":"2015","journal-title":"Acta Pharmacol Sin"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1451037","DOI":"10.3389\/fnut.2024.1451037","article-title":"The effects of vitamin D levels on physical, mental health, and sleep quality in adults: a comprehensive investigation","volume":"11","author":"Singh","year":"2024","journal-title":"Front Nutr"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e129901","DOI":"10.1371\/journal.pone.0129901","article-title":"The prevalence of vitamin D deficiency among cancer survivors in a nationwide survey of the Korean population","volume":"10","author":"Oh","year":"2015","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3892\/etm.2011.205","article-title":"Prevalence of serum vitamin D deficiency and insufficiency in cancer: review of the epidemiological literature","volume":"2","author":"Gupta","year":"2011","journal-title":"Exp Ther Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1017\/S1368980019004403","article-title":"Does vitamin D status predict weight gain or increase in waist circumference? Results from the longitudinal health 2000\/2011 survey","volume":"23","author":"Jaaskelainen","year":"2020","journal-title":"Public Health Nutr"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1016\/j.injury.2020.06.023","article-title":"Pleiotropic actions of vitamin D in composite musculoskeletal trauma","volume":"51","author":"Valerio","year":"2020","journal-title":"Injury"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"4377","DOI":"10.3390\/nu15204377","article-title":"The role of vitamin D in skeletal muscle repair and regeneration in animal models and humans: a systematic review","volume":"15","author":"Agoncillo","year":"2023","journal-title":"Nutrients"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1210\/er.2012-1012","article-title":"The roles of vitamin D in skeletal muscle: form, function, and metabolism","volume":"34","author":"Girgis","year":"2012","journal-title":"Endocr Rev"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"13824","DOI":"10.18632\/aging.103510","article-title":"Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt\/\u03b2-catenin signaling","volume":"12","author":"G\u00f3mez-Oliva","year":"2020","journal-title":"Aging"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"7809","DOI":"10.3390\/ijms25147809","article-title":"Vitamin D in central nervous system: implications for neurological disorders","volume":"25","author":"Sailike","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"130","DOI":"10.12997\/jla.2021.10.2.130","article-title":"The role of vitamin D in adipose tissue biology: adipocyte differentiation, energy metabolism, and inflammation","volume":"10","author":"Park","year":"2021","journal-title":"J Lipid Atheroscler"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3389\/fphys.2014.00228","article-title":"Vitamin D and adipose tissue\u2014more than storage","volume":"5","author":"Mutt","year":"2014","journal-title":"Front Physiol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e230394","DOI":"10.1530\/EC-23-0394","article-title":"Association of vitamin D levels with anthropometric and adiposity indicators across all age groups: a systematic review of epidemiologic studies","volume":"13","author":"Abiri","year":"2024","journal-title":"Endocr Connect"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/ejcn.2016.245","article-title":"Vitamin D and serum leptin: a systematic review and meta-analysis of observational studies and randomized controlled trials","volume":"71","author":"Hajimohammadi","year":"2016","journal-title":"Eur J Clin Nutr"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/s0899-9007(96)90702-9","article-title":"Anorexia during acute and chronic disease","volume":"12","author":"Plata-Salam\u00e1n","year":"1996","journal-title":"Nutrition"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"6608","DOI":"10.3390\/curroncol31110488","article-title":"Depression, anxiety, and pain predict quality of life in patients with differentiated thyroid cancer postradiotherapy ablation in Taiwan: a 48-week follow-up study","volume":"31","author":"Hsieh","year":"2024","journal-title":"Curr Oncol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"348","DOI":"10.25122\/jml-2022-0204","article-title":"The \u201cnot so good\u201d thyroid cancer: a scoping review on risk factors associated with anxiety, depression and quality of life","volume":"16","author":"Alexander","year":"2023","journal-title":"J Med Life"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.4158\/ep-2020-0201","article-title":"Quality of life in patients with low-risk papillary thyroid microcarcinoma: active surveillance versus immediate surgery","volume":"26","author":"Nakamura","year":"2020","journal-title":"Endocr Pract"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1782902\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:30:33Z","timestamp":1773120633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1782902\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":44,"alternative-id":["10.3389\/fnut.2026.1782902"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1782902","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"article-number":"1782902"}}