{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:58:02Z","timestamp":1774605482331,"version":"3.50.1"},"reference-count":181,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Inflammation and oxidative stress are the key pathogenic mechanisms for the occurrence and development of liver fibrosis. After liver cell damage, excessive reactive oxygen species (ROS) are released, which is a key trigger for the activation of hepatic stellate cells (HSCs). Once activated, HSCs transform into myofibroblasts, leading to excessive extracellular matrix (ECM) deposition and promoting the formation of liver fibrosis. The above processes interact with each other, mutually amplifying and forming a vicious cycle, jointly accelerating the development process of liver fibrosis. The commonly used antioxidants in clinical practice, such as SOD, CAT, and anthocyanins, play a significant role in clinical antioxidant therapy. Vitamins, as common and natural antioxidants, have the characteristic of being both food and medicine, and are relatively safe. Compared with the commonly used antioxidants in clinical settings, vitamins have higher bioavailability, lower adverse reactions and side effects, are widely available, and are easy to obtain. Patients with liver fibrosis often suffer from multiple vitamin deficiencies due to reduced intake, absorption disorders, and increased consumption. This may further accelerate the disease progression. However, the anti-inflammatory and antioxidant effects of vitamins in liver fibrosis and their underlying mechanisms have not been fully elucidated. Moreover, systematic studies on various vitamins are still relatively scarce. Based on the above background, this article systematically elaborates on the research progress of various vitamins in the prevention and treatment of liver fibrosis through their antioxidant and anti-inflammatory mechanisms, with a focus on correcting the deficiency state. The aim is to provide a theoretical basis for precise nutritional intervention for patients with liver fibrosis due to vitamin deficiency.<\/jats:p>","DOI":"10.3389\/fnut.2026.1783979","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:16:05Z","timestamp":1774602965000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The therapeutic potential of vitamins as nutrients in food for anti-inflammatory and anti-oxidative stress in liver fibrosis diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Wanze","family":"Feng","sequence":"first","affiliation":[{"name":"College of Pharmacy, Baotou Medical College","place":["Baotou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Baotou Medical College","place":["Baotou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengxia","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Baotou Medical College","place":["Baotou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlei","family":"Hua","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[{"name":"Central Laboratory, Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine","place":["Hohhot, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhui","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Baotou Medical College","place":["Baotou, China"]},{"name":"Central Laboratory, Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine","place":["Hohhot, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.3390\/cancers13092270","article-title":"Molecular crosstalk between the hepatitis C virus and the extracellular matrix in liver fibrogenesis and early carcinogenesis","volume":"13","author":"Reungoat","year":"2021","journal-title":"Cancers."},{"key":"B2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1002\/imt2.61","article-title":"Targeting keystone species helps restore the dysbiosis of butyrate-producing bacteria in nonalcoholic fatty liver disease","volume":"1","author":"Wu","year":"2022","journal-title":"Imeta"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1002\/imt2.61","article-title":"Targeting keystone species helps restore the dysbiosis of butyrate-producing bacteria in nonalcoholic fatty liver disease","volume":"1","author":"Wu","year":"2022","journal-title":"Imeta."},{"key":"B5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12944-017-0575-6","article-title":"17\u03b2-estradiol lowers triglycerides in adipocytes via estrogen receptor \u03b1 and it may be attenuated by inflammation","volume":"16","author":"Luo","year":"2017","journal-title":"Lipids Health Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.1002\/ptr.8193","article-title":"Plant-derived flavonoids are a potential source of drugs for the treatment of liver fibrosis","volume":"38","author":"Zhao","year":"2024","journal-title":"Phytother Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/nu13010041","article-title":"Creatine alleviates doxorubicin-induced liver damage by inhibiting liver fibrosis, inflammation, oxidative stress, and cellular senescence","volume":"13","author":"Aljobaily","year":"2020","journal-title":"Nutrients."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e2310443","DOI":"10.1002\/adma.202310443","article-title":"Inflammation-responsive cell membrane-camouflaged nanoparticles against liver fibrosis via regulating endoplasmic reticulum stress and oxidative stress","volume":"36","author":"Bai","year":"2024","journal-title":"Adv Mater."},{"key":"B9","doi-asserted-by":"publisher","first-page":"100383","DOI":"10.1016\/j.phanu.2024.100383","article-title":"Structural, functional, nutritional and clinical aspects of vitamin A: a review","volume":"27","author":"Menezes","year":"2024","journal-title":"PharmaNutrition."},{"key":"B10","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/nyas.12297","article-title":"Bioavailability of iron, zinc, folic acid, and vitamin A from fortified maize","volume":"1312","author":"Moretti","year":"2014","journal-title":"Ann N Y Acad Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.3390\/antiox9121292","article-title":"Oxidative stress and antioxidant treatments in cardiovascular diseases","volume":"9","author":"Wang","year":"2020","journal-title":"Antioxidants."},{"key":"B12","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3390\/antiox13030281","article-title":"Redox homeostasis and antioxidant strategies in the pathophysiology","volume":"13","author":"Remigante","year":"2024","journal-title":"Antioxidants."},{"key":"B13","doi-asserted-by":"publisher","first-page":"727861","DOI":"10.3389\/fimmu.2021.727861","article-title":"Monocyte chemotactic protein-induced protein 1 (MCPIP-1): a key player of host defense and immune regulation","volume":"12","author":"Jin","year":"2021","journal-title":"Front Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"103896","DOI":"10.1016\/j.autrev.2025.103896","article-title":"Specialized pro-resolving mediators and autoimmunity: recent insights and future perspectives","volume":"24","author":"Vomero","year":"2025","journal-title":"Autoimmun Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"153712","DOI":"10.1016\/j.phymed.2021.153712","article-title":"Cascade of immune mechanism and consequences of inflammatory disorders","volume":"91","author":"Megha","year":"2021","journal-title":"Phytomedicine."},{"key":"B16","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/antiox13070823","article-title":"OxInflammatory responses in the wound healing process: a systematic review","volume":"13","author":"Lopes","year":"2024","journal-title":"Antioxidants."},{"key":"B17","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/antiox14060735","article-title":"Oxidative stress and inflammation: drivers of tumorigenesis and therapeutic opportunities","volume":"14","author":"Wang","year":"2025","journal-title":"Antioxidants."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1042\/CS20220380","article-title":"Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease","volume":"136","author":"Calder","year":"2022","journal-title":"Clin Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"154890","DOI":"10.1016\/j.metabol.2021.154890","article-title":"Kidney disease in diabetes: from mechanisms to clinical presentation and treatment strategies","volume":"124","author":"Ricciardi","year":"2021","journal-title":"Metabolism."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.3390\/antiox12071318","article-title":"Adherence to mediterranean diet: any association with NAFLD?","volume":"12","author":"Barrea","year":"2023","journal-title":"Antioxidants."},{"key":"B21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/antiox12010009","article-title":"Mitochondrial Peroxiredoxin III protects against non-alcoholic fatty liver disease caused by a methionine-choline deficient diet","volume":"12","author":"Park","year":"2022","journal-title":"Antioxidants."},{"key":"B22","doi-asserted-by":"publisher","first-page":"870239","DOI":"10.3389\/fimmu.2022.870239","article-title":"Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death","volume":"13","author":"Tang","year":"2022","journal-title":"Front Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3390\/antiox12040971","article-title":"Low-dose acetylsalicylic acid and mitochondria-targeted antioxidant mitoquinone attenuate non-alcoholic steatohepatitis in mice","volume":"12","author":"Turkseven","year":"2023","journal-title":"Antioxidants."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.3390\/antiox9111042","article-title":"Comparative effects of pterostilbene and its parent compound resveratrol on oxidative stress and inflammation in steatohepatitis induced by high-fat high-fructose feeding","volume":"9","author":"G\u00f3mez-Zorita","year":"2020","journal-title":"Antioxidants."},{"key":"B25","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s40364-024-00664-z","article-title":"Heat shock proteins (HSPs) in non-alcoholic fatty liver disease (NAFLD): from molecular mechanisms to therapeutic avenues","volume":"12","author":"Nie","year":"2024","journal-title":"Biomark Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11684-019-0729-1","article-title":"Oxidative stress and diabetes: antioxidative strategies","volume":"14","author":"Zhang","year":"2020","journal-title":"Front Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest."},{"key":"B28","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41575-023-00807-x","article-title":"Hepatic inflammatory responses in liver fibrosis","volume":"20","author":"Hammerich","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"8259","DOI":"10.1039\/D1BM01499D","article-title":"Resolving hepatic fibrosis via suppressing oxidative stress and an inflammatory response using a novel hyaluronic acid modified nanocomplex","volume":"9","author":"Ren","year":"2021","journal-title":"Biomater Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/HEP.0000000000001335","article-title":"Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB\/PDIA1","volume":"83","author":"Hazari","year":"2026","journal-title":"Hepatology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.actbio.2023.12.027","article-title":"Collagenase Type I and probucol-loaded nanoparticles penetrate the extracellular matrix to target hepatic stellate cells for hepatic fibrosis therapy","volume":"175","author":"Wang","year":"2024","journal-title":"Acta Biomater."},{"key":"B32","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.freeradbiomed.2020.12.449","article-title":"Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress","volume":"164","author":"Mohammed","year":"2021","journal-title":"Free Radic Biol Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-\u03baB in the liver\u2013linking injury, fibrosis and hepatocellular carcinoma","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.7150\/ijbs.92749","article-title":"Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells","volume":"20","author":"Hao","year":"2024","journal-title":"Int J Biol Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/s41401-020-00545-9","volume":"42","author":"Du","year":"2021","journal-title":"Acta Pharmacol Sin."},{"key":"B36","doi-asserted-by":"publisher","first-page":"6229","DOI":"10.1021\/acsnano.3c09528","article-title":"Cerium-luteolin nanocomplexes in managing inflammation-related diseases by antioxidant and immunoregulation","volume":"18","author":"Gu","year":"2024","journal-title":"ACS Nano."},{"key":"B37","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12944-025-02483-z","article-title":"Fucoidan ameliorates lipid accumulation, oxidative stress, and NF-\u03baB-mediated inflammation by regulating the PI3K\/AKT\/Nrf2 signaling pathway in a free fatty acid-induced NAFLD spheroid model","volume":"24","author":"Chu","year":"2025","journal-title":"Lipids Health Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"140133","DOI":"10.1016\/j.ijbiomac.2025.140133","article-title":"Chlorogenic acid mitigates heat stress-induced oxidative damage in bovine mammary epithelial cells by inhibiting NF-\u03baB-mediated NLRP3 inflammasome activation via upregulating the Nrf2 signaling pathway","volume":"301","author":"Huang","year":"2025","journal-title":"Int J Biol Macromol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"27092","DOI":"10.1007\/s11356-022-24072-8","article-title":"Ammonium induces oxidative stress, endoplasmic reticulum stress, and apoptosis of hepatocytes in the liver cell line of grass carp (Ctenopharyngodon idella)","volume":"30","author":"Hu","year":"2023","journal-title":"Environ Sci Pollut Res Int."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.3390\/antiox12081567","article-title":"Novel therapeutic approaches to liver fibrosis based on targeting oxidative stress","volume":"12","author":"Blas-Garc\u00eda","year":"2023","journal-title":"Antioxidants."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.3390\/antiox11051025","article-title":"Plant- and animal-based antioxidants' structure, efficacy, mechanisms, and applications: a review","volume":"11","author":"Abeyrathne","year":"2022","journal-title":"Antioxidants."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.3390\/antiox11061089","article-title":"Characterization of phytochemicals, nutrients, and antiradical potential in slim amaranth","volume":"11","author":"Sarker","year":"2022","journal-title":"Antioxidants."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3988","DOI":"10.1016\/j.apsb.2023.07.010","article-title":"Oxidative stress, the blood-brain barrier and neurodegenerative diseases: the critical beneficial role of dietary antioxidants","volume":"13","author":"Feng","year":"2023","journal-title":"Acta Pharm Sin B."},{"key":"B44","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1248\/bpb.b16-00933","article-title":"Effects of pre- and post-administration of vitamin A on the growth of refractory cancers in xenograft mice","volume":"40","author":"Li","year":"2017","journal-title":"Biol Pharm Bull."},{"key":"B45","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s13287-024-03852-8","article-title":"The effects of TGF-\u03b2-induced activation and starvation of vitamin A and palmitic acid on human stem cell-derived hepatic stellate cells","volume":"15","author":"Wilhelmsen","year":"2024","journal-title":"Stem Cell Res Ther."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1038\/s44319-024-00158-x","article-title":"Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting","volume":"25","author":"Steinhoff","year":"2024","journal-title":"EMBO Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e70213","DOI":"10.1111\/liv.70213","article-title":"Reduced esterification rather than increased hydrolysis is causative for loss of hepatic retinoids upon CCl4-induced liver injury","volume":"45","author":"Wagner","year":"2025","journal-title":"Liver Int."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.3390\/cells9102244","article-title":"Playing Jekyll and Hyde-the dual role of lipids in fatty liver disease","volume":"9","author":"Molenaar","year":"2020","journal-title":"Cells."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1016\/j.apsb.2025.05.023","article-title":"RXR\u03b1 modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKK\u03b2-AMPK\u03b1 axis","volume":"15","author":"Cai","year":"2025","journal-title":"Acta Pharm Sin B."},{"key":"B50","doi-asserted-by":"publisher","first-page":"8681","DOI":"10.1073\/pnas.82.24.8681","article-title":"Hepatic lipocytes: the principal collagen-producing cells of normal rat liver","volume":"82","author":"Friedman","year":"1985","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B51","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/0014-4827(84)90713-4","article-title":"Newly administered [3H]retinol is transferred from hepatocytes to stellate cells in liver for storage","volume":"150","author":"Blomhoff","year":"1984","journal-title":"Exp Cell Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1182\/blood.2022016832","article-title":"Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis","volume":"141","author":"Men\u00e9ndez-Guti\u00e9rrez","year":"2023","journal-title":"Blood."},{"key":"B53","doi-asserted-by":"publisher","first-page":"691073","DOI":"10.3389\/fimmu.2021.691073","article-title":"Retinoic acid: a new old friend of IL-17A in the immune pathogeny of liver fibrosis","volume":"12","author":"Kartasheva-Ebertz","year":"2021","journal-title":"Front Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2174\/0113816128313964240728155100","article-title":"Retinoic acid improves vascular endothelial dysfunction by inhibiting PI3K\/AKT\/YAP-mediated ferroptosis in diabetes mellitus","volume":"31","author":"Zhang","year":"2025","journal-title":"Curr Pharm Des."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1097\/MEG.0000000000002418","article-title":"Suppressed serological vitamin A in patients with liver cirrhosis is associated with impaired liver function and clinical detoriation","volume":"34","author":"Nagel","year":"2022","journal-title":"Eur J Gastroenterol Hepatol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1111\/cts.12962","article-title":"Altered vitamin A metabolism in human liver slices corresponds to fibrogenesis","volume":"14","author":"Czuba","year":"2021","journal-title":"Clin Transl Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/0260106018777170","volume":"24","year":"2018","journal-title":"Nutr Health."},{"key":"B58","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.3390\/ijms24054642","article-title":"Vitamin D and vitamin D-binding protein in health and disease","volume":"24","author":"Delrue","year":"2023","journal-title":"Int J Mol Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"574967","DOI":"10.3389\/fimmu.2021.574967","article-title":"Immunomodulatory function of vitamin D and its role in autoimmune thyroid disease","volume":"12","author":"Zhao","year":"2021","journal-title":"Front Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e060876","DOI":"10.1136\/bmjopen-2022-060876","article-title":"Vitamin D status in the active duty navy military personnel: protocol for a systematic review","volume":"12","author":"Henriques","year":"2022","journal-title":"BMJ Open."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0038-9","article-title":"Exploring vitamin D metabolism and function in cancer","volume":"50","author":"Jeon","year":"2018","journal-title":"Exp Mol Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D metabolism, mechanism of action, and clinical applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"117250","DOI":"10.1016\/j.ejmech.2025.117250","article-title":"Design, synthesis, and anti-liver fibrosis activity of novel non-steroidal vitamin D receptor agonists based on open-ring steroid scaffold","volume":"286","author":"Gao","year":"2025","journal-title":"Eur J Med Chem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"115596","DOI":"10.1016\/j.ejmech.2023.115596","article-title":"Design, synthesis and anti-hepatic fibrosis activity of novel diphenyl vitamin D receptor agonists","volume":"258","author":"Xing","year":"2023","journal-title":"Eur J Med Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"135480","DOI":"10.1016\/j.jhazmat.2024.135480","article-title":"Vitamin D receptor attenuates carbon tetrachloride-induced liver fibrosis via downregulation of YAP","volume":"478","author":"Wang","year":"2024","journal-title":"J Hazard Mater."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1002\/hep.30937","article-title":"Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice","volume":"71","author":"Dong","year":"2020","journal-title":"Hepatology."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e1801377","DOI":"10.1002\/mnfr.201801377","article-title":"Tomatidine reduces palmitate-induced lipid accumulation by activating AMPK via vitamin D receptor-mediated signaling in human HepG2 hepatocytes","volume":"63","author":"Kusu","year":"2019","journal-title":"Mol Nutr Food Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13020-025-01133-x","article-title":"Senkyunolide I suppresses hepatic stellate cell activation and liver fibrosis by reprogramming VDR-dependent fatty acid metabolism","volume":"20","author":"Zhu","year":"2025","journal-title":"Chin Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"100532","DOI":"10.1016\/j.jhepr.2022.100532","article-title":"Novel role of macrophage TXNIP-mediated CYLD-NRF2-OASL1 axis in stress-induced liver inflammation and cell death","volume":"4","author":"Zhan","year":"2022","journal-title":"JHEP Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"4420","DOI":"10.1038\/s41467-025-59724-z","article-title":"Vitamin D supplementation ameliorates ductular reaction, liver inflammation and fibrosis in mice by upregulating TXNIP in ductular cells","volume":"16","author":"Baek","year":"2025","journal-title":"Nat Commun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"101095","DOI":"10.1016\/j.molmet.2020.101095","article-title":"Insulin-sensitizing effects of vitamin D repletion mediated by adipocyte vitamin D receptor: studies in humans and mice","volume":"42","author":"Lontchi-Yimagou","year":"2020","journal-title":"Mol Metab."},{"key":"B72","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s12276-023-01125-7","article-title":"Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level","volume":"56","author":"Kim","year":"2024","journal-title":"Exp Mol Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3390\/antiox13060729","article-title":"Liver cell mitophagy in metabolic dysfunction-associated steatotic liver disease and liver fibrosis","volume":"13","author":"Chen","year":"2024","journal-title":"Antioxidants."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1136\/gut.2010.234666","article-title":"Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats","volume":"60","author":"Abramovitch","year":"2011","journal-title":"Gut."},{"key":"B75","doi-asserted-by":"publisher","first-page":"G112","DOI":"10.1152\/ajpgi.00132.2013","article-title":"Vitamin D inhibits development of liver fibrosis in an animal model but cannot ameliorate established cirrhosis","volume":"308","author":"Abramovitch","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"109450","DOI":"10.1016\/j.jnutbio.2023.109450","article-title":"Vitamin D deficiency exacerbates alcohol-related liver injury via gut barrier disruption and hepatic overload of endotoxin","volume":"122","author":"Shibamoto","year":"2023","journal-title":"J Nutr Biochem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3390\/nu8050278","article-title":"Effects of vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in cirrhotic patients: a randomized controlled trial","volume":"8","author":"Pilz","year":"2016","journal-title":"Nutrients."},{"key":"B78","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.lfs.2017.04.021","article-title":"1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21","volume":"179","author":"Li","year":"2017","journal-title":"Life Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2014.03.035","article-title":"Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy","volume":"72","author":"Jiang","year":"2014","journal-title":"Free Radic Biol Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.3390\/nu16234115","article-title":"The role of vitamin E isoforms and metabolites in cancer prevention: mechanistic insights into sphingolipid metabolism modulation","volume":"16","author":"Jang","year":"2024","journal-title":"Nutrients."},{"key":"B81","doi-asserted-by":"publisher","first-page":"112143","DOI":"10.1016\/j.foodres.2022.112143","article-title":"Oliveira Sartori A, de Souza Silva AP, Matias de Alencar S. Bioaccessibility and uptake\/epithelial transport of vitamin E: discoveries and challenges of in vitro and ex vivo assays","volume":"162","author":"Catelli Rocha Torres","year":"2022","journal-title":"Food Res Int"},{"key":"B82","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1194\/jlr.R032946","article-title":"Mechanisms for the prevention of vitamin E excess","volume":"54","author":"Traber","year":"2013","journal-title":"J Lipid Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"989","DOI":"10.3390\/antiox11050989","article-title":"Vitamin E (alpha-tocopherol) metabolism and nutrition in chronic kidney disease","volume":"11","author":"Galli","year":"2022","journal-title":"Antioxidants."},{"key":"B84","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3390\/antiox6040095","article-title":"Vitamin E Bioavailability: mechanisms of intestinal absorption in the spotlight","volume":"6","author":"Reboul","year":"2017","journal-title":"Antioxidants."},{"key":"B85","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2016.09.017","article-title":"Vitamin E: emerging aspects and new directions","volume":"102","author":"Galli","year":"2017","journal-title":"Free Radic Biol Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/antiox7010010","article-title":"Long-chain metabolites of vitamin E: metabolic activation as a general concept for lipid-soluble vitamins?","volume":"7","author":"Schubert","year":"2018","journal-title":"Antioxidants."},{"key":"B87","doi-asserted-by":"publisher","first-page":"4957","DOI":"10.3748\/wjg.v11.i32.4957","article-title":"Effects of dietary supplementation with vitamin E and selenium on rat hepatic stellate cell apoptosis","volume":"11","author":"Shen","year":"2005","journal-title":"World J Gastroenterol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1743-7075-11-52","article-title":"Pharmacological potential of tocotrienols: a review","volume":"11","author":"Ahsan","year":"2014","journal-title":"Nutr Metab."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.07.030","article-title":"Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc\/TGF-alpha transgenic mouse model of liver cancer","author":"Calvisi","year":"2004","journal-title":"J Hepatol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1046\/j.1365-2036.2001.01083.x","article-title":"Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study","volume":"15","author":"Hasegawa","year":"2001","journal-title":"Aliment Pharmacol Ther."},{"key":"B91","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/biof.1700","article-title":"Alpha-Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis","volume":"47","author":"Demirel-Yalciner","year":"2021","journal-title":"Biofactors."},{"key":"B92","first-page":"155","article-title":"Major components of metabolic parameters and nutritional intakes in different genotypes of adiponectin +276 G>T gene polymorphism in non-diabetes and non-alcoholic Iranian fatty liver patients","volume":"9","author":"Mohseni","year":"2017","journal-title":"Avicenna J Med Biotechnol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1080\/00365520903114912","article-title":"Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice","volume":"44","author":"Nan","year":"2009","journal-title":"Scand J Gastroenterol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s10020-024-00830-x","article-title":"The gut microbiota-bile acid axis in cholestatic liver disease","volume":"30","author":"Sun","year":"2024","journal-title":"Mol Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"120019","DOI":"10.1016\/j.jep.2025.120019","article-title":"Cortex dictamni induces cholestatic liver injury via the bile acid-gut-liver axis mediated by FXR signaling pathway in rats","volume":"351","author":"Xu","year":"2025","journal-title":"J Ethnopharmacol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"114826","DOI":"10.1016\/j.biopha.2023.114826","article-title":"Reshaping the gut microbiome and bile acid composition by Gyejibongnyeong-hwan ameliorates western diet-induced dyslipidemia","volume":"163","author":"Lee","year":"2023","journal-title":"Biomed Pharmacother."},{"key":"B97","doi-asserted-by":"publisher","first-page":"157108","DOI":"10.1016\/j.phymed.2025.157108","article-title":"Alpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis","volume":"146","author":"Chen","year":"2025","journal-title":"Phytomedicine."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1756284820974917","DOI":"10.1177\/1756284820974917","article-title":"The efficacy of vitamin E in reducing non-alcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression","volume":"13","author":"Abdel-Maboud","year":"2020","journal-title":"Therap Adv Gastroenterol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/hep.30368","article-title":"Vitamin E improves transplant-free survival and hepatic decompensation among patients with nonalcoholic steatohepatitis and advanced fibrosis","volume":"71","author":"Vilar-Gomez","year":"2020","journal-title":"Hepatology."},{"key":"B100","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.crfs.2022.01.018","article-title":"Jakobsen J. In vitro bioaccessibility of vitamin K (phylloquinone and menaquinones) in food and supplements assessed by INFOGEST 20 - vit K","volume":"5","author":"Jensen","year":"2022","journal-title":"Curr Res Food Sci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s00223-022-00955-3","article-title":"Role of vitamin K in bone and muscle metabolism","volume":"112","author":"Alonso","year":"2023","journal-title":"calcif tissue Int."},{"key":"B102","doi-asserted-by":"publisher","first-page":"4629383","DOI":"10.1155\/2018\/4629383","article-title":"Vitamin K and bone metabolism: a review of the latest evidence in preclinical studies","volume":"2018","author":"Akbari","year":"2018","journal-title":"Biomed Res Int."},{"key":"B103","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ijpharm.2018.02.031","article-title":"Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding","volume":"541","author":"Hutton","year":"2018","journal-title":"Int J Pharm."},{"key":"B104","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/s41467-023-36446-8","article-title":"A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase","volume":"14","author":"Jin","year":"2023","journal-title":"Nat Commun."},{"key":"B105","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1055\/s-2002-23205","article-title":"Coagulation disorders in liver disease","volume":"22","author":"Amitrano","year":"2002","journal-title":"Semin Liver Dis."},{"key":"B106","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1053\/j.gastro.2019.03.070","volume":"157","author":"O'Leary","year":"2019","journal-title":"Gastroenterology."},{"key":"B107","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3390\/cells13080681","article-title":"Pregnane X Receptor signaling pathway and vitamin K: molecular mechanisms and clinical relevance in human health","volume":"13","author":"Staudinger","year":"2024","journal-title":"Cells."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.3390\/cells10071571","article-title":"Exogenous vitamins K exert anti-inflammatory effects dissociated from their role as substrates for synthesis of endogenous MK-4 in murine macrophages cell line","volume":"10","author":"Kieronska-Rudek","year":"2021","journal-title":"Cells."},{"key":"B109","doi-asserted-by":"publisher","first-page":"136091","DOI":"10.1016\/j.ijbiomac.2024.136091","article-title":"Vitamin K2 alleviates dextran sulfate sodium-induced colitis via inflammatory responses, gut barrier integrity, and the gut microbiota in mice","volume":"280","author":"Wang","year":"2024","journal-title":"Int J Biol Macromol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.3390\/antiox11112150","article-title":"Vitamin K2 (MK-7) intercepts keap-1\/Nrf-2\/HO-1 pathway and hinders inflammatory\/apoptotic signaling and liver aging in naturally aging rat","volume":"11","author":"El-Sherbiny","year":"2022","journal-title":"Antioxidants."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00821-y","article-title":"Diverse biological functions of vitamin K: from coagulation to ferroptosis","author":"Mishima","year":"2023","journal-title":"Nat Metab."},{"key":"B112","doi-asserted-by":"publisher","first-page":"120357","DOI":"10.1016\/j.jep.2025.120357","article-title":"Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba polysaccharide in alleviating hepatic fibrosis","volume":"353","author":"Fan","year":"2025","journal-title":"J Ethnopharmacol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"114897","DOI":"10.1016\/j.ecoenv.2023.114897","article-title":"Ambient particulate matter exposure plus chronic ethanol ingestion exacerbates hepatic fibrosis by triggering the mitochondrial ROS-ferroptosis signaling pathway in mice","volume":"256","author":"Ding","year":"2023","journal-title":"Ecotoxicol Environ Saf."},{"key":"B114","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1038\/s41598-024-53644-6","article-title":"Vitamin K2 protects mice against non-alcoholic fatty liver disease induced by high-fat diet","volume":"14","author":"Zhao","year":"2024","journal-title":"Sci Rep."},{"key":"B115","doi-asserted-by":"publisher","first-page":"10760296211050923","DOI":"10.1177\/10760296211050923","article-title":"Appropriateness of using vitamin K for the correction of INR elevation secondary to hepatic disease in critically ill patients: an observational study","volume":"27","author":"Al Sulaiman","year":"2021","journal-title":"Clin Appl Thromb Hemost."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1007\/s11096-024-01796-w","article-title":"A retrospective cohort study of coagulation function in patients with liver cirrhosis receiving cefoperazone\/sulbactam with and without vitamin K1 supplementation","volume":"46","author":"Liu","year":"2024","journal-title":"Int J Clin Pharm."},{"key":"B117","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3390\/antiox14050506","article-title":"Vitamin C in cardiovascular disease: from molecular mechanisms to clinical evidence and therapeutic applications","volume":"14","author":"Xu","year":"2025","journal-title":"Antioxidants."},{"key":"B118","doi-asserted-by":"publisher","first-page":"100432","DOI":"10.1016\/j.tcam.2020.100432","article-title":"Vitamin C in health and disease: a companion animal focus","volume":"39","author":"Gordon","year":"2020","journal-title":"top companion Anim Med."},{"key":"B119","doi-asserted-by":"publisher","first-page":"67","DOI":"10.29219\/fnr.v67.10300","article-title":"Vitamin C - a scoping review for nordic nutrition recommendations 2023","volume":"28","author":"Lykkesfeldt","year":"2023","journal-title":"Food Nutr Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"CD000980","DOI":"10.1002\/14651858.CD000980.pub4","article-title":"Vitamin C for preventing and treating the common cold","volume":"2013","author":"Hemil\u00e4","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.3390\/antiox13101194","article-title":"Scavenging of alkylperoxyl radicals by addition to ascorbate: an alternative mechanism to electron transfer","volume":"13","author":"Robert","year":"2024","journal-title":"Antioxidants."},{"key":"B122","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s00424-012-1209-5","article-title":"Hepatic stellate cells\u2013the pericytes in the liver","volume":"465","author":"Hellerbrand","year":"2013","journal-title":"Pflugers Arch."},{"key":"B123","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fphys.2012.00053","article-title":"Differential regulation of TGF-\u03b2\/smad signaling in hepatic stellate cells between acute and chronic liver injuries","volume":"3","author":"Yoshida","year":"2012","journal-title":"Front Physiol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.3892\/ijo.2014.2552","article-title":"TGF-\u03b2\/Smad signaling during hepatic fibro-carcinogenesis (review)","volume":"45","author":"Yoshida","year":"2014","journal-title":"Int J Oncol."},{"key":"B125","first-page":"2820","article-title":"Anticytoproliferative effect of vitamin C on rat hepatic stellate cell","volume":"8","author":"Su","year":"2016","journal-title":"Am J Transl Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3390\/antiox11010069","article-title":"Vitamin C deficiency may delay diet-induced NASH regression in the guinea pig","volume":"11","author":"Skat-R\u00f8rdam","year":"2021","journal-title":"Antioxidants."},{"key":"B127","doi-asserted-by":"publisher","first-page":"110792","DOI":"10.1016\/j.biopha.2020.110792","article-title":"Prophylactic and therapeutic effects of different doses of vitamin C on high-fat-diet-induced non-alcoholic fatty liver disease in mice","volume":"131","author":"Zeng","year":"2020","journal-title":"Biomed Pharmacother."},{"key":"B128","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jare.2021.04.003","article-title":"Integrative omics analysis reveals the protective role of vitamin C on perfluorooctanoic acid-induced hepatoxicity","volume":"35","author":"Li","year":"2021","journal-title":"J Adv Res."},{"key":"B129","doi-asserted-by":"publisher","first-page":"120228","DOI":"10.1016\/j.lfs.2021.120228","article-title":"Vitamin C alleviates alcoholic liver injury by suppressing neutrophil infiltration in senescence marker protein 30-knockout mice irrespective of its antioxidant effects","volume":"297","author":"Baek","year":"2022","journal-title":"Life Sci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2013.10.813","article-title":"Chronic vitamin C insufficiency aggravated thioacetamide-induced liver fibrosis in gulo-knockout mice","volume":"67","author":"Kim","year":"2014","journal-title":"Free Radic Biol Med."},{"key":"B131","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/apt.17359","article-title":"Prevalence and prognostic significance of vitamin C deficiency in patients with acute upper gastrointestinal bleeding: a prospective cohort study","volume":"57","author":"Hui","year":"2023","journal-title":"Aliment Pharmacol Ther."},{"key":"B132","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5152\/tjg.2022.21929","article-title":"Association between serum vitamin C and non-alcoholic fatty liver disease: a cross-sectional study","volume":"34","author":"Guo","year":"2023","journal-title":"Turk J Gastroenterol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.3390\/nu12113380","volume":"12","year":"2020","journal-title":"Nutrients."},{"key":"B134","doi-asserted-by":"publisher","first-page":"89","DOI":"10.7812\/TPP\/21.204","article-title":"B vitamins: functions and uses in medicine","volume":"26","author":"Hanna","year":"2022","journal-title":"Perm J."},{"key":"B135","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.3390\/nu15122734","article-title":"Vitamin B12-multifaceted In Vivo functions and In Vitro applications","volume":"15","author":"Halczuk","year":"2023","journal-title":"Nutrients."},{"key":"B136","doi-asserted-by":"publisher","first-page":"590","DOI":"10.3390\/ijms25010590","article-title":"Vitamin B12 deficiency and the nervous system: beyond metabolic decompensation-comparing biological models and gaining new insights into molecular and cellular mechanisms","volume":"25","author":"Mathew","year":"2024","journal-title":"Int J Mol Sci."},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1177\/17423953231184220","article-title":"Vitamin B12 deficiency in long-term metformin treated type 2 diabetic patients: prevalence and risk factors in a Tunisian population","author":"Yazidi","year":"2024","journal-title":"Chronic Illn."},{"key":"B138","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/jsfa.13661","article-title":"Vitamin B12: prevention of human beings from lethal diseases and its food application","volume":"105","author":"Harikrishnan","year":"2025","journal-title":"J Sci Food Agric."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.jhep.2022.06.033","article-title":"Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation","volume":"77","author":"Tripathi","year":"2022","journal-title":"J Hepatol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13052-022-01396-2","article-title":"Evaluation of thiol disulfide balance in adolescents with vitamin B12 deficiency","volume":"49","author":"Demirtas","year":"2023","journal-title":"Ital J Pediatr."},{"key":"B141","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev-nutr-120524-043056","article-title":"New insights into folate-vitamin B12 interactions","volume":"45","author":"Castillo","year":"2025","journal-title":"Annu Rev Nutr."},{"key":"B142","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.3390\/nu15112597","article-title":"Clinical pathobiochemistry of vitamin B12 deficiency: improving our understanding by exploring novel mechanisms with a focus on diabetic neuropathy","volume":"15","author":"Schleicher","year":"2023","journal-title":"Nutrients."},{"key":"B143","doi-asserted-by":"publisher","first-page":"618","DOI":"10.3390\/metabo14110618","article-title":"Unraveling the association of liver steatosis and fibrosis with vitamin B12: a cross-sectional study","volume":"14","author":"Espina","year":"2024","journal-title":"Metabolites."},{"key":"B144","doi-asserted-by":"publisher","first-page":"CD014217","DOI":"10.1002\/14651858.CD014217","article-title":"Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas","volume":"2","author":"Crider","year":"2022","journal-title":"Cochrane Database Syst Rev."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2021.05.002","article-title":"Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin","volume":"171","author":"Goossens","year":"2021","journal-title":"Free Radic Biol Med."},{"key":"B146","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41586-021-03579-z","article-title":"Structural basis of antifolate recognition and transport by PCFT","volume":"595","author":"Parker","year":"2021","journal-title":"Nature."},{"key":"B147","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41421-022-00508-w","article-title":"Molecular mechanism of substrate recognition by folate transporter SLC19A1","volume":"8","author":"Dang","year":"2022","journal-title":"Cell Discov."},{"key":"B148","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.3390\/nu16183154","article-title":"Supplementation with folic acid or 5-methyltetrahydrofolate and prevention of neural tube defects: an evidence-based narrative review","volume":"16","author":"Samaniego-Vaesken","year":"2024","journal-title":"Nutrients."},{"key":"B149","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.3390\/nu15112525","article-title":"Folate and other B vitamins in brain health and disease","volume":"15","author":"Quadros","year":"2023","journal-title":"Nutrients."},{"key":"B150","doi-asserted-by":"publisher","first-page":"10714","DOI":"10.1080\/10408398.2023.2227888","article-title":"Bacteria from the gut influence the host micronutrient status","volume":"64","author":"Dje Kouadio","year":"2024","journal-title":"Crit Rev Food Sci Nutr."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.3390\/nu16121872","article-title":"Role of folate in liver diseases","volume":"16","author":"Yang","year":"2024","journal-title":"Nutrients."},{"key":"B152","doi-asserted-by":"publisher","first-page":"5025","DOI":"10.1038\/s41598-022-09030-1","article-title":"Serum folate deficiency in HCV related hepatocellular carcinoma","volume":"12","author":"Malaguarnera","year":"2022","journal-title":"Sci Rep."},{"key":"B153","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1684\/ecn.2019.0437","article-title":"Effect of folate supplementation on immunological and autophagy markers in experimental nonalcoholic fatty liver disease","volume":"30","author":"Youssry","year":"2019","journal-title":"Eur Cytokine Netw."},{"key":"B154","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/biof.1154","article-title":"Novel insights on interactions between folate and lipid metabolism","volume":"40","author":"da Silva","year":"2014","journal-title":"Biofactors."},{"key":"B155","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1538\/expanim.20-0075","article-title":"The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats","volume":"70","author":"Akgun","year":"2021","journal-title":"Exp Anim."},{"key":"B156","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/s41418-023-01130-3","article-title":"DNA 5mC and RNA m6A modification successively facilitates the initiation and perpetuation stages of HSC activation in liver fibrosis progression","volume":"30","author":"Feng","year":"2023","journal-title":"Cell Death Differ."},{"key":"B157","doi-asserted-by":"publisher","first-page":"5262","DOI":"10.1039\/D1FO04267J","article-title":"Folic acid intervention changes liver Foxp3 methylation and ameliorates the damage caused by Th17\/Treg imbalance after long-term alcohol exposure","volume":"13","author":"Zhao","year":"2022","journal-title":"Food Funct."},{"key":"B158","doi-asserted-by":"publisher","first-page":"12933","DOI":"10.1038\/s41598-023-39641-1","article-title":"Serum folate associated with nonalcoholic fatty liver disease and advanced hepatic fibrosis","volume":"13","author":"Chen","year":"2023","journal-title":"Sci Rep."},{"key":"B159","doi-asserted-by":"publisher","first-page":"e0599","DOI":"10.1097\/HC9.0000000000000599","article-title":"The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage","volume":"9","author":"Shen","year":"2024","journal-title":"Hepatol Commun."},{"key":"B160","first-page":"436","article-title":"Vitamin B6 and aspartate aminotransferase activity in chronic liver disease","volume":"53","author":"Rossouw","year":"1978","journal-title":"S Afr Med J."},{"key":"B161","first-page":"266","article-title":"Blood vitamin status (B1, B2, B6, folic acid and B12) in patients with alcoholic liver disease","volume":"52","author":"Majumdar","year":"1982","journal-title":"Int J Vitam Nutr Res."},{"key":"B162","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/jgf2.404","article-title":"Association between transient appetite loss and vitamin B1 deficiency in elderly patients with suspected deficiency","volume":"22","author":"Ohta","year":"2020","journal-title":"J Gen Fam Med."},{"key":"B163","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1177\/0891988718819862","article-title":"Blood thiamine level and cognitive function in older hospitalized patients","volume":"32","author":"Pourhassan","year":"2019","journal-title":"J Geriatr Psychiatry Neurol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1515\/cclm-2012-0308","article-title":"B-Vitamin dependent methionine metabolism and alcoholic liver disease","volume":"51","author":"Halsted","year":"2013","journal-title":"Clin Chem Lab Med."},{"key":"B165","doi-asserted-by":"publisher","first-page":"148042","DOI":"10.1016\/j.foodchem.2026.148042","article-title":"Synergistic mechanism of hydrophobic and hydrophilic antioxidants in the interface of tree peony seed oil bilayer emulsion","volume":"505","author":"He","year":"2026","journal-title":"Food Chem."},{"key":"B166","doi-asserted-by":"publisher","first-page":"12172","DOI":"10.1021\/acs.jafc.2c03674","article-title":"Reactivity of vitamin E as an antioxidant in red meat and the stomach medium","volume":"70","author":"Rabkin","year":"2022","journal-title":"J Agric Food Chem."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1660240","DOI":"10.3389\/fnut.2025.1660240","article-title":"Possible role of vitamins C and E co-administration in the prevention of testicular ischemia-reperfusion injury following surgical repair of torsion of the testis","volume":"12","author":"Ogunleye","year":"2025","journal-title":"Front Nutr."},{"key":"B168","first-page":"5951","article-title":"Calcitriol induces estrogen receptor \u03b1 expression through direct transcriptional regulation and epigenetic modifications in estrogen receptor-negative breast cancer cells","volume":"11","author":"Santos-Mart\u00ednez","year":"2021","journal-title":"Am J Cancer Res."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.3390\/cells13221878","article-title":"Synergistic activation of VDR-RXR heterodimers by vitamin D and rexinoids in human kidney and brain cells","volume":"13","author":"Doost","year":"2024","journal-title":"Cells."},{"key":"B170","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s12943-025-02362-2","article-title":"Nuclear receptors as novel regulators that modulate cancer radiosensitivity and normal tissue radiotoxicity","volume":"24","author":"Meng","year":"2025","journal-title":"Mol Cancer."},{"key":"B171","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.ccell.2016.09.004","article-title":"p62\/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer","volume":"30","author":"Duran","year":"2016","journal-title":"Cancer Cell."},{"key":"B172","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.cell.2013.03.028","article-title":"A vitamin D receptor\/SMAD genomic circuit gates hepatic fibrotic response","volume":"153","author":"Ding","year":"2013","journal-title":"Cell."},{"key":"B173","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jare.2024.03.004","article-title":"Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: a review","volume":"68","author":"Li","year":"2025","journal-title":"J Adv Res."},{"key":"B174","doi-asserted-by":"publisher","first-page":"6365","DOI":"10.1038\/s41467-023-42037-4","article-title":"Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo","volume":"14","author":"Mendoza","year":"2023","journal-title":"Nat Commun."},{"key":"B175","doi-asserted-by":"publisher","first-page":"e2302531120","DOI":"10.1073\/pnas.2302531120","article-title":"Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy","volume":"120","author":"Watkins","year":"2023","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1038\/s42255-021-00465-w","article-title":"Methionine synthase supports tumour tetrahydrofolate pools","volume":"3","author":"Ghergurovich","year":"2021","journal-title":"Nat Metab."},{"key":"B177","doi-asserted-by":"publisher","first-page":"e0124","DOI":"10.1097\/HC9.0000000000000124","article-title":"Low vitamin A levels are associated with liver-related mortality: a nationally representative cohort study","volume":"7","author":"Song","year":"2023","journal-title":"Hepatol Commun."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.3390\/cells13191631","article-title":"The interplay between liver and adipose tissue in the onset of liver diseases: exploring the role of vitamin deficiency","volume":"13","author":"Tattoli","year":"2024","journal-title":"Cells."},{"key":"B179","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1039\/D2FO02765H","article-title":"Serum fat-soluble vitamins and the menstrual cycle in women of childbearing age","volume":"14","author":"Zhang","year":"2023","journal-title":"Food Funct."},{"key":"B180","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.tem.2021.08.006","article-title":"Vitamin D toxicity related to its physiological and unphysiological supply","volume":"32","author":"Fraser","year":"2021","journal-title":"Trends Endocrinol Metab."},{"key":"B181","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1053\/j.ajkd.2023.09.005","article-title":"Vitamin supplement use in patients with CKD: worth the pill burden?","volume":"83","author":"Wang","year":"2024","journal-title":"Am J Kidney Dis."}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1783979\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:16:08Z","timestamp":1774602968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1783979\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":181,"alternative-id":["10.3389\/fnut.2026.1783979"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1783979","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"article-number":"1783979"}}